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LiDRoSIS is an automated MATLAB-Python software suite for the segmentation and quantification of lipid droplets (LDs) and reactive oxygen species (ROS) in fluorescence microscopy images of irradiated A549 and MCF7 cells exposed to…

Medical Physics · Physics 2026-01-22 Marco Ferreira , Ana Belchior , Teresa Pinheiro , Gil Alves , Maria Lopes

Proteomic matrix-assisted laser desorption/ionisation (MALDI) linear time-of-flight (TOF) mass spectrometry (MS) may be used to produce protein profiles from biological samples with the aim of discovering biomarkers for disease. However,…

Quantitative Methods · Quantitative Biology 2016-03-24 Tyman E. Stanford , Christopher J. Bagley , Patty J. Solomon

Despite its improvements in coding performance compared to traditional codecs, Learned Image Compression (LIC) suffers from large computational costs for storage and deployment. Model quantization offers an effective solution to reduce the…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Md Adnan Faisal Hossain , Zhihao Duan , Fengqing Zhu

Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm [OMSSA], specificity is calculated by…

Quantitative Methods · Quantitative Biology 2007-05-23 Lewis Y. Geer , Sanford P. Markey , Jeffrey A. Kowalak , Lukas Wagner , Ming Xu , Dawn M. Maynard , Xiaoyu Yang , Wenyao Shi , Stephen H. Bryant

Spectral clustering is a celebrated algorithm that partitions objects based on pairwise similarity information. While this approach has been successfully applied to a variety of domains, it comes with limitations. The reason is that there…

Statistics Theory · Mathematics 2018-05-24 Kwangjun Ahn , Kangwook Lee , Changho Suh

Searching for novel molecules with desired chemical properties is crucial in drug discovery. Existing work focuses on developing neural models to generate either molecular sequences or chemical graphs. However, it remains a big challenge to…

Biomolecules · Quantitative Biology 2021-03-22 Yutong Xie , Chence Shi , Hao Zhou , Yuwei Yang , Weinan Zhang , Yong Yu , Lei Li

Reliable parameter extraction from experimental data is central to quantitative analysis in spectroscopy, diffraction, photoluminescence, chromatography, microscopy, and time-resolved measurements. We present FitED, a Python-based desktop…

Data Analysis, Statistics and Probability · Physics 2026-05-04 Mustafa Mahmoud Aboulsaad

Large language models~(LLMs) have recently demonstrated promising performance in many tasks. However, the high storage and computational cost of LLMs has become a challenge for deploying LLMs. Weight quantization has been widely used for…

Machine Learning · Computer Science 2025-02-11 Wen-Pu Cai , Ming-Yang Li , Wu-Jun Li

Goal-oriented de novo molecule design, namely generating molecules with specific property or substructure constraints, is a crucial yet challenging task in drug discovery. Existing methods, such as Bayesian optimization and reinforcement…

Computational Engineering, Finance, and Science · Computer Science 2025-02-28 Chuanliu Fan , Ziqiang Cao , Zicheng Ma , Nan Yu , Yimin Peng , Jun Zhang , Yiqin Gao , Guohong Fu

Semi-supervised learning for medical image segmentation presents a unique challenge of efficiently using limited labeled data while leveraging abundant unlabeled data. Despite advancements, existing methods often do not fully exploit the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Bin Zhao , Chunshi Wang , Shuxue Ding

Quantization is an indispensable technique for serving Large Language Models (LLMs) and has recently found its way into LoRA fine-tuning. In this work we focus on the scenario where quantization and LoRA fine-tuning are applied together on…

Computation and Language · Computer Science 2023-11-29 Yixiao Li , Yifan Yu , Chen Liang , Pengcheng He , Nikos Karampatziakis , Weizhu Chen , Tuo Zhao

Supervised learning techniques are at the center of many tasks in remote sensing. Unfortunately, these methods, especially recent deep learning methods, often require large amounts of labeled data for training. Even though satellites…

Machine Learning · Computer Science 2021-08-03 Pablo Gómez , Gabriele Meoni

Laboratory measurements often use several instruments to fully explore the relevant parameter space; such as, an external lock-in amplifier, an electromagnet, an RF generator, etc.. Ordinarily, these instruments have to be individually…

Instrumentation and Detectors · Physics 2024-06-25 Brad M. Goff , Jay A. Gupta

Despite the proliferation of diverse hardware accelerators (e.g., NPU, TPU, DPU), deploying deep learning models on edge devices with fixed-point hardware is still challenging due to complex model quantization and conversion. Existing model…

Machine Learning · Computer Science 2023-08-07 Manasa Manohara , Sankalp Dayal , Tariq Afzal , Rahul Bakshi , Kahkuen Fu

We propose MCGrad, a novel and scalable multicalibration algorithm. Multicalibration - calibration in subgroups of the data - is an important property for the performance of machine learning-based systems. Existing multicalibration methods…

Decision making under uncertainty often requires choosing packages, or bags of tuples, that collectively optimize expected outcomes while limiting risks. Processing Stochastic Package Queries (SPQs) involves solving very large optimization…

Databases · Computer Science 2025-04-03 Riddho R. Haque , Anh L. Mai , Matteo Brucato , Azza Abouzied , Peter J. Haas , Alexandra Meliou

Tandem Mass Spectrometry is a cornerstone technique for identifying unknown small molecules in fields such as metabolomics, natural product discovery and environmental analysis. However, certain aspects, such as the probabilistic…

Artificial Intelligence · Computer Science 2026-01-19 Laura Mismetti , Marvin Alberts , Andreas Krause , Mara Graziani

Magnetic Resonance Fingerprinting (MRF) is an emerging technology with the potential to revolutionize radiology and medical diagnostics. In comparison to traditional magnetic resonance imaging (MRI), MRF enables the rapid, simultaneous,…

In remote sensing, images acquired by various earth observation satellites tend to have either a high spatial and low spectral resolution or vice versa. Pansharpening is a technique which aims to improve spatial resolution of multispectral…

Computer Vision and Pattern Recognition · Computer Science 2015-11-17 Shailesh Panchal , Rajesh Thakker

Analyzing the dynamical properties of mobile objects requires to extract trajectories from recordings, which is often done by tracking movies. We compiled a database of two-dimensional movies for very different biological and physical…

Quantitative Methods · Quantitative Biology 2021-06-09 Benjamin Gallois , Raphaël Candelier