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Although microarrays are routine analysis tools in biomedical research, they still yield noisy output that often requires experimental confirmation. Many studies have aimed at optimizing probe design and statistical analysis to tackle this…

Quantitative Methods · Quantitative Biology 2015-06-15 Alex E Pozhitkov , Peter A Noble , Jaroslaw Bryk , Diethard Tautz

In our previous work, a reduced order model (ROM) for a stochastic system was made, where noisy data was projected onto principal component analysis (PCA)-derived basis vectors to obtain an accurate reconstruction of the noise-free data.…

Numerical Analysis · Mathematics 2017-02-07 Indika Udagedara , Brian Helenbrook , Aaron Luttman , Jared Catenacci

Principal component analysis (PCA) is a key tool in the field of data dimensionality reduction that is useful for various data science problems. However, many applications involve heterogeneous data that varies in quality due to noise…

Machine Learning · Statistics 2023-11-14 Javier Salazar Cavazos , Jeffrey A. Fessler , Laura Balzano

In safety-critical deep learning applications robustness measurement is a vital pre-deployment phase. However, existing robustness verification methods are not sufficiently practical for deploying machine learning systems in the real world.…

Machine Learning · Computer Science 2022-07-06 Tianle Zhang , Wenjie Ruan , Jonathan E. Fieldsend

Accurate predictions of pollutant concentrations at new locations are often of interest in air pollution studies on fine particulate matters (PM$_{2.5}$), in which data is usually not measured at all study locations. PM$_{2.5}$ is also a…

Applications · Statistics 2020-05-19 Phuong T. Vu , Timothy V. Larson , Adam A. Szpiro

Simulation-based probabilistic risk assessment (SPRA) is a systematic and comprehensive methodology that has been used and refined over the past few decades to evaluate the risks associated with complex systems. SPRA models are well…

Systems and Control · Electrical Eng. & Systems 2022-07-27 Tarannom Parhizkar

Robust machine learning for regulatory genomics is studied under biologically and technically induced distribution shifts. Deep convolutional and attention based models achieve strong in distribution performance on DNA regulatory sequence…

Genomics · Quantitative Biology 2026-02-20 Yiyao Yang

Principal Component Analysis (PCA) has been widely used for dimensionality reduction and feature extraction. Robust PCA (RPCA), under different robust distance metrics, such as l1-norm and l2, p-norm, can deal with noise or outliers to some…

Machine Learning · Computer Science 2021-06-29 Zhao Kang , Hongfei Liu , Jiangxin Li , Xiaofeng Zhu , Ling Tian

We study efficiency improvements in randomized experiments for estimating a vector of potential outcome means using regression adjustment (RA) when there are more than two treatment levels. We show that linear RA which estimates separate…

Econometrics · Economics 2025-01-13 Akanksha Negi , Jeffrey M. Wooldridge

The evaluation of abstractive summarization models typically uses test data that is identically distributed as training data. In real-world practice, documents to be summarized may contain input noise caused by text extraction artifacts or…

Computation and Language · Computer Science 2023-12-05 Kundan Krishna , Yao Zhao , Jie Ren , Balaji Lakshminarayanan , Jiaming Luo , Mohammad Saleh , Peter J. Liu

Root Cause Analysis (RCA) is becoming ever more critical as modern systems grow in complexity, volume of data, and interdependencies. While traditional RCA methods frequently rely on correlation-based or rule-based techniques, these…

Artificial Intelligence · Computer Science 2025-03-04 Ahmed Dawoud , Shravan Talupula

The analysis of pulsar timing data, especially in pulsar timing array (PTA) projects, has encountered practical difficulties: evaluating the likelihood and/or correlation-based statistics can become prohibitively computationally expensive…

Instrumentation and Methods for Astrophysics · Physics 2012-11-16 Rutger van Haasteren

We present $\textbf{P}$robabilistically $\textbf{T}$ightened $\textbf{Li}$near $\textbf{R}$elaxation-based $\textbf{P}$erturbation $\textbf{A}$nalysis ($\texttt{PT-LiRPA}$), a novel framework that combines over-approximation techniques from…

Machine Learning · Computer Science 2026-01-01 Luca Marzari , Ferdinando Cicalese , Alessandro Farinelli

As parallel codes are scaled to larger computing systems, performance models play a crucial role in identifying potential bottlenecks. However, constructing these models analytically is often challenging. Empirical models based on…

Principal component analysis (PCA) is a classical and ubiquitous method for reducing data dimensionality, but it is suboptimal for heterogeneous data that are increasingly common in modern applications. PCA treats all samples uniformly so…

Statistics Theory · Mathematics 2021-12-02 David Hong , Kyle Gilman , Laura Balzano , Jeffrey A. Fessler

Accurately determining resonance frequencies and quality factors (Q) is crucial in accelerator physics and radiofrequency engineering, as these factors have direct impacts on system design, operational stability, and research results. The…

Accelerator Physics · Physics 2025-10-08 Kerem Semiz

Recurrence quantification analysis (RQA) is a widely used tool for studying complex dynamical systems, but its standard implementation requires computationally expensive calculations of recurrence plots (RPs) and line length histograms.…

Chaotic Dynamics · Physics 2026-01-06 Norbert Marwan

Accumulation of standardized data collections is opening up novel opportunities for holistic characterization of genome function. The limited scalability of current preprocessing techniques has, however, formed a bottleneck for full…

Quantitative Methods · Quantitative Biology 2013-04-09 Leo Lahti , Aurora Torrente , Laura L. Elo , Alvis Brazma , Johan Rung

Single-cell RNA-seq provides detailed molecular snapshots of individual cells but is notoriously noisy. Variability stems from biological differences and technical factors, such as amplification bias and limited RNA capture efficiency,…

Machine Learning · Computer Science 2026-02-27 Victor Chardès

Robust principal component analysis (RPCA) is a widely used technique for recovering low-rank structure from matrices with missing entries and sparse, possibly large-magnitude corruptions. Although numerous algorithms achieve accurate point…

Methodology · Statistics 2026-03-17 Liangliang Yuan , Lei Wang , Quan Kong , Liuhua Peng
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