Related papers: Detecting single viruses and nanoparticles using w…
The author discusses the laser interference method to measure the size of small bio-particles: extracellular vesicles (EVs), exosomes and viruses of nanometer scale in flow cytometry. By introducing a new laser configuration in place of…
We study the behavior of charged spherical Au nanoparticles in a nanofluidic slit as a function of the separation of the symmetrically charged confining surfaces. A dedicated setup called the nano-fluidic confinement apparatus (NCA) allows…
We propose the use of wavelength-dependent spectroscopic absorption in the evanescent field of ultra-compact whispering gallery mode microspherical lasers as selective gas sensors and estimate few ppm detection sensitivity using a simple…
Scatterer induced modal coupling and the consequent mode splitting in a whispering gallery mode resonator is demonstrated in aqueous environment. The rate of change in splitting as particles enter the resonator mode volume strongly depends…
Structural studies of biological macromolecules are severely limited by radiation damage. Traditional crystallography curbs the effects of damage by spreading damage over many copies of the molecule of interest. X-ray lasers, such as the…
Recently, imaging by microspheres and dielectric particle-lenses emerged as a simple solution to obtaining super-resolution images of nanoscale devices and structures. Calibrated resolution of ~{\lambda}/6 - {\lambda}/8 has been…
Interactions between whispering gallery modes (WGMs) and small nanoparticles are commonly modelled by treating the particle as a point dipole scatterer. This approach is assumed to be accurate as long as the nanoparticle radius, $a$, is…
Visible and infrared photons can be detected with a broadband response via the internal photoeffect. By using plasmonic nanostructures, i.e. nanoantennas, wavelength selectivity can be introduced to such detectors through geometry-dependent…
Accurately measuring the size, morphology, and structure of nanoparticles is very important, because they are strongly dependent on their properties for many applications. In this paper, we present a deep-learning based method for…
Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…
The photothermal heterodyne imaging technique enabled studies of individual weakly absorbing nano-objects in various environments. It uses a photo-induced change in the refractive index of the environment. Taking advantage of the dramatic…
Whispering-gallery mode (WGM) resonators combine small optical mode volumes with narrow resonance linewidths, making them exciting platforms for a variety of applications. Here we report a flying WGM microlaser, realized by optically…
Nanoparticles, exhibiting functionally relevant structural heterogeneity, are at the forefront of cutting-edge research. Now, high-throughput single-particle imaging (SPI) with x-ray free-electron lasers (XFELs) creates unprecedented…
Spectroscopy of whispering-gallery mode (WGM) microresonators has become a powerful scientific tool, enabling detection of single viruses, nanoparticles, and even single molecules. Yet the demonstrated timescale of these schemes has been…
The application of precision interferometers is generally restricted to expensive and smooth high-quality surfaces. Here, we offer a route to ultimate miniaturization of interferometer by integrating beam splitter, reference mirror and…
Precise localization of nanoparticles within a cell is crucial to the understanding of cell-particle interactions and has broad applications in nanomedicine. Here, we report a proof-of-principle experiment for imaging individual…
The physical and electronic properties of ultrathin two-dimensional (2D) layered nanomaterials are highly related to their thickness. Therefore, the rapid and accurate identification of single- and few- to multi-layer nanosheets is…
Nano-size objects like metal clusters present an ideal system for the study of quantum phenomena and for constructing practical quantum devices. Integrating these small objects in a macroscopic circuit is, however, a difficult task. So far…
Super-resolution imaging using sub-diffraction field localization by micron sized transparent beads (microspheres) was recently demonstrated [1]. Practical applications in microscopy require control over the positioning of the microspheres.…
Free-electron laser hard X-ray light sources can provide high fluence, femtosecond pulses, enabling the time-resolved probing of structural dynamics and elementary relaxation processes in molecules. Traditional X-ray elastic scattering from…