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Intensity-modulated radiation therapy (IMRT) allows for the design of customized, highly-conformal treatments for cancer patients. Creating IMRT treatment plans, however, is a mathematically complex process, which is often tackled in…

Optimization and Control · Mathematics 2022-03-18 Danielle A. Ripsman , Thomas G. Purdie , Timothy C. Y. Chan , Houra Mahmoudzadeh

Dynamic partial reconfiguration (DPR) allows one region of an field-programmable gate array (FPGA) fabric to be reconfigured without affecting the operations on the rest of the fabric. To use an FPGA as a dynamically shared compute…

Hardware Architecture · Computer Science 2017-10-26 Marie Nguyen , James C. Hoe

Treatment planning, which is a critical component of the radiotherapy workflow, is typically carried out by a medical physicist in a time-consuming trial-and-error manner. Previous studies have proposed knowledge-based or…

Image and Video Processing · Electrical Eng. & Systems 2024-03-29 Yiwen Zhang , Chuanpu Li , Liming Zhong , Zeli Chen , Wei Yang , Xuetao Wang

The dynamic mode decomposition (DMD) has become a leading tool for data-driven modeling of dynamical systems, providing a regression framework for fitting linear dynamical models to time-series measurement data. We present a simple…

Numerical Analysis · Mathematics 2017-04-11 Travis Askham , J. Nathan Kutz

Optimization is an important module of modern machine learning applications. Tremendous efforts have been made to accelerate optimization algorithms. A common formulation is achieving a lower loss at a given time. This enables a…

Machine Learning · Computer Science 2025-05-29 Zhonglin Xie , Yiman Fong , Haoran Yuan , Zaiwen Wen

We study two-stage distributionally robust optimization (DRO) problems with decision-dependent information discovery (DDID) wherein (a portion of) the uncertain parameters are revealed only if an (often costly) investment is made in the…

Optimization and Control · Mathematics 2025-10-07 Qing Jin , Angelos Georghiou , Phebe Vayanos , Grani A. Hanasusanto

We present a general framework of designing efficient dynamic approximate algorithms for optimization on undirected graphs. In particular, we develop a technique that, given any problem that admits a certain notion of vertex sparsifiers,…

Data Structures and Algorithms · Computer Science 2020-05-06 Li Chen , Gramoz Goranci , Monika Henzinger , Richard Peng , Thatchaphol Saranurak

Douglas-Rachford splitting and its equivalent dual formulation ADMM are widely used iterative methods in composite optimization problems arising in control and machine learning applications. The performance of these algorithms depends on…

Optimization and Control · Mathematics 2019-06-28 Jacob H. Seidman , Mahyar Fazlyab , Victor M. Preciado , George J. Pappas

It is often the case that the computed optimal solution of an optimization problem cannot be implemented directly, irrespective of data accuracy, due to either (i) technological limitations (such as physical tolerances of machines or…

Optimization and Control · Mathematics 2014-05-21 Han Men , Robert M. Freund , Ngoc C. Nguyen , Joel Saa-Seoane , Jaime Peraire

Molecular optimization is a crucial aspect of drug discovery, aimed at refining molecular structures to enhance drug efficacy and minimize side effects, ultimately accelerating the overall drug development process. Many molecular…

Biomolecules · Quantitative Biology 2025-05-15 Kun Li , Xiantao Cai , Jia Wu , Shirui Pan , Huiting Xu , Bo Du , Wenbin Hu

This paper addresses the challenge of dynamic multi-objective optimization problems (DMOPs) by introducing novel approaches for accelerating prediction strategies within the evolutionary algorithm framework. Since the objectives of DMOPs…

Neural and Evolutionary Computing · Computer Science 2024-11-14 Ru Lei , Lin Li , Rustam Stolkin , Bin Feng

We propose a new method for optimistic planning in infinite-horizon discounted Markov decision processes based on the idea of adding regularization to the updates of an otherwise standard approximate value iteration procedure. This…

Machine Learning · Computer Science 2023-06-16 Antoine Moulin , Gergely Neu

Differentiable programming, enabled by automatic differentiation (AD), provides a robust framework for gradient-based optimization in computational plasma physics. While optimization is often only used towards design, we demonstrate that it…

Plasma Physics · Physics 2026-03-13 A. S. Joglekar , A. G. R. Thomas , A. L. Milder , K. G. Miller , J. P. Palastro , D. H. Froula

The \textit{de facto} paradigm for applying dense retrieval (DR) to new tasks involves fine-tuning a pre-trained model for a specific task. However, this paradigm has two significant limitations: (1) It is difficult adapt the DR to a new…

Information Retrieval · Computer Science 2026-02-27 Zhan Su , Fengran Mo , Jinghan Zhang , Yuchen Hui , Jia Ao Sun , Bingbing Wen , Jian-Yun Nie

Accurate and robust medical image segmentation is fundamental and crucial for enhancing the autonomy of computer-aided diagnosis and intervention systems. Medical data collection normally involves different scanners, protocols, and…

Image and Video Processing · Electrical Eng. & Systems 2023-06-07 An Wang , Mobarakol Islam , Mengya Xu , Hongliang Ren

Adaptive sampling algorithms are modern and efficient methods that dynamically adjust the sample size throughout the optimization process. However, they may encounter difficulties in risk-averse settings, particularly due to the challenge…

Optimization and Control · Mathematics 2025-02-17 Sandra Pieraccini , Tommaso Vanzan

In this paper, we introduce a technique to enhance the computational efficiency of solution algorithms for high-dimensional discrete simulation-based optimization problems. The technique is based on innovative adaptive partitioning…

Optimization and Control · Mathematics 2024-12-04 Jing Lu , Tianli Zhou , Carolina Osorio

A common strategy today to generate efficient locomotion movements is to split the problem into two consecutive steps: the first one generates the contact sequence together with the centroidal trajectory, while the second one computes the…

Robotics · Computer Science 2019-04-11 Rohan Budhiraja , Justin Carpentier , Carlos Mastalli , Nicolas Mansard

Existing batch size selection approaches in distributed machine learning rely on static allocation or simplistic heuristics that fail to adapt to heterogeneous, dynamic computing environments. We present DYNAMIX, a reinforcement learning…

Machine Learning · Computer Science 2025-10-10 Yuanjun Dai , Keqiang He , An Wang

The definition of factor space and a unified optimization based classification model were developed for linear programming. Intelligent behaviour appeared in a decision process can be treated as a point y, the dynamic state observed and…

Optimization and Control · Mathematics 2021-01-12 Jing He , Qi-Wei Kong , Ho-Chung Lui , Hai-Tao Liu , Yi-Mu Ji , Hai-Chang Yao , Mo-Zhengfu Liu