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Cells perform directed motion in response to external stimuli that they detect by sensing the environment with their membrane protrusions. In particular, several biochemical and biophysical cues give rise to tactic migration in the…

Cell Behavior · Quantitative Biology 2020-07-15 N. Loy , M. Conte

Chemotaxis, the directional locomotion of cells towards a source of a chemical gradient, is an integral part of many biological processes - for example, bacteria motion, single-cell or multicellular organisms development, immune response,…

Analysis of PDEs · Mathematics 2021-03-29 Yishu Gong , Alexander Kiselev

Enhancing robot navigation efficiency is a crucial objective in modern robotics. Robots relying on external navigation systems are often susceptible to electromagnetic interference (EMI) and encounter environmental disturbances, resulting…

Robotics · Computer Science 2024-04-03 Saleem Alzoubi , Mahdi H. Miraz

The ability to navigate in complex, inhomogeneous environments is fundamental to survival at all length scales, giving rise to the rapid development of various subfields in bio-locomotion such as the well established concept of chemotaxis.…

Soft Condensed Matter · Physics 2020-05-06 Yuanjian Zheng , Hartmut Löwen

Inspired by the chemotaxis interaction of living cells, we have developed an agent-based approach for self-organizing shape formation. Since all our simulations begin with a different uniform random configuration and our agents move…

Multiagent Systems · Computer Science 2018-03-13 Sean Grimes , Linge Bai , Andrew W. E. McDonald , David E. Breen

Learning to navigate in complex environments with dynamic elements is an important milestone in developing AI agents. In this work we formulate the navigation question as a reinforcement learning problem and show that data efficiency and…

Directed cell motion in response to an external chemical gradient occurs in many biological phenomena such as wound healing, angiogenesis, and cancer metastasis. Chemotaxis is often characterized by the accuracy, persistence, and speed of…

Cell Behavior · Quantitative Biology 2019-06-19 Julien Varennes , Hye-ran Moon , Soutick Saha , Andrew Mugler , Bumsoo Han

Cell migration is fundamental to development, tissue organization, immune response, and disease progression. Amoeboid motility is distinguished by rapid motion and strongly fluctuating cell shapes, reflecting the intrinsically nonlinear…

Soft Condensed Matter · Physics 2026-05-19 Winfried Schmidt , Chaouqi Misbah , Alexander Farutin

Navigation is a complex skill with a long history of research in animals and humans. In this work, we simulate the Morris Water Maze in 2D to train deep reinforcement learning agents. We perform automatic classification of navigation…

Machine Learning · Computer Science 2023-11-09 Andrew Liu , Alla Borisyuk

Aerotaxis is the particular form of chemotaxis in which oxygen plays the role of both the attractant and the repellent. Aerotaxis occurs without methylation adaptation, and it leads to fast and complete aggregation toward the most favorable…

Classical Analysis and ODEs · Mathematics 2015-06-26 Barbara "Bori" C. Mazzag

Active matter systems comprise self-propelled particles that move on a substrate while leaving chemical trails that influence other particles through chemotaxis (e.g., slime-depositing bacteria). Orientational chemotaxis manifests as a…

Soft Condensed Matter · Physics 2025-12-11 Aymeric Lutier , Frédéric van Wijland , Jean-Baptiste Fournier

Chemotaxis combines three processes: directional sensing, polarity reorientation and migration. Directed migration plays an important role in immune response, metastasis, wound healing and development. To describe chemotaxis, we extend a…

Biological Physics · Physics 2023-12-04 Pedro C. Dal-Castel , Gilberto L. Thomas , Gabriel C. Perrone , Rita M. C. de Almeida

This paper presents a novel robot-environment interaction in navigation tasks such that robots have neither a representation of their working space nor planning function, instead, an active environment takes charge of these aspects. This is…

Robotics · Computer Science 2022-02-15 Shota Kameyama , Keisuke Okumura , Yasumasa Tamura , Xavier Défago

In eukaryotic cell chemotaxis, cells extend and retract transient actin-driven protrusions at their membrane that facilitate both the detection of external chemical gradients and directional movement via the formation of focal adhesions…

Cell Behavior · Quantitative Biology 2025-09-25 Samuel W. S. Johnson , Maddy Parsons , Ruth E. Baker , Philip K. Maini

Autologous chemotaxis, in which cells secrete and detect molecules to determine the direction of fluid flow, is thwarted at high cell density because molecules from other cells interfere with a given cell's signal. Using a minimal model of…

Biological Physics · Physics 2022-09-14 Michael Vennettilli , Louis Gonzalez , Nicholas Hilgert , Andrew Mugler

In chemotaxis, cells are modulating their migration patterns in response to concentration gradients of a guiding substance. Immune cells are believed to use such chemotactic sensing for remotely detecting and homing in on pathogens.…

Cell Behavior · Quantitative Biology 2019-02-28 Claus Metzner

Chemotaxis is typically modeled in the context of cellular motion towards a static, exogenous source of chemoattractant. Here, we propose a time-dependent mechanism of chemotaxis in which a self-propelled particle ({\it e.g.}, a cell)…

Cell Behavior · Quantitative Biology 2026-05-12 Sarah A. Nowak , Buddhapriya Chakrabarti , Tom Chou , Ajay Gopinathan

Hybrid models of chemotaxis combine agent-based models of cells with partial differential equation models of extracellular chemical signals. In this paper, travelling wave properties of hybrid models of bacterial chemotaxis are…

Biological Physics · Physics 2013-02-13 Benjamin Franz , Chuan Xue , Kevin J. Painter , Radek Erban

A wide array of biological systems can navigate in shallow gradients of chemoattractant with remarkable precision. Whilst previous approaches model such systems using coarse-grained chemical density profiles, we construct a dynamical model…

Biological Physics · Physics 2023-12-19 Jacob Knight , Paula García-Galindo , Johannes Pausch , Gunnar Pruessner

A simple model is proposed that describes the various morphodynamic principles of migrating cells from polar to amoeboidal motions. The model equation is derived using competing internal cellular compass variables and symmetries of the…

Cell Behavior · Quantitative Biology 2013-01-30 Shuji Ishihara