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Resource Balance Analysis (RBA) is a framework for predicting steady-state cellular growth under resource constraints. However, classical RBA formulations are static and do not capture the dynamic regulation of biosynthetic resources or…

Optimization and Control · Mathematics 2026-01-21 Saeed Sadeghi Arjmand

Aerotaxis is the particular form of chemotaxis in which oxygen plays the role of both the attractant and the repellent. Aerotaxis occurs without methylation adaptation, and it leads to fast and complete aggregation toward the most favorable…

Classical Analysis and ODEs · Mathematics 2015-06-26 Barbara "Bori" C. Mazzag

We experimentally, numerically and analytically explore the diffusive transport of active colloidal particles with sensory delay, navigating motility landscapes in which the self-propulsion speed depends on space. We show how the transport…

Statistical Mechanics · Physics 2026-04-29 Adrià Garcés , Ueli Töpfer , Lucio Isa , Demian Levis , Ignacio Pagonabarraga

We adopt the reinforcement learning algorithm to train the self-propelling agent migrating long-distance in a thermal turbulent environment. We choose the Rayleigh-B\'enard turbulent convection cell with an aspect ratio ($\Gamma$, which is…

Fluid Dynamics · Physics 2023-02-09 Ao Xu , Hua-Lin Wu , Heng-Dong Xi

Numerous studies have explored the link between bacterial swimming and the number of flagella, a distinguishing feature of motile multiflagellated bacteria. We revisit this open question using augmented slender-body theory simulations, in…

Biological Physics · Physics 2024-09-04 Maria Tătulea-Codrean , Eric Lauga

Kinetic-transport equations are, by now, standard models to describe the dynamics of populations of bacteria moving by run-and-tumble. Experimental observations show that bacteria increase their run duration when encountering an increasing…

Analysis of PDEs · Mathematics 2015-03-16 Benoît Perthame , Min Tang , Nicolas Vauchelet

Energy transfer plays a vital role in many natural and technological processes. In this work, we study the effects of mechanical motion on the excitation transfer through a chain of interacting molecules with application to biological…

Mechanical stresses stemming from environmental factors are a key determinant of cellular behavior and physiology. Yet, the role of self-induced biomechanical stresses in growing bacterial colonies has remained largely unexplored. Here, we…

Soft Condensed Matter · Physics 2023-11-27 René Wittmann , G. H. Philipp Nguyen , Hartmut Löwen , Fabian J. Schwarzendahl , Anupam Sengupta

Cell motility is one of the most fundamental phenomena underlying biological processes that maintain living organisms alive. Here we introduce a simple model to describe the motility of cells which include not only time-correlated internal…

Biological Physics · Physics 2022-07-13 T. N. Azevedo , L. G. Rizzi

Natural selection has shaped the evolution of cells and multi-cellular organisms such that social cooperation can often be preferred over an individualistic approach to metabolic regulation. This paper extends a framework for dynamic…

Molecular Networks · Quantitative Biology 2021-01-28 David S. Tourigny

A typical signature of charge extraction in disordered organic systems is dispersive transport, which implies a distribution of charge carrier mobilities that negatively impact on device performance. Dispersive transport has been commonly…

Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion. It is an open question…

Biological Physics · Physics 2017-09-20 Sarah Klein , Cécile Appert-Rolland , Ludger Santen

Intracellular transport of organelles is fundamental to cell function and health. The mounting evidence suggests that this transport is in fact anomalous. However, the reasons for the anomaly is still under debate. We examined experimental…

Subcellular Processes · Quantitative Biology 2018-12-10 Nickolay Korabel , Thomas A. Waigh , Sergei Fedotov , Viki J. Allan

Biomolecular machines transduce between different forms of energy. These machines make directed progress and increase their speed by consuming free energy, typically in the form of nonequilibrium chemical concentrations. Machine dynamics…

Statistical Mechanics · Physics 2018-10-05 Aidan I Brown , David A Sivak

Dynamic properties of molecular motors that fuel their motion by actively interacting with underlying molecular tracks are studied theoretically via discrete-state stochastic ``burnt-bridge'' models. The transport of the particles is viewed…

Soft Condensed Matter · Physics 2009-11-13 Maxim N. Artyomov , Alexander Yu. Morozov , Ekaterina Pronina , Anatoly B. Kolomeisky

Cells are complex structures which require considerable amounts of organization via transport of large intracellular cargo. While passive diffusion is often sufficiently fast for the transport of smaller cargo, active transport is necessary…

Biomolecules · Quantitative Biology 2018-08-29 Robert Blackwell , David Jung , Mona Bukenberger , Ana-Sunčana Smith

Optical tracking in vivo experiments reveal that diffusion of particles in biological cells is strongly enhanced in the presence of ATP and the experimental data for animal cells could previously be reproduced within a phenomenological…

Soft Condensed Matter · Physics 2017-03-22 Kento Yasuda , Ryuichi Okamoto , Shigeyuki Komura , Alexander S. Mikhailov

Self-sustained turbulent structures have been observed in a wide range of living fluids, yet no quantitative theory exists to explain their properties. We report experiments on active turbulence in highly concentrated 3D suspensions of…

Recent observations demonstrate that densely packed tissues exhibit features of glassy dynamics, such as caging behavior and dynamical heterogeneities, although it has remained unclear how single-cell properties control this behavior. Here…

Soft Condensed Matter · Physics 2014-02-19 Dapeng Bi , J. H. Lopez , J. M. Schwarz , M. Lisa Manning

Recent research has shown that motile cells can adapt their mode of propulsion to the mechanical properties of the environment in which they find themselves--crawling in some environments while swimming in others. The latter can involve…

Biological Physics · Physics 2018-05-24 Hao Wu , Marco Avila Ponce de Leon , Hans G. Othmer
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