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Coherence analysis plays a vital role in the study of functional brain connectivity. However, coherence captures only linear spectral associations, and thus can produce misleading findings when ignoring variations of connectivity in the…

Epilepsy is one of the most common neurological diseases, characterized by transient and unprovoked events called epileptic seizures. Electroencephalogram (EEG) is an auxiliary method used to perform both the diagnosis and the monitoring of…

A novel framework is proposed for handling the complex task of modelling and analysis of longitudinal, multivariate, heterogeneous clinical data. This method uses temporal abstraction to convert the data into a more appropriate form for…

Machine Learning · Computer Science 2025-05-09 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Empirical likelihood approach is one of non-parametric statistical methods, which is applied to the hypothesis testing or construction of confidence regions for pivotal unknown quantities. This method has been applied to the case of…

Statistics Theory · Mathematics 2015-09-21 Fumiya Akashi , Yan Liu , Masanobu Taniguchi

The prospect of future treatment warrants the development of cost-effective screening for Alzheimer's disease (AD). A promising candidate in this regard is electroencephalography (EEG), as it is one of the most economic imaging modalities.…

Signal Processing · Electrical Eng. & Systems 2024-05-01 Stephan Goerttler , Fei He , Min Wu

Discriminating patients with Alzheimer's disease (AD) from healthy subjects is a crucial task in the research of Alzheimer's disease. The task can be potentially achieved by linear discriminant analysis (LDA), which is one of the most…

Methodology · Statistics 2020-05-05 Yingjie Li , Liangliang Zhang , Tapabrata Maiti

Large-scale models pre-trained on Electroencephalography (EEG) have shown promise in clinical applications such as neurological disorder detection. However, the practical deployment of EEG-based large-scale models faces critical challenges…

Machine Learning · Computer Science 2025-08-12 Guanghao Jin , Yuan Liang , Yihan Ma , Jingpei Wu , Guoyang Liu

This paper formulates a penalized empirical likelihood (PEL) method for inference on the population mean when the dimension of the observations may grow faster than the sample size. Asymptotic distributions of the PEL ratio statistic is…

Statistics Theory · Mathematics 2013-02-28 Soumendra N. Lahiri , Subhodeep Mukhopadhyay

Applications of structural equation models (SEMs) are often restricted to linear associations between variables. Maximum likelihood (ML) estimation in non-linear models may be complex and require numerical integration. Furthermore, ML…

Methodology · Statistics 2019-03-15 Klaus Kähler Holst , Esben Budtz-Jørgensen

In this paper we investigate the use of staged tree models for discrete longitudinal data. Staged trees are a type of probabilistic graphical model for finite sample space processes. They are a natural fit for longitudinal data because a…

Methodology · Statistics 2024-01-10 Jack Storror Carter , Manuele Leonelli , Eva Riccomagno , Alessandro Ugolini

Machine learning analysis of longitudinal neuroimaging data is typically based on supervised learning, which requires a large number of ground-truth labels to be informative. As ground-truth labels are often missing or expensive to obtain…

Machine Learning · Computer Science 2021-06-29 Qingyu Zhao , Zixuan Liu , Ehsan Adeli , Kilian M. Pohl

The spatial correlations and the temporal contexts are indispensable in Electroencephalogram (EEG)-based emotion recognition. However, the learning of complex spatial correlations among several channels is a challenging problem. Besides,…

Signal Processing · Electrical Eng. & Systems 2022-11-23 Yiheng Tang , Yongxiong Wang , Xiaoli Zhang , Zhe Wang

We consider the estimation of large covariance and precision matrices from high-dimensional sub-Gaussian or heavier-tailed observations with slowly decaying temporal dependence. The temporal dependence is allowed to be long-range so with…

Statistics Theory · Mathematics 2019-12-23 Hai Shu , Bin Nan

Collecting multiple longitudinal measurements and time-to-event outcomes is a common practice in clinical and epidemiological studies, often focusing on exploring associations between them. Joint modeling is the standard analytical tool for…

Methodology · Statistics 2024-12-10 Taban Baghfalaki , Reza Hashemi , Catherine Helmer , Helene Jacqmin-Gadda

The key to successful statistical analysis of bivariate extreme events lies in flexible modelling of the tail dependence relationship between the two variables. In the extreme value theory literature, various techniques are available to…

Methodology · Statistics 2025-05-05 Emma S. Simpson , Jonathan A. Tawn

Schizophrenia is a complex psychiatric disorder involving changes in thought patterns, perception, mood, and behavior. The diagnosis of schizophrenia is challenging and requires that patients show two or more positive symptoms for at least…

Machine Learning · Computer Science 2021-02-17 Maritza Tynes , Mahboobeh Parsapoor

Objective: Post-traumatic epilepsy (PTE) is a debilitating neurological disorder that develops after traumatic brain injury (TBI). Early prediction of PTE remains challenging due to heterogeneous clinical data, limited positive cases, and…

Machine Learning · Computer Science 2026-04-17 Wenhui Cui , Nicholas Swingle , Anand A. Joshi , Dileep Nair , Richard M. Leahy

In an increasing number of neuroimaging studies, brain images, which are in the form of multidimensional arrays (tensors), have been collected on multiple subjects at multiple time points. Of scientific interest is to analyze such massive…

Long-term causal inference has drawn increasing attention in many scientific domains. Existing methods mainly focus on estimating average long-term causal effects by combining long-term observational data and short-term experimental data.…

Machine Learning · Computer Science 2025-03-04 Weilin Chen , Ruichu Cai , Junjie Wan , Zeqin Yang , José Miguel Hernández-Lobato

Recent self-supervised advances in medical computer vision exploit global and local anatomical self-similarity for pretraining prior to downstream tasks such as segmentation. However, current methods assume i.i.d. image acquisition, which…

Computer Vision and Pattern Recognition · Computer Science 2023-12-13 Mengwei Ren , Neel Dey , Martin A. Styner , Kelly Botteron , Guido Gerig