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In the presence of multiscale dynamics in a reaction network, direct simulation methods become inefficient as they can only advance the system on the smallest scale. This work presents stochastic averaging techniques to accelerate…

Probability · Mathematics 2016-03-23 Araz Hashemi , Marcel Nunez , Petr Plechac , Dionisios G. Vlachos

The standard two-step model of homogeneous-catalyzed reactions had been theoretically analyzed at various levels of approximations from time to time. The primary aim was to check the validity of the quasi-steady-state approximation, and…

Chemical Physics · Physics 2019-11-14 Kamal Bhattacharyya , Sharmistha Dhatt

Answer Set Programming (ASP) is a prominent rule-based language for knowledge representation and reasoning with roots in logic programming and non-monotonic reasoning. The aim to capture the essence of removing (ir)relevant details in ASP…

Artificial Intelligence · Computer Science 2023-12-14 Zeynep G. Saribatur , Stefan Woltran

Concurrent constraint programming (ccp) is a well-established model for concurrency that singles out the fundamental aspects of asynchronous systems whose agents (or processes) evolve by posting and querying (partial) information in a…

Programming Languages · Computer Science 2012-12-18 Andrés Aristizábal , Filippo Bonchi , Luis Pino , Frank Valencia

The analysis of concurrent and reactive systems is based to a large degree on various notions of process equivalence, ranging, on the so-called linear-time/branching-time spectrum, from fine-grained equivalences such as strong bisimilarity…

Logic in Computer Science · Computer Science 2014-10-17 Alexander Kurz , Stefan Milius , Dirk Pattinson , Lutz Schröder

Automata representing game-semantic models of programs are meant to operate in environments whose input-output behaviour is constrained by the rules of a game. This can lead to a notion of equivalence between states which is weaker than the…

Programming Languages · Computer Science 2012-12-18 Dan R. Ghica , Zaid Al-Zobaidi

The statistical thermodynamics of binary mixtures of polyatomic species was developed on a generalization in the spirit of the lattice-gas model and the quasi-chemical approximation (QCA). The new theoretical framework is obtained by…

Chemical Physics · Physics 2016-11-03 M. V. Dávila , P. M. Pasinetti , D. A. Matoz-Fernandez , A. J. Ramirez-Pastor

The probability distribution describing the state of a Stochastic Reaction Network evolves according to the Chemical Master Equation (CME). It is common to estimated its solution using Monte Carlo methods such as the Stochastic Simulation…

Quantitative Methods · Quantitative Biology 2015-06-18 Benjamin Hepp , Ankit Gupta , Mustafa Khammash

We consider principled alternatives to unsupervised learning in data mining by situating the learning task in the context of the subsequent analysis task. Specifically, we consider a query-answering (hypothesis-testing) task: In the…

Data Structures and Algorithms · Computer Science 2013-04-18 Brendan Juba

For a long time biologists have used visual representations of biochemical networks to gain a quick overview of important structural properties. Recently SBGN, the Systems Biology Graphical Notation, has been developed to standardise the…

Programming Languages · Computer Science 2009-10-09 Laurence Loewe , Stuart Moodie , Jane Hillston

The quasi-steady-state assumption (QSSA) is an approximation that is widely used in chemistry and chemical engineering to simplify reaction mechanisms. The key step in the method requires a solution by radicals of a system of multivariate…

Dynamical Systems · Mathematics 2025-05-16 Ophelia Adams

We introduce a general categorical framework for the definition of weak behavioural equivalences, building on and extending recent results in the field. This framework is based on parametrized saturation categories, i.e. categories whose…

Logic in Computer Science · Computer Science 2015-09-29 Tomasz Brengos , Marino Miculan , Marco Peressotti

A relation giving a minimum for the irreversible work in quasi-equilibrium processes was derived by Sekimoto et al. (K. Sekimoto and S. Sasa, J. Phys. Soc. Jpn. {\bf 66} (1997), 3326) in the framework of stochastic energetics. This relation…

Statistical Mechanics · Physics 2015-03-13 E. Sergio Santini , M. Florencia Carusela , Eduardo D. Izquierdo

We propose a universal approach for analysis and fast simulations of stiff stochastic biochemical kinetics networks, which rests on elimination of fast chemical species without a loss of information about mesoscopic, non-Poissonian…

Molecular Networks · Quantitative Biology 2009-07-07 N. A. Sinitsyn , Nicolas Hengartner , Ilya Nemenman

In this paper, we study the asymptotic behavior of a semi-linear slow-fast stochastic partial differential equation with singular coefficients. Using the Poisson equation in Hilbert space, we first establish the strong convergence in the…

Probability · Mathematics 2021-06-09 Michael Röckner , Longjie Xie , Li Yang

Linear response theory is a well-established method in physics and chemistry for exploring excitations of many-body systems. In particular, the quasiparticle random-phase approximation (QRPA) provides a powerful microscopic framework by…

Computational Physics · Physics 2025-10-17 L. Jin , A. Ravlić , P. Giuliani , K. Godbey , W. Nazarewicz

The relationship between components of biochemical network and the resulting dynamics of the overall system is a key focus of computational biology. However, as these networks and resulting mathematical models are inherently complex and…

Molecular Networks · Quantitative Biology 2015-02-13 Simon West , Lloyd J. Bridge , Michael R. H. White , Pawel Paszek , Vadim N. Biktashev

One of the basic sanity properties of a behavioural semantics is that it constitutes a congruence with respect to standard process operators. This issue has been traditionally addressed by the development of rule formats for transition…

Logic in Computer Science · Computer Science 2010-08-13 Maciej Gazda , Wan Fokkink

Pomset automata are an operational model of weak bi-Kleene algebra, which describes programs that can fork an execution into parallel threads, upon completion of which execution can join to resume as a single thread. We characterize a…

Formal Languages and Automata Theory · Computer Science 2023-06-22 Tobias Kappé , Paul Brunet , Bas Luttik , Alexandra Silva , Fabio Zanasi

Semisupervised methods inevitably invoke some assumption that links the marginal distribution of the features to the regression function of the label. Most commonly, the cluster or manifold assumptions are used which imply that the…

Statistics Theory · Mathematics 2011-12-02 Martin Azizyan , Aarti Singh , Larry Wasserman
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