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Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

On the basis of the information theory approach we propose a novel statistical scheme for analyzing the evolution of coupled adsorbate-substrate systems, in which the substrate undergoes the adsorbate-induced transformations. A relation…

Statistical Mechanics · Physics 2009-11-10 E. V. Vakarin , J. P. Badiali

Coupled natural systems are generally modeled at multiple abstraction levels. Both structural scale and behavioral complexity of these models are determinants in the kinds of questions that can be posed and answered. As scale and complexity…

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Worsening global challenges demand solutions grounded in a systems-level understanding of coupled social and environmental dynamics. Existing environmental models encode extensive knowledge of individual systems, yet much of this…

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Nanoscale design of surfaces and interfaces is essential for modern technologies like organic LEDs, batteries, fuel cells, superlubricating surfaces, and heterogeneous catalysis. However, these systems often exhibit complex surface…

Materials Science · Physics 2025-07-08 Lukas Hörmann , Wojciech G. Stark , Reinhard J. Maurer

Computation, mechanics and materials merge in biological systems, which can continually self-optimize through internal adaptivity across length scales, from cytoplasm and biofilms to animal herds. Recent interest in such material-based…

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Quantifying organism-level phenotypes, such as growth dynamics and biomass accumulation, is fundamental to understanding agronomic traits and optimizing crop production. However, quality growing data of plants at scale is difficult to…

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Cellular regulatory dynamics is driven by large and intricate networks of interactions at the molecular scale, whose sheer size obfuscates understanding. In light of limited experimental data, many parameters of such dynamics are unknown,…

Quantitative Methods · Quantitative Biology 2014-04-30 Bryan C. Daniels , Ilya Nemenman

Complex models in physics, biology, economics, and engineering are often sloppy, meaning that the model parameters are not well determined by the model predictions for collective behavior. Many parameter combinations can vary over decades…

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A computational framework integrating optimization algorithms, parallel computing and plant physiology was developed to explore crop ideotype design. The backbone of the framework is a plant physiology model that accurately tracks water use…

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Modeling environmental ecosystems is essential for effective resource management, sustainable development, and understanding complex ecological processes. However, traditional methods frequently struggle with the inherent complexity,…

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Search-Based Software Engineering (SBSE) is a promising paradigm that exploits the computational search to optimize different processes when engineering complex software systems. Self-adaptive system (SAS) is one category of such complex…

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Science mapping (SM), the study of the organization and development of science and technology, is a rapidly developing field within information science. The volume of available data allows this methodology to empirically address such issues…

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Causal structure discovery (CSD) models are making inroads into several domains, including Earth system sciences. Their widespread adaptation is however hampered by the fact that the resulting models often do not take into account the…

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It is known that statistical model selection as well as identification of dynamical equations from available data are both very challenging tasks. Physical systems behave according to their underlying dynamical equations which, in turn, can…

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In contrast to many other engineering fields, the uncertainties in subsurface processes (e.g., fluid flow and contaminant transport in aquifers) and their parameters are notoriously difficult to observe, measure, and characterize. This…

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The surface properties of solid-state materials often dictate their functionality, especially for applications where nanoscale effects become important. The relevant surface(s) and their properties are determined, in large part, by the…

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Modeling environmental ecosystems is essential for effective resource management, sustainable development, and understanding complex ecological processes. However, traditional data-driven methods face challenges in capturing inherently…

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Growing mixtures of annual arable crop species or genotypes is a promising way to improve crop production without increasing agricultural inputs. To design optimal crop mixtures, choices of species, genotypes, sowing proportion, plant…

Breakthroughs in aerodynamic optimization have made it possible to develop efficient modes of transport with lesser exploitation of valuable resources. This makes it crucial for technical professionals such as engineers and scientists to…

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