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According to the chemical reaction network theory, the topology of a certain class of chemical reaction networks, regardless of the kinetic details, sets a limit on the dynamical properties that a particular network can potentially admit;…

Molecular Networks · Quantitative Biology 2014-08-21 Jaewook Joo , Sanjeev Chauhan

Oscillation has an important role in bio-dynamical systems such as circadian rhythms and eukaryotic cell cycle. John Tyson et. al. in Nature Review Mol Cell Biol 2008 examined a limited number of network topologies consisting of three nodes…

Molecular Networks · Quantitative Biology 2011-10-14 Matthew Bailey , Jaewook Joo

Coupling frequently enhances noise-induced coherence and synchronization in interacting nonlinear systems, but it does so separately. In principle collective stochastic coherence and synchronizability are incompatible phenomena, since…

Adaptation and Self-Organizing Systems · Physics 2015-06-17 Pablo Balenzuela , Pau Rué , Stefano Boccaletti , Jordi García-Ojalvo

Deterministic and stochastic Boolean network models are build for the dynamics of negative feedback loops of the p53 pathways. It is shown that the main function of the negative feedback in the p53 pathways is to keep p53 at a low steady…

Molecular Networks · Quantitative Biology 2009-04-16 Hao Ge , Min Qian

Complex network dynamics have been analyzed with models of systems of coupled switches or systems of coupled oscillators. However, many complex systems are composed of components with diverse dynamics whose interactions drive the system's…

Quantitative Methods · Quantitative Biology 2012-01-09 Matthew R. Francis , Elana J. Fertig

The theory of mixed-feedback systems provides an effective framework for the design of robust and tunable oscillations in nonlinear systems characterized by interleaved fast positive and slow negative feedback loops. The goal of this paper…

Dynamical Systems · Mathematics 2024-12-11 Omar Juarez-Alvarez , Alessio Franci

Hybrid oscillator architectures that combine feedback oscillators with self-sustained negative resistance oscillators have emerged as a promising platform for artificial neuron design. In this work, we introduce a modeling and analysis…

Chemical Physics · Physics 2025-08-04 Gonzalo Rivera-Sierra , Roberto Fenollosa , Juan Bisquert

Living organisms must respond to environmental changes. Generally, accurate and rapid responses are provided by simple, unidirectional networks that connect inputs with outputs. Besides accuracy and speed, biological responses should also…

Molecular Networks · Quantitative Biology 2021-09-01 Masayo Inoue , Kunihiko Kaneko

Organisms are equipped with regulatory systems that display a variety of dynamical behaviours ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein…

Molecular Networks · Quantitative Biology 2009-11-13 Simone Pigolotti , Sandeep Krishna , Mogens H. Jensen

For cellular biochemical reaction systems where the numbers of molecules is small, significant noise is associated with chemical reaction events. This molecular noise can give rise to behavior that is very different from the predictions of…

Molecular Networks · Quantitative Biology 2009-11-13 Matthew Scott , Terence Hwa , Brian Ingalls

Collective oscillation of cells in a population has been reported under diverse biological contexts and with vastly different molecular constructs. Could there be common principles similar to those that govern spontaneous oscillation in…

Cell Behavior · Quantitative Biology 2019-07-08 Shou-Wen Wang , Lei-Han Tang

Oscillations arise in many real-world systems and are associated with both functional and dysfunctional states. Whether a network can oscillate can be estimated if we know the strength of interaction between nodes. But in real-world…

Neurons and Cognition · Quantitative Biology 2023-11-16 Jie Zang , Shenquan Liu , Pascal Helson , Arvind Kumar

Natural and artificial networks, from the cerebral cortex to large-scale power grids, face the challenge of converting noisy inputs into robust signals. The input fluctuations often exhibit complex yet statistically reproducible…

Adaptation and Self-Organizing Systems · Physics 2018-11-19 Henrik Ronellenfitsch , Jörn Dunkel , Michael Wilczek

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

Neurons and networks in the cerebral cortex must operate reliably despite multiple sources of noise. To evaluate the impact of both input and output noise, we determine the robustness of single-neuron stimulus selective responses, as well…

Neurons and Cognition · Quantitative Biology 2018-01-24 Ran Rubin , L. F. Abbott , Haim Sompolinsky

Biological rhythms are generated by pacemaker organs, such as the heart pacemaker organ (the sinoatrial node) and the master clock of the circadian rhythms (the suprachiasmatic nucleus), which are composed of a network of autonomously…

Cell Behavior · Quantitative Biology 2016-08-23 Hiroshi Kori , Yoji Kawamura , Naoki Masuda

Large networks of sparsely coupled, excitatory and inhibitory cells occur throughout the brain. A striking feature of these networks is that they are chaotic. How does this chaos manifest in the neural code? Specifically, how variable are…

Neurons and Cognition · Quantitative Biology 2014-02-25 Guillaume Lajoie , Jean-Philippe Thivierge , Eric Shea-Brown

Biological systems rely on robust internal information processing: Survival depends on highly reproducible dynamics of regulatory processes. Biological information processing elements, however, are intrinsically noisy (genetic switches,…

Molecular Networks · Quantitative Biology 2009-11-10 Konstantin Klemm , Stefan Bornholdt

We set up a signal-driven scheme of the chaotic neural network with the coupling constants corresponding to certain information, and investigate the stochastic resonance-like effects under its deterministic dynamics, comparing with the…

Chaotic Dynamics · Physics 2007-05-23 Haruhiko Nishimura , Naofumi Katada , Kazuyuki Aihara

Complex networks are abundant in nature and many share an important structural property: they contain a few nodes that are abnormally highly connected (hubs). Some of these hubs are called influencers because they couple strongly to the…

Adaptation and Self-Organizing Systems · Physics 2024-09-04 Ralf Tönjes , Carlos E. Fiore , Tiago Pereira
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