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We propose a model for time series taking values on a Riemannian manifold and fit it to time series of covariance matrices derived from EEG data for patients suffering from epilepsy. The aim of the study is two-fold: to develop a model with…

Methodology · Statistics 2024-02-13 Tao Ding , Tom M. W. Nye , Yujiang Wang

To define the neural networks responsible of the epileptic seizure, we had to study the electrophysiological signal in a proper way. The early recognition of the seizure build up could also be defined through the time space mapping of the…

Signal Processing · Electrical Eng. & Systems 2019-11-19 Ridha Jarray , Nawel Jmail , Abir Hadriche , Tarek Frikha , Chokri Ben Amar

This work introduces a new approach to the Epileptic Spasms (ESES) detection based on the EEG signals using Vision Transformers (ViT). Classic ESES detection approaches have usually been performed with manual processing or conventional…

Neurons and Cognition · Quantitative Biology 2024-12-18 Wei Gong , Yaru Li

Inferring strength and direction of interactions from electroencephalographic (EEG) recordings is of crucial importance to improve our understanding of dynamical interdependencies underlying various physiologic and pathophysiologic…

Neurons and Cognition · Quantitative Biology 2016-10-07 Klaus Lehnertz , Henning Dickten

Differential operators can detect significant changes in signals. This has been utilized to enhance the contrast of the seizure signatures in depth EEG or ECoG. We have actually taken normalized exponential of absolute value of single or…

Quantitative Methods · Quantitative Biology 2009-11-03 Kaushik Majumdar

This work considers the problem of detecting signals from multiple sequentially observed data streams, where only one stream can be observed at every time instant. The goal is to detect signals as quickly as possible while controlling the…

Methodology · Statistics 2026-04-07 Yiming Xing , Georgios Fellouris

Epilepsy is a disorder characterised by spontaneous, recurrent seizures. Both local and network abnormalities have been associated with epilepsy, and the exact processes generating seizures are thought to be heterogeneous and…

Neurons and Cognition · Quantitative Biology 2019-01-07 Yujiang Wang , Gabrielle Marie Schroeder , Nishant Sinha , Peter Neal Taylor

Epilepsy and psychogenic non-epileptic seizures often present with similar seizure-like manifestations but require fundamentally different management strategies. Misdiagnosis is common and can lead to prolonged diagnostic delays,…

Computation and Language · Computer Science 2026-03-31 Shuang Zhou , Kai Yu , Zaifu Zhan , Huixue Zhou , Min Zeng , Feng Xie , Zhiyi Sha , Rui Zhang

Predicting seizure freedom is essential for tailoring epilepsy treatment. But accurate prediction remains challenging with traditional methods, especially with diverse patient populations. This study developed a deep learning-based graph…

Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied…

Machine Learning · Statistics 2014-07-29 Drausin F. Wulsin , Emily B. Fox , Brian Litt

Epilepsy is one of the most common neurological disorders that can be diagnosed through electroencephalogram (EEG), in which the following epileptic events can be observed: pre-ictal, ictal, post-ictal, and interictal. In this paper, we…

Machine Learning · Computer Science 2021-02-12 Jefferson Tales Oliva , João Luís Garcia Rosa

Recently, the SPIKE-distance has been proposed as a parameter-free and time-scale independent measure of spike train synchrony. This measure is time-resolved since it relies on instantaneous estimates of spike train dissimilarity. However,…

Data Analysis, Statistics and Probability · Physics 2012-12-11 Thomas Kreuz , Daniel Chicharro , Conor Houghton , Ralph G Andrzejak , Florian Mormann

Clinical trials assessing neurological treatment are challenging due to the diversity of brain function, and the difficulty in quantifying it. Traditional treatment studies in epilepsy use seizure frequency as the primary outcome measure,…

Applications · Statistics 2025-12-02 Ian Miller , Ann Hyslop , Colin Decker

Epilepsy significantly impacts global health, affecting about 65 million people worldwide, along with various animal species. The diagnostic processes of epilepsy are often hindered by the transient and unpredictable nature of seizures.…

Signal Processing · Electrical Eng. & Systems 2026-04-21 Z. Wang , S. Li , Dongrui Wu

Epilepsy is the most common, chronic, neurological disease worldwide and is typically accompanied by reoccurring seizures. Neuro implants can be used for effective treatment by suppressing an upcoming seizure upon detection. Due to the…

Signal Processing · Electrical Eng. & Systems 2025-05-12 Julia Werner , Bhavya Kohli , Paul Palomero Bernardo , Christoph Gerum , Oliver Bringmann

We propose a simple method to measure synchronization and time delay patterns between signals. It is based on the relative timings of events in the time series, defined e.g. as local maxima. The degree of synchronization is obtained from…

Chaotic Dynamics · Physics 2007-05-23 R. Quian Quiroga , T. Kreuz , P. Grassberger

Epileptic seizures are characterized by abnormal and excessive neural activity, where cortical network dynamics seem to become unstable. However, most of the time, during seizure-free periods, cortex of epilepsy patients shows perfectly…

Neurons and Cognition · Quantitative Biology 2021-04-06 Annika Hagemann , Jens Wilting , Bita Samimizad , Florian Mormann , Viola Priesemann

Recent statistical and reinforcement learning methods have significantly advanced patient care strategies. However, these approaches face substantial challenges in high-stakes contexts, including missing data, inherent stochasticity, and…

Machine Learning · Computer Science 2024-04-02 Harsh Parikh , Quinn Lanners , Zade Akras , Sahar F. Zafar , M. Brandon Westover , Cynthia Rudin , Alexander Volfovsky

Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually in-variant across seizures in a same…

Neurons and Cognition · Quantitative Biology 2018-05-09 Timothée Proix , Viktor K. Jirsa , Fabrice Bartolomei , Maxime Guye , Wilson Truccolo

Objective: This work presents a new computational framework to assist neurophysiologists in Stereoelectroencephalography (SEEG) analysis, with the goal of improving the definition of the Epileptogenic Zone (EZ) in patients with…

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