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We analyze a class of chemical reaction networks under mass-action kinetics and involving multiple time-scales, whose deterministic and stochastic models display qualitative differences. The networks are inspired by gene-regulatory…

Molecular Networks · Quantitative Biology 2018-01-30 Tomislav Plesa , Radek Erban , Hans G. Othmer

Fluctuations in the abundance of molecules in the living cell may affect its growth and well being. For regulatory molecules (e.g., signaling proteins or transcription factors), fluctuations in their expression can affect the levels of…

Molecular Networks · Quantitative Biology 2009-11-13 Erel Levine , Terence Hwa

In this work, several random Boolean networks (RBN) are generated and analyzed from two characteristics: their time evolution diagram and their transition diagram. For this purpose, its randomness is estimated using three measures, of which…

Information Theory · Computer Science 2024-09-04 Manuel de J. Luevano , Alejandro Puga

In the modeling, monitoring, and control of complex networks, a fundamental problem concerns the comprehensive determination of the state of the system from limited measurements. Using power grids as example networks, we show that this…

Physics and Society · Physics 2013-01-28 Yang Yang , Jianhui Wang , Adilson E. Motter

We propose a new measure to quantify the impact of a node $i$ in controlling a directed network. This measure, called `control contribution' $\mathcal{C}_{i}$, combines the probability for node $i$ to appear in a set of driver nodes and the…

Social and Information Networks · Computer Science 2019-06-12 Yan Zhang , Antonios Garas , Frank Schweitzer

Selective rationalization improves neural network interpretability by identifying a small subset of input features -- the rationale -- that best explains or supports the prediction. A typical rationalization criterion, i.e. maximum mutual…

Machine Learning · Computer Science 2020-03-24 Shiyu Chang , Yang Zhang , Mo Yu , Tommi S. Jaakkola

Functional brain networks can change rapidly as a function of stimuli or cognitive shifts. Tracking dynamic functional connectivity is particularly challenging as it requires estimating the structure of the network at each moment as well as…

Methodology · Statistics 2024-04-30 Wan-Chi Hsin , Uri T. Eden , Emily P. Stephen

We study the high-power asymptotic behavior of the sum-rate capacity of multi-user interference networks with an equal number of transmitters and receivers. We assume that each transmitter is cognizant of the message it wishes to convey to…

Information Theory · Computer Science 2016-11-15 Amos Lapidoth , Shlomo Shamai , Michele A. Wigger

Boolean networks model finite discrete dynamical systems with complex behaviours. The state of each component is determined by a Boolean function of the state of (a subset of) the components of the network. This paper addresses the…

Artificial Intelligence · Computer Science 2020-02-28 Stéphanie Chevalier , Christine Froidevaux , Loïc Paulevé , Andrei Zinovyev

We consider the problem of predicting the time evolution of influence, the expected number of activated nodes, given a set of initially active nodes on a propagation network. To address the significant computational challenges of this…

Social and Information Networks · Computer Science 2017-01-10 Shui-Nee Chow , Xiaojing Ye , Hongyuan Zha , Haomin Zhou

Similar to intelligent multicellular neural networks controlling human brains, even single cells surprisingly are able to make intelligent decisions to classify several external stimuli or to associate them. This happens because of the fact…

Molecular Networks · Quantitative Biology 2018-11-21 Russell Bates , Oleg Blyuss , Ahmed Alsaedi , Alexey Zaikin

We prove that nested canalizing functions are the minimum-sensitivity Boolean functions for any activity ratio and we determine the functional form of this boundary which has a nontrivial fractal structure. We further observe that the…

Molecular Networks · Quantitative Biology 2024-08-14 Hamza Coban

Boolean networks are a valuable class of discrete dynamical systems models, but they remain fundamentally limited by their inability to capture multi-way interactions in their components. To remedy this limitation, we propose a model of…

Dynamical Systems · Mathematics 2024-09-02 Kevin M. Stoltz , Cliff A. Joslyn

Mathematical models of stem cell differentiation are commonly based upon the concept of subsequent cell fate decisions, each controlled by a gene regulatory network. These networks exhibit a multistable behavior and cause the system to…

Quantitative Methods · Quantitative Biology 2011-07-06 Christian Breindl , Daniella Schittler , Steffen Waldherr , Frank Allgöwer

Our daily social and political life is more and more impacted by social networks. The functioning of our living bodies is deeply dependent on biological regulation networks such as neural, genetic, and protein networks. And the physical…

Discrete Mathematics · Computer Science 2022-04-25 Jacques Demongeot , Tarek Melliti , Mathilde Noual , Damien Regnault , Sylvain Sené

This paper studies the problem of selecting a minimum-size set of input nodes to guarantee stability of a networked system in the presence of uncertainties and time delays. Current approaches to input selection in networked dynamical…

Optimization and Control · Mathematics 2017-12-13 Zhipeng Liu , Yao Long , Andrew Clark , Phillip Lee , Linda Bushnell , Daniel Kirschen , Radha Poovendran

Comparing two population means of network data is of paramount importance in a wide range of scientific applications. Many existing network inference solutions focus on global testing of entire networks, without comparing individual network…

Methodology · Statistics 2019-10-10 Yin Xia , Lexin Li

Inspired by the importance of inhibitory and excitatory couplings in the brain, we analyze the largest eigenvalue statistics of random networks incorporating such features. We find that the largest real part of eigenvalues of a network,…

Disordered Systems and Neural Networks · Physics 2013-04-30 Sanjiv Kumar Dwivedi , Sarika Jalan

We investigate Threshold Random Boolean Networks with $K = 2$ inputs per node, which are equivalent to Kauffman networks, with only part of the canalyzing functions as update functions. According to the simplest consideration these networks…

Disordered Systems and Neural Networks · Physics 2007-07-16 Florian Greil , Barbara Drossel

Many biological, technological, and social systems can be effectively described as networks of interacting subsystems. Typically, these networks are not isolated objects, but interact with their environment through both signals and…

Systems and Control · Electrical Eng. & Systems 2026-01-06 Amirhossein Nazerian , Malbor Asllani , Melvyn Tyloo , Wai Lim Ku , Francesco Sorrentino