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Mineralized collagen microfibrils in human bone provide its mechanical properties (stiffness, elasticity, ductility, energy dissipation and strength). However, detailed 3D finite element models describing the mechanical behaviour of the…

Tissues and Organs · Quantitative Biology 2012-03-01 Ridha Hambli , Abdelwahed Barkaoui

Bone is a multiscale heterogeneous materiel of which principal function is to support the body structure and to resist mechanical loading and fractures. Bone strength does not depend only on the quantity and quality of bone which is…

Tissues and Organs · Quantitative Biology 2011-07-07 Abdelwahed Barkaoui , Awad Bettamer , Ridha Hambli

Complexity and heterogeneity of bone tissue require a multiscale modelling to understand their mechanical behaviour and their remodelling mechanism. Human cortical bone structure consists of six structural scale levels which are the…

Medical Physics · Physics 2011-12-07 Abdelwahed Barkaoui , Ridha Hambli

Collagen is a key structural protein in the human body, which undergoes mineralization during the formation of hard tissues. Earlier studies have described the mechanical behavior of bone at different scales highlighting material features…

Applied Physics · Physics 2021-07-02 Mario Milazzo , Gang Seob Jung , Serena Danti , Markus J. Buehler

The mineralized collagen fibril is the main building block of hard tissues and it directly affects the macroscopic mechanics of biological tissues such as bone. The mechanical behavior of the fibril itself is determined by its structure:…

Tissues and Organs · Quantitative Biology 2024-03-19 Julia Kamml , Claire Acevedo , David Kammer

The complexity and heterogeneity of bone tissue require a multiscale modelling to understand its mechanical behaviour and its remodelling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based…

Medical Physics · Physics 2014-03-13 Abdelwahed Barkaoui , Abdessalem Chamekh , Merzouki Tarek , Ridha Hambli , Mkaddem Ali

A finite element simulation of the mechanical behaviour of woven textile materials at the scale of individual fibers is proposed in this paper. The aim of the simulation is to understand and identify phenomena involved at different scales…

Soft Condensed Matter · Physics 2008-12-18 Damien Durville

Collagen type I is well-known for its outstanding mechanical properties which it inherits from its hierarchical structure. Collagen type I fibrils may be viewed as an heterogeneous material made of protein, macromolecules (such as…

Soft Condensed Matter · Physics 2024-06-27 Maxime Vassaux

The purpose of this study was to report numerical validation of a 3D finite element model of contracting muscle. The model was based on continuum theory for fibre-reinforced composite materials. Here we simulated contractions for an…

Quantitative Methods · Quantitative Biology 2015-04-03 Hadi Rahemi , Nilima Nigam , James M. Wakeling

Finite element meshes for 3D models simulating realistic malignant melanoma (MM) growth, incorporating accurate dielectric properties of the skin, have been developed. Numerical simulations illustrate how 3D finite element meshes can be…

Numerical Analysis · Mathematics 2025-08-12 Eric Lindström , Larisa Beilina

Modeling of cancellous bone has important applications in the detection and treatment of fatigue fractures and diseases like osteoporosis. In this paper, we present a fully coupled multiscale approach considering mechanical, electrical and…

Computational Engineering, Finance, and Science · Computer Science 2021-06-14 Mischa Blaszczyk , Klaus Hackl

The finite element method (FEM) is used to study the influence of porosity and pore shape on the elastic properties of model porous ceramics. The Young's modulus of each model was found to be practically independent of the solid Poisson's…

Materials Science · Physics 2007-05-23 Anthony P. Roberts , Edward J. Garboczi

Purpose: From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit passive and active mechanical properties, potentially coupled to electrical, chemical, and thermal properties. Experimental characterization of some…

Medical Physics · Physics 2024-06-25 Aude Loumeaud , Philippe Pouletaut , Sabine Bensamoun , Daniel George , Simon Chatelin

In order to establish defined biomimetic systems, type I collagen was functionalised with 1,3-Phenylenediacetic acid (Ph) as aromatic, bifunctional segment. Following investigation on molecular organization and macroscopic properties,…

Biological Physics · Physics 2013-02-11 Giuseppe Tronci , Amanda Doyle , Stephen J. Russell , David J. Wood

This paper describes a two-dimensional (2D) finite element simulation for fracture and fatigue behaviours of pure alumina microstructures such as those found at hip prostheses. Finite element models are developed using actual Al2O3…

Medical Physics · Physics 2012-04-03 Kyungmok Kim , Bernard Forest , Jean Géringer

The mechanical properties of collagen fibrils depend on the amount and the distribution of water molecules within the fibrils. Here, we use atomic force microscopy (AFM) to study the effect of hydration on the viscoelastic properties of…

Soft Condensed Matter · Physics 2019-10-03 Manuel R. Uhlig , Robert Magerle

A general approach to simulate the mechanical behavior of textile materials by taking into account all their constitutive elementary fibers and contacts between them is presented in this paper. A finite element code, based on an implicit…

Materials Science · Physics 2009-12-08 Damien Durville

This work presents the development, analysis and numerical simulations of a biophysical model for 3D cell deformation and movement, which couples biochemical reactions and biomechanical forces. We propose a mechanobiochemical model which…

Cell Behavior · Quantitative Biology 2019-03-25 Laura Murphy , Anotida Madzvamuse

The Young's modulus of a two-dimensional truss-like structure is simulated by using the finite element method. A power-law expression is proposed for the effective Young's modulus of the system. The obtained numerical results are compared…

Soft Condensed Matter · Physics 2007-05-23 Enis Tuncer , Michael Wegener

State of the art research and treatment of biological tissues require accurate and efficient methods for describing their mechanical properties. Indeed, micromechanics motivated approaches provide a systematic method for elevating relevant…

Soft Condensed Matter · Physics 2012-05-04 Gal deBotton , Tal Oren
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