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Surface molecules, distributed in diverse patterns and clusters on cell membranes, influence vital functions of living cells. It is therefore important to understand their molecular surface organisation under different physiological and…

Interactive visualization of embedding projections is a useful technique for understanding data and evaluating machine learning models. Labeling data within these visualizations is critical for interpretation, as labels provide an overview…

Human-Computer Interaction · Computer Science 2025-05-20 Donghao Ren , Fred Hohman , Dominik Moritz

Image clustering is an important and open-challenging task in computer vision. Although many methods have been proposed to solve the image clustering task, they only explore images and uncover clusters according to the image features, thus…

Computer Vision and Pattern Recognition · Computer Science 2023-04-11 Shaotian Cai , Liping Qiu , Xiaojun Chen , Qin Zhang , Longteng Chen

Object counting and localization are key steps for quantitative analysis in large-scale microscopy applications. This procedure becomes challenging when target objects are overlapping, are densely clustered, and/or present fuzzy boundaries.…

Computer Vision and Pattern Recognition · Computer Science 2022-03-30 Shijie Li , Thomas Ach , Guido Gerig

While clustering is ubiquitously used across science and industry, uncertainty in cluster assignments is rarely quantified with rigorous guarantees. We propose a novel conformal inference framework for clustering that returns confidence…

Methodology · Statistics 2026-04-13 YoonHaeng Hur , Anirban Nath , Genevera Allen

Locating the center of convex objects is important in both image processing and unsupervised machine learning/data clustering fields. The automated analysis of biological images uses both of these fields for locating cell nuclei and for…

Computer Vision and Pattern Recognition · Computer Science 2018-04-12 James Kapaldo , Xu Han , Domingo Mery

Clustering of hyperspectral images is a fundamental but challenging task. The recent development of hyperspectral image clustering has evolved from shallow models to deep and achieved promising results in many benchmark datasets. However,…

Computer Vision and Pattern Recognition · Computer Science 2021-11-16 Yaoming Cai , Zijia Zhang , Yan Liu , Pedram Ghamisi , Kun Li , Xiaobo Liu , Zhihua Cai

Image clustering is a particularly challenging computer vision task, which aims to generate annotations without human supervision. Recent advances focus on the use of self-supervised learning strategies in image clustering, by first…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Foivos Ntelemis , Yaochu Jin , Spencer A. Thomas

In biological and medical research, scientists now routinely acquire microscopy images of hundreds of morphologically heterogeneous organoids and are then faced with the task of finding patterns in the image collection, i.e., subsets of…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Jannik Presberger , Rashmiparvathi Keshara , David Stein , Yung Hae Kim , Anne Grapin-Botton , Bjoern Andres

Colocalization aims at characterizing spatial associations between two fluorescently-tagged biomolecules by quantifying the co-occurrence and correlation between the two channels acquired in fluorescence microscopy. Colocalization is…

Applications · Statistics 2019-07-12 Frédéric Lavancier , Thierry Pécot , Liu Zengzhen , Charles Kervrann

We describe a new optimization scheme for finding high-quality correlation clusterings in planar graphs that uses weighted perfect matching as a subroutine. Our method provides lower-bounds on the energy of the optimal correlation…

Computer Vision and Pattern Recognition · Computer Science 2012-08-03 Julian Yarkony , Alexander T. Ihler , Charless C. Fowlkes

When a single molecule is detected in a wide-field microscope, the image approximates the point spread function of the system. However, as the distribution of molecules becomes denser and their images begin to coincide, existing solutions…

Optics · Physics 2013-09-02 Anthony Barsic , Ginni Grover , Rafael Piestun

In computer vision, a prevailing method for quantifying dataset bias is to train a model to distinguish between datasets. High classification accuracy is then interpreted as evidence of meaningful semantic differences. This approach assumes…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Amir Hossein Saleknia , Mohammad Sabokrou

Anomaly detection and localization in images is a growing field in computer vision. In this area, a seemingly understudied problem is anomaly clustering, i.e., identifying and grouping different types of anomalies in a fully unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Andrei-Timotei Ardelean , Tim Weyrich

Comparing clusterings is central to evaluating unsupervised models, yet the many existing similarity measures can produce widely divergent, sometimes contradictory, evaluations. Clustering similarity measures are typically organized into…

Machine Learning · Statistics 2025-11-06 Alexander J. Gates

Motivated by the problem of colocalization analysis in fluorescence microscopic imaging, we study in this paper structured detection of correlated regions between two random processes observed on a common domain. We argue that although…

Statistics Theory · Mathematics 2016-04-11 Shulei Wang , Jianqing Fan , Ginger Pocock , Ming Yuan

The lack of large labeled medical imaging datasets, along with significant inter-individual variability compared to clinically established disease classes, poses significant challenges in exploiting medical imaging information in a…

Computer Vision and Pattern Recognition · Computer Science 2022-09-27 Matteo Ferrante , Tommaso Boccato , Simeon Spasov , Andrea Duggento , Nicola Toschi

Correlation Clustering (CC) is a foundational problem in unsupervised learning that models binary similarity relations using labeled graphs. While classical CC has been widely studied, many real-world applications involve more nuanced…

Data Structures and Algorithms · Computer Science 2025-09-23 Chenglin Fan , Dahoon Lee , Euiwoong Lee

Local clustering aims to identify specific substructures within a large graph without any additional structural information of the graph. These substructures are typically small compared to the overall graph, enabling the problem to be…

Machine Learning · Computer Science 2025-10-31 Zhaiming Shen , Sung Ha Kang

Super-resolution microscopy has catalyzed valuable insights into the sub-cellular, mechanistic details of many different biological processes across a wide range of cell types. Fluorescence polarization spectroscopy tools have also enabled…

Biological Physics · Physics 2023-01-25 Jack W Shepherd , Alex L Payne-Dwyer , Ji-Eun Lee , Aisha Syeda , Mark C Leake