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When a biological system robustly corrects component-level errors, the direct pressure on component performance declines. Components may become less reliable, maintain more genetic variability, or drift neutrally in design, creating the…

Populations and Evolution · Quantitative Biology 2023-12-27 Steven A. Frank

While the deployment of deep learning models on edge devices is increasing, these models often lack robustness when faced with dynamic changes in sensed data. This can be attributed to sensor drift, or variations in the data compared to…

Machine Learning · Computer Science 2024-05-29 Dong Wang , Olga Saukh , Xiaoxi He , Lothar Thiele

For many networks, the connection pattern (often called the topology) can vary in time, depending on the changing state, or mode, of the modules within the network. For example, "airplane mode" is the name for one communicative mode of a…

Dynamical Systems · Mathematics 2015-12-15 David I. Spivak , Joshua Z. Tan

In this work, we perform an exploratory study on synthesizing deep neural networks using biological synaptic strength distributions, and the potential influence of different distributions on modelling performance particularly for the…

Neural and Evolutionary Computing · Computer Science 2017-07-04 A. H. Karimi , M. J. Shafiee , A. Ghodsi , A. Wong

It has been proposed that adaptation in complex systems is optimized at the critical boundary between ordered and disordered dynamical regimes. Here, we review models of evolving dynamical networks that lead to self-organization of network…

Adaptation and Self-Organizing Systems · Physics 2008-11-07 Thimo Rohlf , Stefan Bornholdt

We study a model of spiking neurons, with recurrent connections that result from learning a set of spatio-temporal patterns with a spike-timing dependent plasticity rule and a global inhibition. We investigate the ability of the network to…

Neurons and Cognition · Quantitative Biology 2020-04-22 S. Scarpetta , A. de Candia

A Boolean network (BN) with $n$ components is a discrete dynamical system described by the successive iterations of a function $f:\{0,1\}^n \to \{0,1\}^n$. This model finds applications in biology, where fixed points play a central role.…

Combinatorics · Mathematics 2022-02-10 Florian Bridoux , Amélia Durbec , Kévin Perrot , Adrien Richard

We study the evolution of networks when the creation and decay of links are based on the position of nodes in the network measured by their centrality. We show that the same network dynamics arises under various centrality measures, and…

Physics and Society · Physics 2013-05-29 Michael D. Koenig , Claudio J. Tessone

Boolean networks have been proposed as potentially useful models for genetic control. An important aspect of these networks is the stability of their dynamics in response to small perturbations. Previous approaches to stability have assumed…

Molecular Networks · Quantitative Biology 2015-05-13 Andrew Pomerance , Edward Ott , Michelle Girvan , Wolfgang Losert

We analyze how a star network topology shapes the dynamics of coupled CO\textsubscript{2} lasers with an intracavity electro-optic modulator that exhibit bistability. Such a network supports spreading and stationary activation patterns. In…

Chaotic Dynamics · Physics 2018-11-21 Joniald Shena , Johanne Hizanidis , Nikos E. Kouvaris , Giorgos P. Tsironis

Networks are ubiquitous in biology where they encode connectivity patterns at all scales of organization, from molecular to the biome. However, biological networks are noisy due to the limitations of measurement technology and inherent…

Molecular Networks · Quantitative Biology 2018-08-16 Bo Wang , Armin Pourshafeie , Marinka Zitnik , Junjie Zhu , Carlos D. Bustamante , Serafim Batzoglou , Jure Leskovec

The mechanics of complex soft matter often cannot be understood in the classical physical frame of flexible polymers or rigid rods. The underlying constituents are semiflexible polymers, whose finite bending stiffness ($\kappa$) leads to…

It is a fundamental challenge to understand how the function of a network is related to its structural organization. Adaptive dynamical networks represent a broad class of systems that can change their connectivity over time depending on…

Adaptation and Self-Organizing Systems · Physics 2023-04-13 Rico Berner , Thilo Gross , Christian Kuehn , Jürgen Kurths , Serhiy Yanchuk

The recent discovery of universal principles underlying many complex networks occurring across a wide range of length scales in the biological world has spurred physicists in trying to understand such features using techniques from…

Biological Physics · Physics 2015-05-13 Sitabhra Sinha

We model a system of networking agents that seek to optimize their centrality in the network while keeping their cost, the number of connections they are participating in, low. Unlike other game-theory based models for network evolution,…

Populations and Evolution · Quantitative Biology 2007-05-23 Petter Holme , Gourab Ghoshal

We study the synchronization of coupled dynamical systems on a variety of networks. The dynamics is governed by a local nonlinear map or flow for each node of the network and couplings connecting different nodes via the links of the…

Chaotic Dynamics · Physics 2009-11-13 R. E. Amritkar , Sarika Jalan

Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a…

Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , Curtis G Callan , William Bialek

This paper deals with Networked Control Systems (NCSs) whose shared networks have limited communication capacity and are prone to data losses. We assume that among (N) plants, only (M < N) plants can communicate with their controllers at…

Optimization and Control · Mathematics 2021-11-11 Atreyee Kundu , Daniel E. Quevedo

For years, we have been building models of gene regulatory networks, where recent advances in molecular biology shed some light on new structural and dynamical properties of such highly complex systems. In this work, we propose a novel…

Adaptation and Self-Organizing Systems · Physics 2009-09-30 Christian Darabos , Marco Tomassini , Mario Giacobini