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We present an algorithm for phylogenetic reconstruction using quartets that returns the correct topology for $n$ taxa in $O(n \log n)$ time with high probability, in a probabilistic model where a quartet is not consistent with the true…

Populations and Evolution · Quantitative Biology 2010-10-12 Daniel G. Brown , Jakub Truszkowski

We consider the problem of constructing an an optimal-weight tree from the 3*(n choose 4) weighted quartet topologies on n objects, where optimality means that the summed weight of the embedded quartet topologiesis optimal (so it can be the…

Data Structures and Algorithms · Computer Science 2011-11-09 Rudi Cilibrasi , Paul M. B. Vitanyi

We propose a reinforcement-learning algorithm to tackle the challenge of reconstructing phylogenetic trees. The search for the tree that best describes the data is algorithmically challenging, thus all current algorithms for phylogeny…

Populations and Evolution · Quantitative Biology 2023-03-14 Dana Azouri , Oz Granit , Michael Alburquerque , Yishay Mansour , Tal Pupko , Itay Mayrose

A phylogenetic tree is a graphical representation of an evolutionary history of taxa in which the leaves correspond to the taxa and the non-leaves correspond to speciations. One of important problems in phylogenetic analysis is to assemble…

Combinatorics · Mathematics 2022-02-25 Hiroshi Hirai , Yuni Iwamasa

We apply classical quartet techniques to the problem of phylogenetic decisiveness and find a value $k$ such that all collections of at least $k$ quartets are decisive. Moreover, we prove that this bound is optimal and give a lower-bound on…

Quantitative Methods · Quantitative Biology 2015-03-17 Emili Moan , Joseph Rusinko

Among the distance based algorithms in phylogenetic tree reconstruction, the neighbor-joining algorithm has been a widely used and effective method. We propose a new algorithm which counts the number of consistent quartets for cherry…

Populations and Evolution · Quantitative Biology 2023-10-31 Jin-Hwan Cho , Dosang Joe , Young Rock Kim

We introduce new methods for phylogenetic tree quartet construction by using machine learning to optimize the power of phylogenetic invariants. Phylogenetic invariants are polynomials in the joint probabilities which vanish under a model of…

Populations and Evolution · Quantitative Biology 2007-05-23 Nicholas Eriksson , Yuan Yao

Discovering the latent structure from many observed variables is an important yet challenging learning task. Existing approaches for discovering latent structures often require the unknown number of hidden states as an input. In this paper,…

Machine Learning · Computer Science 2012-10-05 Mariya Ishteva , Haesun Park , Le Song

Background: The reconstruction of the phylogenetic tree topology of four taxa is, still nowadays, one of the main challenges in phylogenetics. Its difficulties lie in considering not too restrictive evolutionary models, and correctly…

Populations and Evolution · Quantitative Biology 2014-06-19 Esther Ibáñez , Marta Casanellas

One reason why classical phylogenetic reconstruction methods fail to correctly infer the underlying topology is because they assume oversimplified models. In this paper we propose a topology reconstruction method consistent with the most…

Populations and Evolution · Quantitative Biology 2014-10-28 Jesús Fernández-Sánchez , Marta Casanellas

Quartet Reconstruction, the task of recovering a phylogenetic tree from smaller trees on four species called \textit{quartets}, is a well-studied problem in theoretical computer science with far-reaching connections to statistics, graph…

Data Structures and Algorithms · Computer Science 2026-04-21 Dionysis Arvanitakis , Vaggos Chatziafratis , Yiyuan Luo , Konstantin Makarychev

Given a set of n data objects and their pairwise dissimilarities, the goal of the minimum quartet tree cost (MQTC) problem is to construct an optimal tree from the total number of possible combinations of quartet topologies on n, where…

Discrete Mathematics · Computer Science 2018-07-03 Sergio Consoli , Jan Korst , Gijs Geleijnse , Steffen Pauws

Motivation: Word-based or `alignment-free' methods for phylogeny reconstruction are much faster than traditional approaches, but they are generally less accurate. Most of these methods calculate pairwise distances for a set of input…

Populations and Evolution · Quantitative Biology 2018-05-01 Thomas Dencker , Chris-Andre Leimeister , Michael Gerth , Christoph Bleidorn , Sagi Snir , Burkhard Morgenstern

We analyse a maximum-likelihood approach for combining phylogenetic trees into a larger `supertree'. This is based on a simple exponential model of phylogenetic error, which ensures that ML supertrees have a simple combinatorial description…

Populations and Evolution · Quantitative Biology 2007-08-17 Mike Steel , Allen Rodrigo

Topological phylogenetic trees can be assigned edge weights in several natural ways, highlighting different aspects of the tree. Here the rooted triple and quartet metrizations are introduced, and applied to formulate novel fast methods of…

Populations and Evolution · Quantitative Biology 2019-05-15 John A. Rhodes

Complex systems of polynomial equations have to be set up and solved algebraically in order to obtain analytic solutions for maximum likelihood on phylogenetic trees. This has restricted the types of systems previously resolved to the…

Populations and Evolution · Quantitative Biology 2007-05-23 Benny Chor , Michael D. Hendy , Sagi Snir

Recently there has been renewed interest in phylogenetic inference methods based on phylogenetic invariants, alongside the related Markov invariants. Broadly speaking, both these approaches give rise to polynomial functions of sequence site…

Quantitative Methods · Quantitative Biology 2017-03-31 Jeremy G Sumner , Amelia Taylor , Barbara R Holland , Peter D Jarvis

Quartet trees displayed by larger phylogenetic trees have long been used as inputs for species tree and supertree reconstruction. Computational constraints prevent the use of all displayed quartets in many practical problems due to the…

Populations and Evolution · Quantitative Biology 2016-12-07 Ruth Davidson , MaLyn Lawhorn , Joseph Rusinko , Noah Weber

Applying a method to reconstruct a phylogenetic tree from random data provides a way to detect whether that method has an inherent bias towards certain tree `shapes'. For maximum parsimony, applied to a sequence of random 2-state data, each…

Populations and Evolution · Quantitative Biology 2014-06-03 Mareike Fischer , Michelle Galla , Lina Herbst , Mike Steel

A chief problem in phylogenetics and database theory is the computation of a maximum consistent tree from a set of rooted or unrooted trees. A standard input are triplets, rooted binary trees on three leaves, or quartets, unrooted binary…

Discrete Mathematics · Computer Science 2010-05-31 Leo van Iersel , Matthias Mnich
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