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The existence of complex (multiple-step) genetic adaptations that are "irreducible" (i.e., all partial combinations are less fit than the original genotype) is one of the longest standing problems in evolutionary biology. In standard…

Populations and Evolution · Quantitative Biology 2014-10-17 Meredith V. Trotter , Daniel B. Weissman , Grant I. Peterson , Kayla M. Peck , Joanna Masel

The question of what determines genetic diversity both between and within species has long remained unsolved by the modern evolutionary theory (MET). However, it has not deterred researchers from producing interpretations of genetic…

Populations and Evolution · Quantitative Biology 2019-04-04 Shi Huang

The dynamics of adaptation is difficult to predict because it is highly stochastic even in large populations. The uncertainty emerges from number fluctuations, called genetic drift, arising in the small number of particularly fit…

Populations and Evolution · Quantitative Biology 2015-06-30 Oskar Hallatschek , Lukas Geyrhofer

To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare. But if…

Populations and Evolution · Quantitative Biology 2014-03-25 Richard A. Neher

Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…

Populations and Evolution · Quantitative Biology 2018-04-23 Richard A. Neher , Aleksandra M. Walczak

The selection pressures that have shaped the evolution of complex traits in humans remain largely unknown, and in some contexts highly contentious, perhaps above all where they concern mean trait differences among groups. To date, the…

Populations and Evolution · Quantitative Biology 2020-10-08 Arbel Harpak , Molly Przeworski

Both evolution and ecology have long been concerned with the impact of variable environmental conditions on observed levels of genetic diversity within and between species. We model the evolution of a quantitative trait under selection that…

Populations and Evolution · Quantitative Biology 2014-11-17 Hannes Svardal , Claus Rueffler , Joachim Hermisson

Cryptic genetic sequences have attenuated effects on phenotypes. In the classic view, relaxed selection allows cryptic genetic diversity to build up across individuals in a population, providing alleles that may later contribute to…

Populations and Evolution · Quantitative Biology 2013-05-23 Etienne Rajon , Joanna Masel

It has been hypothesized that one of the main reasons evolution has been able to produce such impressive adaptations is because it has improved its own ability to evolve -- "the evolution of evolvability". Rupert Riedl, for example, an…

Populations and Evolution · Quantitative Biology 2016-12-20 Loizos Kounios , Jeff Clune , Kostas Kouvaris , Günter P. Wagner , Mihaela Pavlicev , Daniel M. Weinreich , Richard A. Watson

We present a model for evolving population which maintains genetic polymorphism. By introducing random mutation in the model population at a constant rate, we observe that the population does not become extinct but survives, keeping…

Soft Condensed Matter · Physics 2009-10-31 H. Y. Lee , D. Kim , M. Y. Choi

One of the most intriguing questions in evolution is how organisms exhibit suitable phenotypic variation to rapidly adapt in novel selective environments which is crucial for evolvability. Recent work showed that when selective environments…

Populations and Evolution · Quantitative Biology 2015-08-28 Kostas Kouvaris , Jeff Clune , Louis Kounios , Markus Brede , Richard A. Watson

If two species exhibit different nonlinear responses to a single shared resource, and if each species modifies the resource dynamics such that this favors its competitor, they may stably coexist. This coexistence mechanism, known as…

Populations and Evolution · Quantitative Biology 2015-06-16 Florian Hartig , Tamara Münkemüller , Karin Johst , Ulf Dieckmann

In classical evolutionary theory, genetic variation provides the source of heritable phenotypic variation on which natural selection acts. Against this classical view, several theories have emphasized that developmental variability and…

Populations and Evolution · Quantitative Biology 2011-11-08 Steven A. Frank

The universal genetic code presents a fundamental paradox in molecular biology. Recent advances in synthetic biology have demonstrated that the code is remarkably flexible--organisms can survive with 61 codons instead of 64, natural…

Populations and Evolution · Quantitative Biology 2025-07-03 Marc Bara Iniesta

In apparent contradiction to competition theory, the number of known, co-existing plankton species far exceeds their explicable biodiversity - a discrepancy termed the Paradox of the Plankton. We introduce a new game-theoretic model for…

Populations and Evolution · Quantitative Biology 2020-12-14 Susanne Menden-Deuer , Julie Rowlett

Range expansion and range shifts are crucial population responses to climate change. Genetic consequences are not well understood but are clearly coupled to ecological dynamics that, in turn, are driven by shifting climate conditions. We…

Populations and Evolution · Quantitative Biology 2016-09-29 Jimmy Garnier , Mark Lewis

Positive selection distorts the structure of genealogies and hence alters patterns of genetic variation within a population. Most analyses of these distortions focus on the signatures of hitchhiking due to hard or soft selective sweeps at a…

Populations and Evolution · Quantitative Biology 2012-08-17 Michael M. Desai , Aleksandra M. Walczak , Daniel S. Fisher

Biological organisms have to cope with stochastic variations in both the external environment and the internal population dynamics. Theoretical studies and laboratory experiments suggest that population diversification could be an effective…

Populations and Evolution · Quantitative Biology 2017-09-13 BingKan Xue , Stanislas Leibler

Maintaining genetic diversity as a means to avoid premature convergence is critical in Genetic Programming. Several approaches have been proposed to achieve this, with some focusing on the mating phase from coupling dissimilar solutions to…

Neural and Evolutionary Computing · Computer Science 2023-03-31 José Maria Simões , Nuno Lourenço , Penousal Machado

One of the problems in applying Genetic Algorithm is that there is some situation where the evolutionary process converges too fast to a solution which causes it to be trapped in local optima. To overcome this problem, a proper diversity in…

Neural and Evolutionary Computing · Computer Science 2011-09-02 Chaiwat Jassadapakorn , Prabhas Chongstitvatana
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