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Negative control is a common technique in scientific investigations and broadly refers to the situation where a null effect (''negative result'') is expected. Motivated by a real proteomic dataset, we will present three promising and…

Methodology · Statistics 2023-03-21 Zijun Gao , Qingyuan Zhao

This work investigates multiple testing by considering minimax separation rates in the sparse sequence model, when the testing risk is measured as the sum FDR+FNR (False Discovery Rate plus False Negative Rate). First using the popular…

Statistics Theory · Mathematics 2023-08-31 Kweku Abraham , Ismael Castillo , Etienne Roquain

Feature screening for ultrahigh-dimension, in general, proceeds with two essential steps. The first step is measuring and ranking the marginal dependence between response and covariates, and the second is determining the threshold. We…

Methodology · Statistics 2022-07-28 Linsui Deng , Yilin Zhang

A systematic multiple hypothesis testing approach is applied to the search for astrophysical sources of high energy neutrinos. The method is based on the maximisation of the detection power maintaining the control of the confidence level of…

Instrumentation and Methods for Astrophysics · Physics 2010-11-24 Bruny Baret , Mathieu Labare , Daniel Bertrand

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any…

Methodology · Statistics 2010-12-21 Xu Han , Weijie Gu , Jianqing Fan

While traditional multiple testing procedures prohibit adaptive analysis choices made by users, Goeman and Solari (2011) proposed a simultaneous inference framework that allows users such flexibility while preserving high-probability bounds…

Statistics Theory · Mathematics 2021-01-05 Eugene Katsevich , Aaditya Ramdas

Efforts to develop more efficient multiple hypothesis testing procedures for false discovery rate (FDR) control have focused on incorporating an estimate of the proportion of true null hypotheses (such procedures are called adaptive) or…

Methodology · Statistics 2017-02-13 Joshua D. Habiger

We apply FDR thresholding to a non-Gaussian vector whose coordinates X_i, i=1,..., n, are independent exponential with individual means $\mu_i$. The vector $\mu =(\mu_i)$ is thought to be sparse, with most coordinates 1 but a small fraction…

Statistics Theory · Mathematics 2009-09-29 David Donoho , Jiashun Jin

Identifying areas where the signal is prominent is an important task in image analysis, with particular applications in brain mapping. In this work, we develop confidence regions for spatial excursion sets above and below a given level. We…

Methodology · Statistics 2025-04-18 Howon Ryu , Thomas Maullin-Sapey , Armin Schwartzman , Samuel Davenport

The most popular multiple testing procedures are stepwise procedures based on $P$-values for individual test statistics. Included among these are the false discovery rate (FDR) controlling procedures of Benjamini--Hochberg [J. Roy. Statist.…

Statistics Theory · Mathematics 2009-06-18 Arthur Cohen , Harold B. Sackrowitz , Minya Xu

We consider the problem of multiple hypothesis testing with generic side information: for each hypothesis $H_i$ we observe both a p-value $p_i$ and some predictor $x_i$ encoding contextual information about the hypothesis. For large-scale…

Methodology · Statistics 2018-07-26 Lihua Lei , William Fithian

Disjunct matrices, also known as cover-free families and superimposed codes, are combinatorial arrays widely used in group testing. Among their variants, those that satisfy an additional combinatorial property called inclusiveness form a…

Information Theory · Computer Science 2026-01-15 Yuto Mizunuma , Yuichiro Fujiwara

Modern biomedical research frequently involves testing multiple related hypotheses, while maintaining control over a suitable error rate. In many applications the false discovery rate (FDR), which is the expected proportion of false…

Methodology · Statistics 2018-09-27 David S. Robertson , James M. S. Wason

We consider a multiple hypothesis testing setting where the hypotheses are ordered and one is only permitted to reject an initial contiguous block, H_1,\dots,H_k, of hypotheses. A rejection rule in this setting amounts to a procedure for…

Statistics Theory · Mathematics 2015-03-25 Max Grazier G'Sell , Stefan Wager , Alexandra Chouldechova , Robert Tibshirani

When testing a number of statistical hypotheses using data from location families, it is often useful to control the false discovery rate (FDR) not just for hypotheses of the null values but also of other parameter values that are deemed…

Methodology · Statistics 2026-05-12 Zijun Gao , Wenjie Hu , Qingyuan Zhao

This paper studies the adversarial robustness of conformal novelty detection. In particular, we focus on two powerful learning-based frameworks that come with finite-sample false discovery rate (FDR) control: one is AdaDetect (by Marandon…

Machine Learning · Statistics 2026-04-03 Daofu Zhang , Mehrdad Pournaderi , Hanne M. Clifford , Yu Xiang , Pramod K. Varshney

We present false discovery rate smoothing, an empirical-Bayes method for exploiting spatial structure in large multiple-testing problems. FDR smoothing automatically finds spatially localized regions of significant test statistics. It then…

Methodology · Statistics 2016-11-15 Wesley Tansey , Oluwasanmi Koyejo , Russell A. Poldrack , James G. Scott

This paper studies the distributed conditional feature screening for massive data with ultrahigh-dimensional features. Specifically, three distributed partial correlation feature screening methods (SAPS, ACPS and JDPS methods) are firstly…

Methodology · Statistics 2024-03-12 Naiwen Pang , Xiaochao Xia

When multiple hypotheses are tested, interest is often in ensuring that the proportion of false discoveries (FDP) is small with high confidence. In this paper, confidence upper bounds for the FDP are constructed, which are simultaneous over…

Methodology · Statistics 2020-01-07 Jesse Hemerik , Aldo Solari , Jelle J. Goeman

The local false discovery rate (lfdr) of Efron et al. (2001) enjoys major conceptual and decision-theoretic advantages over the false discovery rate (FDR) as an error criterion in multiple testing, but is only well-defined in Bayesian…

Statistics Theory · Mathematics 2025-02-25 Daniel Xiang , Jake A. Soloff , William Fithian