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In this paper, we investigate the fundamental limits on how the inter- spike time of a neuron oscillator can be perturbed by the application of a bounded external control input (a current stimulus) with zero net electric charge…

Optimization and Control · Mathematics 2012-11-20 Isuru S. Dasanayake , Jr-Shin Li

In this article, we study optimal control problems of spiking neurons whose dynamics are described by a phase model. We design minimum-power current stimuli (controls) that lead to targeted spiking times of neurons, where the cases with…

Dynamical Systems · Mathematics 2010-11-18 Isuru Dasanayake , Jr-Shin Li

In this paper, we derive the minimum-energy periodic control that entrains an ensemble of structurally similar neural oscillators to a desired frequency. The state space representation of a nominal oscillator is reduced to a phase model by…

Neurons and Cognition · Quantitative Biology 2012-02-24 Anatoly Zlotnik , Jr-Shin Li

We use conductance based neuron models and the mathematical modeling of Optogenetics to define controlled neuron models and we address the minimal time control of these affine systems for the first spike from equilibrium. We apply tools of…

Optimization and Control · Mathematics 2016-07-20 Vincent Renault , Michèle Thieullen , Emmanuel Trélat

Synchronization of oscillations is a phenomenon prevalent in natural, social, and engineering systems. Controlling synchronization of oscillating systems is motivated by a wide range of applications from neurological treatment of…

Optimization and Control · Mathematics 2015-03-19 Jr-Shin Li , Isuru Dasanayake , Justin Ruths

We derive optimal periodic controls for entrainment of a self-driven oscillator to a desired frequency. The alternative objectives of minimizing power and maximizing frequency range of entrainment are considered. A state space…

Chaotic Dynamics · Physics 2011-09-27 Anatoly Zlotnik , Jr-Shin Li

Electrical brain stimulation relies on externally applied currents to modulate neural activity, but safety constraints require each stimulation cycle to be charge-balanced, enforcing a zero net injected charge. However, how such…

Systems and Control · Electrical Eng. & Systems 2025-12-09 Yuzhen Qin , Zonglin Liu , Marcel van Gerven

Periodic pulse train stimulation is generically used to study the function of the nervous system and to counteract disease-related neuronal activity, e.g., collective periodic neuronal oscillations. The efficient control of neuronal…

Adaptation and Self-Organizing Systems · Physics 2020-08-05 Kestutis Pyragas , Augustinas P. Fedaravičius , Tatjana Pyragienė

Excitation-inhibition (E-I) balance is ubiquitously observed in the cortex. Recent studies suggest an intriguing link between balance on fast timescales, tight balance, and efficient information coding with spikes. We further this…

Neurons and Cognition · Quantitative Biology 2021-05-04 Qianyi Li , Cengiz Pehlevan

Neurons communicate with downstream systems via sparse and incredibly brief electrical pulses, or spikes. Using these events, they control various targets such as neuromuscular units, neurosecretory systems, and other neurons in connected…

Neurons and Cognition · Quantitative Biology 2026-03-17 Paolo Agliati , André Urbano , Pablo Lanillos , Nasir Ahmad , Marcel van Gerven , Sander Keemink

This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a…

Neurons and Cognition · Quantitative Biology 2018-09-06 Adam Noel , Shayan Monabbati , Dimitrios Makrakis , Andrew W. Eckford

We study a problem of designing ``robust'' external excitations for control and synchronization of an assembly of homotypic harmonic oscillators representing so-called theta neurons. The model of theta neurons (Theta model) captures, in…

Optimization and Control · Mathematics 2024-09-23 Roman Chertovskih , Nikolay Pogodaev , Maxim Staritsyn , Joaquim Da Silva Sewane , Antonio Pedro Aguiar

This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a…

Neurons and Cognition · Quantitative Biology 2020-04-24 Adam Noel , Shayan Monabbati , Dimitrios Makrakis , Andrew W. Eckford

Dynamical balance of excitation and inhibition is usually invoked to explain the irregular low firing activity observed in the cortex. We propose a robust nonlinear balancing mechanism for a random network of spiking neurons, which works…

Disordered Systems and Neural Networks · Physics 2025-05-29 Antonio Politi , Alessandro Torcini

We investigate the optimal charging processes for several models of quantum batteries, finding how to maximize the energy stored in a given battery with a finite-time modulation of a set of external fields. We approach the problem using…

Precise control of signal propagation in modular neural networks represents a fundamental challenge in computational neuroscience. We establish a framework for identifying optimal control nodes that maximize stimulus transmission between…

Neurons and Cognition · Quantitative Biology 2025-08-18 Bulat Batuev , Arsenii Onuchin , Sergey Sukhov

Motivated by deep brain stimulation treatment of neural disorders such as Parkinson's disease, it has been proposed that desynchronization of neural oscillators can be achieved by maximizing the Lyapunov exponent of the phase difference…

Optimization and Control · Mathematics 2025-09-25 Jeff Moehlis , Michael Zimet , Faranak Rajabi

The excitability property of spiking neurons describes their capability to output an action potential as a real-time response to an input synaptic excitation current and is central to the event-based neuromorphic computing paradigm. The…

Statistical Mechanics · Physics 2025-11-18 Léopold Van Brandt , Grégoire Brandsteert , Denis Flandre

In this paper we deal with a feedback control design for the action potential of a neuronal membrane in relation with the non-linear dynamics of the Hodgkin-Huxley mathematical model. More exactly, by using an external current as a control…

Optimization and Control · Mathematics 2020-04-22 Cecilia Cavaterra , Denis Enachescu , Gabriela Marinoschi

This article investigates the emergence of phase synchronization in a network of randomly connected neurons by chemical synapses. The study uses the classic Hodgkin-Huxley model to simulate the neuronal dynamics under the action of a train…

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