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In this paper, we study an optimal control problem for a macroscopic mechanical tumour model based on the phase field approach. The model couples a Cahn--Hilliard type equation to a system of linear elasticity and a reaction-diffusion…

Optimization and Control · Mathematics 2021-04-21 Harald Garcke , Kei Fong Lam , Andrea Signori

Charge unbalance is one of the key issues for series-connected Lithium-ion cells. Within this context, model-based optimization strategies have proven to be the most effective. In the present paper, an ad-hoc electrochemical model, tailored…

Systems and Control · Computer Science 2019-02-07 Andrea Pozzi , Massimo Zambelli , Antonella Ferrara , Davide Martino Raimondo

We demonstrate that our recently developed theory of electric field wave propagation in anisotropic and inhomogeneous brain tissues, which has been shown to explain a broad range of observed coherent synchronous brain electrical processes,…

Biological Physics · Physics 2024-03-27 Vitaly L. Galinsky , Lawrence R. Frank

Understanding how stimuli and synaptic connectivity in uence the statistics of spike patterns in neural networks is a central question in computational neuroscience. Maximum Entropy approach has been successfully used to characterize the…

Biological Physics · Physics 2016-11-26 Rodrigo Cofre , Bruno Cessac

We analyze the effect of weak-noise-induced transitions on the dynamics of the FitzHugh-Nagumo neuron model in a bistable state consisting of a stable fixed point and a stable unforced limit cycle. Bifurcation and slow-fast analysis give…

Dynamical Systems · Mathematics 2017-06-02 Marius E. Yamakou , Jürgen Jost

A single neuron is known to generate almost identical spike trains when the same fluctuating input is repeatedly applied. Here, we study the reliability of spike firing in a pulse-coupled network of oscillator neurons receiving fluctuating…

Adaptation and Self-Organizing Systems · Physics 2015-05-13 Jun-nosuke Teramae , Tomoki Fukai

We present a theoretical study of the optimal control of a qubit interacting with a structured environment. We consider a model system in which the bath is a bosonic reservoir at zero temperature and the qubit frequency is the only control…

Quantum Physics · Physics 2022-10-04 Quentin Ansel , Jonas Fischer , Dominique Sugny , Bruno Bellomo

Reduced models of neuronal activity such as Integrate-and-Fire models allow a description of neuronal dynamics in simple, intuitive terms and are easy to simulate numerically. We present a method to fit an Integrate-and-Fire-type model of…

Neurons and Cognition · Quantitative Biology 2020-04-03 Renaud Jolivet , Wulfram Gerstner

The recently introduced discrete power-based control (Ruderman (2024b)) reduces largely the communication efforts in the control loop when compensating for the marginally damped or even slowly diverging output oscillations. The control…

Systems and Control · Electrical Eng. & Systems 2025-04-24 Michael Ruderman , Denis Efimov

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

Recurrent neural networks are powerful tools for understanding and modeling computation and representation by populations of neurons. Continuous-variable or "rate" model networks have been analyzed and applied extensively for these…

Neurons and Cognition · Quantitative Biology 2016-01-29 Brian DePasquale , Mark M. Churchland , L. F. Abbott

The generation of spikes by neurons is energetically a costly process and the evaluation of the metabolic energy required to maintain the signalling activity of neurons a challenge of practical interest. Neuron models are frequently used to…

Chaotic Dynamics · Physics 2015-06-04 A. Moujahid , A. d'Anjou , F. J. Torrealdea

This paper introduces a class of stochastic models of interacting neurons with emergent dynamics similar to those seen in local cortical populations, and compares them to very simple reduced models driven by the same mean excitatory and…

Neurons and Cognition · Quantitative Biology 2017-11-07 Yao Li , Logan Chariker , Lai-Sang Young

Dynamic excitatory-inhibitory (E-I) balance is a paradigmatic mechanism invoked to explain the irregular low firing activity observed in the cortex. However, we will show that the E-I balance can be at the origin of other regimes observable…

Neurons and Cognition · Quantitative Biology 2023-11-13 Hongjie Bi , Matteo Di Volo , Alessandro Torcini

Synchronized oscillations in networks of inhibitory and excitatory coupled bursting neurons are common in a variety of neural systems from central pattern generators to human brain circuits. One example of the latter is the subcortical…

Neurons and Cognition · Quantitative Biology 2011-09-21 Choongseok Park , Leonid L. Rubchinsky

This paper considers optimal input design when the intended use of the identified model is to construct a feed-forward controller based on measurable disturbances. The objective is to find a minimum power excitation signal to be used in…

Systems and Control · Computer Science 2013-03-14 Per Hägg , Bo Wahlberg

We study the spike statistics of neurons in a network with dynamically balanced excitation and inhibition. Our model, intended to represent a generic cortical column, comprises randomly connected excitatory and inhibitory leaky…

Neurons and Cognition · Quantitative Biology 2007-05-23 Alexander Lerchner , Cristina Ursta , John Hertz , Mandana Ahmadi , Pauline Ruffiot

Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute…

Neurons and Cognition · Quantitative Biology 2022-10-25 Veronika Koren , Stefano Panzeri

In many real-world oscillator systems, the phase response curves are highly heterogeneous. However, dynamics of heterogeneous oscillator networks has not been seriously addressed. We propose a theoretical framework to analyze such a system…

Pattern Formation and Solitons · Physics 2009-11-13 Yasuhiro Tsubo , Jun-nosuke Teramae , Tomoki Fukai

In this paper we detail a phase lagging model of brain response to external stimuli. The model is derived using the basic laws of physics like conservation of energy law. This model eliminates the paradox of instantaneous propagation of the…

Neurons and Cognition · Quantitative Biology 2012-05-21 Karthik Seetharaman , Hamidreza Namazi , Vladimir V. Kulish