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The present habilitation thesis in theoretical biological physics addresses two central dynamical processes in cells and organisms: (i) active motility and motility control and (ii) self-organized pattern formation. The unifying theme is…

Cell Behavior · Quantitative Biology 2018-03-21 Benjamin M. Friedrich

The propulsion of mammalian spermatozoa relies on the spontaneous periodic oscillation of their flagella. These oscillations are driven internally by the coordinated action of ATP-powered dynein motors that exert sliding forces between…

Fluid Dynamics · Physics 2022-10-13 Chenji Li , Brato Chakrabarti , Pedro Castilla , Achal Mahajan , David Saintillan

The nature of emergent collective behaviors of moving physical agents interacting with their neighborhood is a long-standing open issue in physical and biological systems alike. This calls for studies on the control of synchronization and…

Statistical Mechanics · Physics 2017-08-11 Tirthankar Banerjee , Abhik Basu

Self-propulsion and navigation due to the sensing of environmental conditions - such as durotaxis and chemotaxis - are remarkable properties of biological cells that cannot be reproduced by single-component self-propelled particles. We…

Soft Condensed Matter · Physics 2024-06-03 Clara Abaurrea-Velasco , Thorsten Auth , Gerhard Gompper

Many microorganisms swim through gels, materials with nonzero zero-frequency elastic shear modulus, such as mucus. Biological gels are typically heterogeneous, containing both a structural scaffold (network) and a fluid solvent. We analyze…

Biological Physics · Physics 2015-05-18 Henry C. Fu , Vivek B. Shenoy , Thomas R. Powers

We present experiments to study the relaxation of a nano-scale cylindrical perturbation at one of the two interfaces of a thin viscous free-standing polymeric film. Driven by capillarity, the film flows and evolves towards equilibrium by…

Soft Condensed Matter · Physics 2020-05-13 Vincent Bertin , John Niven , Howard A. Stone , Thomas Salez , Elie Raphael , Kari Dalnoki-Veress

The actomyosin cortex, a thin layer of a cross-linked polymer network near the cell surface, generates active forces that are responsible for cell shape changes. Many developmental processes that involve such cell shape changes, most…

Soft Condensed Matter · Physics 2026-02-26 Da Gao , Alexander Mietke , Rui Ma

The collective motion of dust particles during the mode-coupling induced melting of a two-dimensional plasma crystal is explored in molecular dynamics simulations. The crystal is compressed horizontally by an anisotropic confinement. This…

Plasma Physics · Physics 2015-07-17 I. Laut , C. Räth , S. Zhdanov , V. Nosenko , L. Couëdel , H. M. Thomas

The recent discovery of the striking sheet-like multicellular choanoflagellate species $Choanoeca~flexa$ that dynamically interconverts between two hemispherical forms of opposite orientation raises fundamental questions in cell and…

Soft Condensed Matter · Physics 2023-03-15 Lloyd Fung , Adam Konkol , Takuji Ishikawa , Ben Larson , Thibaut Brunet , Raymond E. Goldstein

In this fluid dynamics video, we show that low Reynolds number swimmers, such as Caenorhabditis (C.) elegans, synchronize their gait when swimming in close proximity to maximize utilization of space. Synchronization most likely results from…

Fluid Dynamics · Physics 2012-10-16 Jinzhou Yuan , Kun He Lee , David M. Raizen , Haim H. Bau

In G.I. Taylor's historic paper on swimming microorganisms, a two dimensional sheet was proposed as a model for flagellated cells passing traveling waves as a means of locomotion. Using a perturbation series, Taylor computed swimming speeds…

Fluid Dynamics · Physics 2013-02-19 Martin Sauzade , Gwynn J. Elfring , Eric Lauga

Flexible structures in an incoming perpendicular flow typically undergo elastic reconfiguration that reduces drag; however, at higher velocities, they are prone to dynamical instabilities that entail complex wake dynamics and fluctuating…

Eukaryotic cilia and flagella are chemo-mechanical oscillators capable of generating long-range coordinated motions known as metachronal waves. Pair synchronization is a fundamental requirement for these collective dynamics, but it is…

Biological Physics · Physics 2016-06-03 Douglas R. Brumley , Nicolas Bruot , Jurij Kotar , Raymond E. Goldstein , Pietro Cicuta , Marco Polin

Active swimmers are ubiquitous in nature, found in many diverse biological systems ranging from bacteria to vertebrate fish. Of particular importance are sperm cells which are swimmers that are crucial for the survival of many species…

Biological Physics · Physics 2017-11-15 James L. Kingsley , Utkan Demirci , Erkan Tuzel

Swimming cells and microorganisms are as diverse in their collective dynamics as they are in their individual shapes and propulsion mechanisms. Even for sperm cells, which have a stereotyped shape consisting of a cell body connected to a…

Fluid Dynamics · Physics 2018-06-25 S. F. Schoeller , E. E. Keaveny

Flagellated bacteria exploiting helical propulsion are known to swim along circular trajectories near surfaces. Fluid dynamics predicts this circular motion to be clockwise (CW) above a rigid surface (when viewed from inside the fluid) and…

Biological Physics · Physics 2014-07-18 Diego Lopez , Eric Lauga

According to the acoustic fluidization hypothesis, elastic waves at a characteristic frequency form inside seismic faults even in the absence of an external perturbation. These waves are able to generate a normal stress which contrasts the…

Statistical Mechanics · Physics 2018-02-14 F. Giacco , L. de Arcangelis , M. Pica Ciamarra , E. Lippiello

Biological microswimmers such as bacteria and sperm cells often encounter complex biological fluid environments. Here we use the well-known squirmer microswimmer model to show the importance of the local fluid microstructure and…

Soft Condensed Matter · Physics 2023-07-19 Andreas Zöttl

Many microorganisms live and evolve in complex fluids. Examples include mammalian spermatozoa in cervical mucus, worms (e.g., \textit{C. elegans}) in wet soil, and bacteria (e.g., \textit{H. pylori}) in our stomach lining. Due to the…

Fluid Dynamics · Physics 2022-10-21 Paulo E. Arratia

In Nature, liquids often circulate in channels textured with leaflets, cilia or porous walls that deform with the flow. These soft structures are optimized to passively control flows and inspire the design of novel microfluidic and soft…

Soft Condensed Matter · Physics 2020-08-19 Martin Brandenbourger , Adrien Dangremont , Rudolf Sprik , Corentin Coulais