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Background:Typically, proteins perform key biological functions by interacting with each other. As a consequence, predicting which protein pairs interact is a fundamental problem. Experimental methods are slow, expensive, and may be error…

Biomolecules · Quantitative Biology 2022-02-08 Leonardo Martini , Adriano Fazzone , Luca Becchetti

The inductive biases of trained neural networks are difficult to understand and, consequently, to adapt to new settings. We study the inductive biases of linearizations of neural networks, which we show to be surprisingly good summaries of…

Machine Learning · Statistics 2021-04-29 Wesley J. Maddox , Shuai Tang , Pablo Garcia Moreno , Andrew Gordon Wilson , Andreas Damianou

The upcoming landscape of Earth Observation missions will defined by networked heterogeneous nanosatellite constellations required to meet strict mission requirements, such as revisit times and spatial resolution. However, scheduling…

Signal Processing · Electrical Eng. & Systems 2024-03-05 Guillem Casadesus-Vila , Joan-Adria Ruiz-de-Azua , Eduard Alarcon

Protein (receptor)--ligand interaction prediction is a critical component in computer-aided drug design, significantly influencing molecular docking and virtual screening processes. Despite the development of numerous scoring functions in…

Biomolecules · Quantitative Biology 2024-01-22 Haoyu Lin , Shiwei Wang , Jintao Zhu , Yibo Li , Jianfeng Pei , Luhua Lai

In social networks, neighborhood is crucial for understanding individual behavior in response to environments, and thus it is essential to analyze an individual's local perspective within the global network. This paper studies how to…

Methodology · Statistics 2025-02-25 Lijia Wang , Xiao Han , Yanhui Wu , Y. X. Rachel Wang

Inference of the network structure (e.g., routing topology) and dynamics (e.g., link performance) is an essential component in many network design and management tasks. In this paper we propose a new, general framework for analyzing and…

Networking and Internet Architecture · Computer Science 2019-11-13 Jian Ni , Sekhar Tatikonda

Comparative graph and network analysis play an important role in both systems biology and pattern recognition, but existing surveys on the topic have historically ignored or underserved one or the other of these fields. We present an…

Social and Information Networks · Computer Science 2019-05-17 Emily Evans , Marissa Graham

Network alignment aims to find regions of topological or functional similarities between networks. In computational biology, it can be used to transfer biological knowledge from a well-studied species to a poorly-studied species between…

Molecular Networks · Quantitative Biology 2014-10-21 Joseph Crawford , Tijana Milenković

Social network alignment, aligning different social networks on their common users, is receiving dramatic attention from both academic and industry. All existing studies consider the social network to be static and neglect its inherent…

Social and Information Networks · Computer Science 2019-11-04 Li Sun , Zhongbao Zhang , Pengxin Ji , Jian Wen , Sen Su , Philip S. Yu

Foundation models have impressive performance and generalization capabilities across a wide range of applications. The increasing size of the models introduces great challenges for the training. Tensor parallelism is a critical technique…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-23 Shenggan Cheng , Ziming Liu , Jiangsu Du , Yang You

Detecting dynamic patterns of task-specific responses shared across heterogeneous datasets is an essential and challenging problem in many scientific applications in medical science and neuroscience. In our motivating example of rodent…

Neurons and Cognition · Quantitative Biology 2024-07-02 Yubai Yuan , Babak Shahbaba , Norbert Fortin , Keiland Cooper , Qing Nie , Annie Qu

This paper introduces a novel computational approach for offloading sensor data processing tasks to servers in edge networks for better accuracy and makespan. A task is assigned with one of several offloading options, each comprises a…

Networking and Internet Architecture · Computer Science 2025-05-05 Negar Erfaniantaghvayi , Zhongyuan Zhao , Kevin Chan , Ananthram Swami , Santiago Segarra

In this paper we describe SYNERGY, which is a highly parallelizable, linear planning system that is based on the genetic programming paradigm. Rather than reasoning about the world it is planning for, SYNERGY uses artificial selection,…

Artificial Intelligence · Computer Science 2007-05-23 Ion Muslea

Detecting the interactions of genetic compounds like genes, SNPs, proteins, metabolites, etc. can potentially unravel the mechanisms behind complex traits and common genetic disorders. Several methods have been taken into consideration for…

Computational Engineering, Finance, and Science · Computer Science 2015-05-26 Francesco Gadaleta

Self-organizing complex systems typically are comprised of a large number of frequently similar components or events. Through their process, a pattern at the global-level of a system emerges solely from numerous interactions among the…

Artificial Intelligence · Computer Science 2007-05-23 Vitorino Ramos , Ajith Abraham

Low-rank and sparse composite approximation is a natural idea to compress Large Language Models (LLMs). However, such an idea faces two primary challenges that adversely affect the performance of existing methods. The first challenge…

Machine Learning · Computer Science 2026-02-27 Changhai Zhou , Qian Qiao , Yuhua Zhou , Yuxin Wu , Shichao Weng , Weizhong Zhang , Cheng Jin

Protein-protein interaction (PPI) network alignment is a canonical operation to transfer biological knowledge among species. The alignment of PPI-networks has many applications, such as the prediction of protein function, detection of…

Molecular Networks · Quantitative Biology 2019-05-15 Ehsan Kazemi , Matthias Grossglauser

The need for fast sparse optimization is emerging, e.g., to deal with large-dimensional data-driven problems and to track time-varying systems. In the framework of linear sparse optimization, the iterative shrinkage-thresholding algorithm…

Optimization and Control · Mathematics 2025-01-22 Vito Cerone , Sophie M. Fosson , Diego Regruto

This paper proposes a novel approach to solving nonlinear programming problems using a sharp augmented Lagrangian method with a smoothing technique. Traditional sharp augmented Lagrangian methods are known for their effectiveness but are…

Optimization and Control · Mathematics 2024-10-07 José Luis Romero , Damián Fernandez , Germán Ariel Torres

In this paper, we propose a quasi-Newton method for solving smooth and monotone nonlinear equations, including unconstrained minimization and minimax optimization as special cases. For the strongly monotone setting, we establish two global…

Optimization and Control · Mathematics 2024-10-04 Ruichen Jiang , Aryan Mokhtari