Related papers: Self-organizing magnetic beads for biomedical appl…
In the field of biomedicine magnetic beads are used for drug delivery and to treat hyperthermia. Here we propose to use self-organized bead structures to isolate circulating tumor cells using lab-on-chip technologies. Typically blood flows…
Micromagnetic beads are widely used in biomedical applications for cell separation, drug delivery, and hypothermia cancer treatment. Here we propose to use self-organized magnetic bead structures which accumulate on fixed magnetic seeding…
We propose to use a compound of magnetic nanoparticles (20-100 nm) embedded in a flexible polymer (Polydimethylsiloxane PDMS) to filter circulating tumor cells (CTCs). The analysis of CTCs is an emerging tool for cancer biology research and…
Molecular adhesion plays a central role in many biological systems, yet existing methods to quantify adhesive strength often struggle to bridge the gap between single-molecule resolution and biologically relevant environments. Here, we…
Controlled transport of surface functionalized magnetic beads in a liquid medium is a central requirement for the handling of captured biomolecular targets in microfluidic lab-on-chip biosensors. Here, the influence of the physiological…
We study the self-assembly of branching-chain networks and crystals in a binary colloidal system with tunable interactions. The particle positions are extracted from microscope images and order parameters are extracted by image processing…
Magnetic fields interact with biological cells affecting them in variety of ways which are usually hard to predict. Among them, it was observed that strong fields can align dividing cells in a preferred direction. It was also demonstrated…
A new type of microfluidic system for biological cell manipulation, a CMOS/microfluidic hybrid, is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a…
The use of drugs or radiation to attack cancerous cells often leaves the treatment material within the body where it could affect healthy cells or damages healthy tissue; as is the case with traditional invasive surgery. An alternative…
Tumor organoid-on-a-chip platforms represent a cutting-edge fusion of patient-derived organoids with microfluidic technologies, offering unprecedented capabilities for personalized cancer research. These systems overcome limitations of…
Self-organization of magnetic materials is an emerging and active field. An overview of the use of self-organization for magnetic purposes is given, with a view to illustrate aspects that cannot be covered by lithography. A first set of…
Microelectromagnet devices, a ring trap and a matrix, were developed for the microscopic control of biological systems. The ring trap is a circular Au wire with an insulator on top. The matrix has two arrays of straight Au wires, one array…
We present a method and model for the direct and continuous separation of red and white blood cells in plasma. The method is implemented at the microscale using a microfluidic system that consists of an array of integrated soft-magnetic…
Magnetic nanoparticle-based hyperthermia has emerged as a promising therapeutic modality for treating malignant solid tumors that exhibit resistance to conventional cancer treatments, including chemotherapy and radiation. Despite the…
This paper presents an overview and discussion of magnetocapillary self-assemblies. New results are presented, in particular concerning the possible development of future applications. These self-organizing structures possess the notable…
Biomedical and biochemical processes in paper-based microfluidic devices often deal with mixing of two analytes to perform important functions. Uniform mixing of analytes in paper matrix is a challenging proposition, often necessitating…
We propose a new concept of magnetic focusing for targeting and accumulation of functionalized superparamagnetic nanoparticles in living organs through composite configurations of different permanent magnets. The proposed setups fulfill two…
We study the formation and dynamics of dipolar rings composed by microscopic ferromagnetic ellipsoids, which self-assemble in water by switching the direction of the applied field. We show how to manipulate these fragile structures and…
Living systems are capable of locomotion, reconfiguration, and replication. To perform these tasks, cells spatiotemporally coordinate the interactions of force-generating, "active" molecules that create and manipulate non-equilibrium…
We present a method for the direct and continuous separation of red and white blood cells from plasma at the microscale. The method is implemented in a microfluidic system with magnetic functionality. The fluidic structure within the…