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It is shown that a large class of events in a product probability space are highly sensitive to noise, in the sense that with high probability, the configuration with an arbitrary small percent of random errors gives almost no prediction…

Probability · Mathematics 2008-11-26 Itai Benjamini , Gil Kalai , Oded Schramm

Understanding design principles of molecular interaction networks is an important goal of molecular systems biology. Some insights have been gained into features of their network topology through the discovery of graph theoretic patterns…

Molecular Networks · Quantitative Biology 2013-01-18 David Murrugarra , Reinhard Laubenbacher

When inhibitory neurons constitute about 40% of neurons they could have an important antinociceptive role, as they would easily regulate the level of activity of other neurons. We consider a simple network of cortical spiking neurons with…

Neurons and Cognition · Quantitative Biology 2014-01-28 Fernando Montani , Emilia B. Deleglise , Osvaldo A. Rosso

The extraordinary computational power of the brain may be related in part to the fact that each of the smaller neural networks that compose it can behave transiently in many different ways, depending on its inputs. Mathematically, input…

Neurons and Cognition · Quantitative Biology 2008-03-29 Léonard Gérard , Jean-Jacques Slotine

We determine stability and attractor properties of random Boolean genetic network models with canalyzing rules for a variety of architectures. For all power law, exponential, and flat in-degree distributions, we find that the networks are…

Molecular Networks · Quantitative Biology 2007-05-23 Stuart Kauffman , Carsten Peterson , Björn Samuelsson , Carl Troein

The response of complex networks to perturbations is of utmost importance in areas as diverse as ecosystem management, emergency response, and cell reprogramming. A fundamental property of networks is that the perturbation of one node can…

Molecular Networks · Quantitative Biology 2011-05-20 Sean P. Cornelius , William L. Kath , Adilson E. Motter

We performed a numerical study on random Boolean networks with power-law rank outdegree distributions to find local structural cause for the emergence of high or low degree of coherence in binary state variables. The degree of randomness…

Cellular Automata and Lattice Gases · Physics 2007-07-02 Chikoo Oosawa , Kazuhiro Takemoto , Shogo Matsumoto , Michael A. Savageau

How the information microscopically processed by individual neurons is integrated and used in organizing the behavior of an animal is a central question in neuroscience. The coherence of neuronal dynamics over different scales has been…

Disordered Systems and Neural Networks · Physics 2020-03-11 Takashi Hayakawa , Tomoki Fukai

In this paper we present an algorithm to address the predecessor problem of feed-forward Boolean networks. We propose an probabilistic algorithm, which solves this problem in linear time with respect to the number of nodes in the network.…

Information Theory · Computer Science 2013-02-18 Johannes Georg Klotz , Martin Bossert , Steffen Schober

Highly connected recurrent neural networks often produce chaotic dynamics, meaning their precise activity is sensitive to small perturbations. What are the consequences for how such networks encode streams of temporal stimuli? On the one…

Neurons and Cognition · Quantitative Biology 2016-12-16 Guillaume Lajoie , Kevin K Lin , Jean-Philippe Thivierge , Eric Shea-Brown

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the…

Molecular Networks · Quantitative Biology 2008-05-28 Stefan Braunewell , Stefan Bornholdt

Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the interplay between a gene repertoire and the regulatory…

Molecular Networks · Quantitative Biology 2007-05-23 M. Cosentino Lagomarsino , P. Jona , B. Bassetti

Mechanisms underlying the emergence of orientation selectivity in the primary visual cortex are highly debated. Here we study the contribution of inhibition-dominated random recurrent networks to orientation selectivity, and more generally…

Neurons and Cognition · Quantitative Biology 2014-06-03 Sadra Sadeh , Stefano Cardanobile , Stefan Rotter

Characterization of the differences between biological and random networks can reveal the design principles that enable the robust realization of crucial biological functions including the establishment of different cell types. Previous…

Molecular Networks · Quantitative Biology 2020-08-26 Shubham Tripathi , David A. Kessler , Herbert Levine

We construct and investigate Boolean networks that follow a given reliable trajectory in state space, which is insensitive to fluctuations in the updating schedule, and which is also robust against noise. Robustness is quantified as the…

Biological Physics · Physics 2010-12-02 Christoph Schmal , Tiago P. Peixoto , Barbara Drossel

The dynamical organization in the presence of noise of a Boolean neural network with random connections is analyzed. For low levels of noise, the system reaches a stationary state in which the majority of its elements acquire the same…

Disordered Systems and Neural Networks · Physics 2007-05-23 Cristian Huepe , Maximino Aldana

According to the chemical reaction network theory, the topology of a certain class of chemical reaction networks, regardless of the kinetic details, sets a limit on the dynamical properties that a particular network can potentially admit;…

Molecular Networks · Quantitative Biology 2014-08-21 Jaewook Joo , Sanjeev Chauhan

It is an increasingly important problem to study conditions on the structure of a network that guarantee a given behavior for its underlying dynamical system. In this paper we report that a Boolean network may fall within the chaotic…

Molecular Networks · Quantitative Biology 2008-11-04 Winfried Just , German Enciso

We investigate the effect of noise on Random Boolean Networks. Noise is implemented as a probability $p$ that a node does not obey its deterministic update rule. We define two order parameters, the long-time average of the Hamming distance…

Biological Physics · Physics 2009-11-13 Tiago P. Peixoto , Barbara Drossel

We study two measures of the complexity of heterogeneous extended systems, taking random Boolean networks as prototypical cases. A measure defined by Shalizi et al. for cellular automata, based on a criterion for optimal statistical…

Cellular Automata and Lattice Gases · Physics 2012-06-12 Xinwei Gong , Joshua E. S. Socolar