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One of the most difficult problems difficult problem in systems biology is to discover protein-protein interactions as well as their associated functions. The analysis and alignment of protein-protein interaction networks (PPIN), which are…

Molecular Networks · Quantitative Biology 2019-02-20 Ricardo Alberich , Adrià Alcala , Mercè Llabrés , Francesc Rosselló , Gabriel Valiente

The relationship between the design and functionality of molecular networks is now a key issue in biology. Comparison of regulatory networks performing similar tasks can give insights into how network architecture is constrained by the…

Molecular Networks · Quantitative Biology 2015-06-26 Ala Trusina , Kim Sneppen , Ian B. Dodd , Keith E. Shearwin , J. Barry Egan

Many problems in modern robotics can be addressed by modeling them as bilevel optimization problems. In this work, we leverage augmented Lagrangian methods and recent advances in automatic differentiation to develop a general-purpose…

Robotics · Computer Science 2019-07-03 Benoit Landry , Zachary Manchester , Marco Pavone

Biological network alignment aims to identify similar regions between networks of different species. Existing methods compute node "similarities" to rapidly identify from possible alignments the "high-scoring" alignments with respect to the…

Molecular Networks · Quantitative Biology 2013-11-12 Vikram Saraph , Tijana Milenković

This paper proposes a novel distributed semismooth Newton based augmented Lagrangian method for solving a class of optimization problems over networks, where the global objective is defined as the sum of locally held cost functions, and…

Optimization and Control · Mathematics 2026-03-02 Qihao Ma , Chengjing Wang , Peipei Tang , Dunbiao Niu , Aimin Xu

This article proposes a novel Bayesian classification framework for networks with labeled nodes. While literature on statistical modeling of network data typically involves analysis of a single network, the recent emergence of complex data…

Methodology · Statistics 2020-09-25 Sharmistha Guha , Abel Rodriguez

Network alignment (NA) is the task of finding the correspondence of nodes between two networks based on the network structure and node attributes. Our study is motivated by the fact that, since most of existing NA methods have attempted to…

Social and Information Networks · Computer Science 2023-08-21 Jin-Duk Park , Cong Tran , Won-Yong Shin , Xin Cao

This study addresses the challenge of predicting network dynamics, such as forecasting disease spread in social networks or estimating species populations in predator-prey networks. Accurate predictions in large networks are difficult due…

Social and Information Networks · Computer Science 2023-08-23 Rui Luo

A fundamental component of neural network verification is the computation of bounds on the values their outputs can take. Previous methods have either used off-the-shelf solvers, discarding the problem structure, or relaxed the problem even…

Network alignment generalizes and unifies several approaches for forming a matching or alignment between the vertices of two graphs. We study a mathematical programming framework for network alignment problem and a sparse variation of it…

Optimization and Control · Mathematics 2011-11-03 Mohsen Bayati , David F. Gleich , Amin Saberi , Ying Wang

This paper addresses an optimization problem in satellite observation mission planning, focusing on the challenges of decentralized decision-making among satellites, which is crucial for optimizing strategies in dynamic observation…

Optimization and Control · Mathematics 2024-09-13 Vincenzo Basco

We propose a general framework to extract microscopic interactions from raw configurations with deep neural networks. The approach replaces the modeling Hamiltonian by the neural networks, in which the interaction is encoded. It can be…

Computational Physics · Physics 2020-08-19 Lingxiao Wang , Yin Jiang , Kai Zhou

Quantifying the relations (e.g., similarity) between complex networks paves the way for studying the latent information shared across networks. However, fundamental relation metrics are not well-defined between networks. As a compromise,…

Social and Information Networks · Computer Science 2023-07-21 Yang Tian , Hedong Hou , Guangzheng Xu , Ziyang Zhang , Pei Sun

The Knapsack Problem is a classic problem in combinatorial optimisation. Solving these problems may be computationally expensive. Recent years have seen a growing interest in the use of deep learning methods to approximate the solutions to…

Machine Learning · Computer Science 2023-12-07 Mitchell Keegan , Mahdi Abolghasemi

We consider Lagrangian duality based approaches to design and analyze algorithms for online energy-efficient scheduling. First, we present a primal-dual framework. Our approach makes use of the Lagrangian weak duality and convexity to…

Data Structures and Algorithms · Computer Science 2014-08-06 Nguyen Kim Thang

Graph embedding has been widely applied in areas such as network analysis, social network mining, recommendation systems, and bioinformatics. However, current graph construction methods often require the prior definition of neighborhood…

Machine Learning · Computer Science 2025-10-08 S. Peng , L. Hu , W. Zhang , B. Jie , Y. Luo

The Augmented Lagrangian Alternating Direction Inexact Newton (ALADIN) method is a cutting-edge distributed optimization algorithm known for its superior numerical performance. It relies on each agent transmitting information to a central…

Systems and Control · Electrical Eng. & Systems 2025-04-09 Xu Du , Xiaohua Zhou , Shijie Zhu

Integrating data from heterogeneous sources is often modeled as merging graphs. Given two or more 'compatible', but not-isomorphic graphs, the first step is to identify a graph alignment, where a potentially partial mapping of vertices…

Social and Information Networks · Computer Science 2018-03-13 Abdurrahman Yaşar , Ümit V. Çatalyürek

Empirical studies of graphs have contributed enormously to our understanding of complex systems. Known today as network science, what was originally a theoretical study of graphs has grown into a more scientific exploration of communities…

Quantitative Methods · Quantitative Biology 2020-01-01 Ryan E. Langendorf , Debra S. Goldberg

Biological network alignment (NA) aims to identify similar regions between molecular networks of different species. NA can be local or global. Just as the recent trend in the NA field, we also focus on global NA, which can be pairwise (PNA)…

Molecular Networks · Quantitative Biology 2020-04-28 Vipin Vijayan , Shawn Gu , Eric Krebs , Lei Meng , Tijana Milenkovic