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Molecular Dynamics (MD) is a powerful computational microscope for probing protein functions. However, the need for fine-grained integration and the long timescales of biomolecular events make MD computationally expensive. To address this,…

Machine Learning · Computer Science 2026-03-30 Kacper Kapuśniak , Cristian Gabellini , Michael Bronstein , Prudencio Tossou , Francesco Di Giovanni

Probabilistic model checking can provide formal guarantees on the behavior of stochastic models relating to a wide range of quantitative properties, such as runtime, energy consumption or cost. But decision making is typically with respect…

Logic in Computer Science · Computer Science 2024-03-19 Ingy Elsayed-Aly , David Parker , Lu Feng

Stochastic kinetic models (SKMs) are increasingly used to account for the inherent stochasticity exhibited by interacting populations of species in areas such as epidemiology, population ecology and systems biology. Species numbers are…

Computation · Statistics 2023-04-06 Tom E. Lowe , Andrew Golightly , Chris Sherlock

Recently there has been a great attention from the scientific community towards the use of the model-checking technique as a tool for test generation in the simulation field. This paper aims to provide a useful mean to get more insights…

Logic in Computer Science · Computer Science 2011-11-14 Margherita Napoli , Mimmo Parente

The language Timed Concurrent Constraint (tccp) is the extension over time of the Concurrent Constraint Programming (cc) paradigm that allows us to specify concurrent systems where timing is critical, for example reactive systems. Systems…

Logic in Computer Science · Computer Science 2007-05-23 Moreno Falaschi , Alicia Villanueva

This paper presents algorithms for identifying and reducing a dedicated set of controllable transition rates of a state-labelled continuous-time Markov chain model. The purpose of the reduction is to make states to satisfy a given…

Systems and Control · Computer Science 2016-08-03 Bharath Siva Kumar Tati , Markus Siegle

The development of algorithms for unsupervised pattern recognition by nonlinear clustering is a notable problem in data science. Markov clustering (MCL) is a renowned algorithm that simulates stochastic flows on a network of sample…

Machine Learning · Computer Science 2019-12-30 C. Duran , A. Acevedo , S. Ciucci , A. Muscoloni , CV. Cannistraci

The development of coalescent theory paved the way to statistical inference from population genetic data. In the genomic era, however, coalescent models are limited due to the complexity of the underlying ancestral recombination graph. The…

Populations and Evolution · Quantitative Biology 2021-06-30 Julien Y. Dutheil

Variable Length Memory Chains (VLMC), which are generalizations of finite order Markov chains, turn out to be an essential tool to modelize random sequences in many domains, as well as an interesting object in contemporary probability…

Probability · Mathematics 2020-04-20 Peggy Cénac , Brigitte Chauvin , Camille Noûs , Frédéric Paccaut , Nicolas Pouyanne

Markov decision processes (MDPs) are a fundamental model for decision making under uncertainty. They exhibit non-deterministic choice as well as probabilistic uncertainty. Traditionally, verification algorithms assume exact knowledge of the…

Artificial Intelligence · Computer Science 2025-04-18 Tobias Meggendorfer , Maximilian Weininger , Patrick Wienhöft

We introduce the Markov Stochastic Block Model (MSBM): a growth model for community based networks where node attributes are assigned through a Markovian dynamic. We rely on HMMs' literature to design prediction methods that are robust to…

Social and Information Networks · Computer Science 2023-01-09 Quentin Duchemin

Probabilistic Computation Tree Logic (PCTL) is a well-known modal logic which has become a standard for expressing temporal properties of finite-state Markov chains in the context of automated model checking. In this paper, we give a…

Optimization and Control · Mathematics 2012-02-22 Federico Ramponi , Debasish Chatterjee , Sean Summers , John Lygeros

Verifying quantum systems has attracted a lot of interests in the last decades. In this paper, we initialised the model checking of quantum continuous-time Markov chain (QCTMC). As a real-time system, we specify the temporal properties on…

Quantum Physics · Physics 2024-02-27 Ming Xu , Jingyi Mei , Ji Guan , Nengkun Yu

Stochastic models such as Continuous-Time Markov Chains (CTMC) and Stochastic Hybrid Automata (SHA) are powerful formalisms to model and to reason about the dynamics of biological systems, due to their ability to capture the stochasticity…

Logic in Computer Science · Computer Science 2013-09-05 Ezio Bartocci , Luca Bortolussi , Laura Nenzi , Guido Sanguinetti

Statistical Model Checking (SMC) is a trade-off between testing and formal verification. The core idea of the approach is to conduct some simulations of the system and verify if they satisfy some given property. In this paper we show that…

Software Engineering · Computer Science 2011-11-03 Peter Bulychev , Alexandre David , Kim Guldstrand Larsen , Marius Mikučionis , Axel Legay

Higher-order Markov chains are frequently used to model categorical time series. However, a major problem with fitting such models is the exponentially growing number of parameters in the model order. A popular approach to parsimonious…

Methodology · Statistics 2025-07-03 Tuhin Majumder , Soumendra Lahiri , Donald Martin

Infinite population models are important tools for studying population dynamics of evolutionary algorithms. They describe how the distributions of populations change between consecutive generations. In general, infinite population models…

Neural and Evolutionary Computing · Computer Science 2015-09-29 Bo Song , Victor O. K. Li

Deep Markov models (DMM) are generative models that are scalable and expressive generalization of Markov models for representation, learning, and inference problems. However, the fundamental stochastic stability guarantees of such models…

Machine Learning · Computer Science 2021-11-09 Ján Drgoňa , Sayak Mukherjee , Jiaxin Zhang , Frank Liu , Mahantesh Halappanavar

Markov branching systems form a fundamental class of stochastic models that are extensively applied in biology, physics, finance, and other domains. These systems are distinguished by their continuous-time evolution and inherent branching…

Analyses of serially-sampled data often begin with the assumption that the observations represent discrete samples from a latent continuous-time stochastic process. The continuous-time Markov chain (CTMC) is one such generative model whose…

Applications · Statistics 2009-10-12 Asger Hobolth , Eric A. Stone