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In the last years, tens of thousands gene expression profiles for cells of several organisms have been monitored. Gene expression is a complex transcriptional process where mRNA molecules are translated into proteins, which control most of…
Markov State Models (MSM) are widely used to elucidate dynamic properties of molecular systems from unbiased Molecular Dynamics (MD). However, the implementation of reweighting schemes for MSMs to analyze biased simulations, for example…
A flood of reliable seismic data will soon arrive. The migration to larger telescopes on the ground may free up 4-m class instruments for multi-site campaigns, and several forthcoming satellite missions promise to yield nearly uninterrupted…
We develop a model-based methodology for integrating gene-set information with an experimentally-derived gene list. The methodology uses a previously reported sampling model, but takes advantage of natural constraints in the…
The imaging community has increasingly adopted machine learning (ML) methods to provide individualized imaging signatures related to disease diagnosis, prognosis, and response to treatment. Clinical neuroscience and cancer imaging have been…
Diabetes is a serious chronic metabolic disease. In the recent years, more and more consumer technology enterprises focusing on human health are committed to implementing accurate and non-invasive blood glucose algorithm in their products.…
Modern scientific studies often require the identification of a subset of relevant explanatory variables, in the attempt to understand an interesting phenomenon. Several statistical methods have been developed to automate this task, but…
Statistical machine learning often uses probabilistic algorithms, such as Markov Chain Monte Carlo (MCMC), to solve a wide range of problems. Many accelerators are proposed using specialized hardware to address sampling inefficiency, the…
Causal mediation analysis, pleiotropy analysis, and replication analysis are three highly popular genetic study designs. Although these analyses address different scientific questions, the underlying inference problems all involve…
The widespread use of generalized linear models in case-control genetic studies has helped identify many disease-associated risk factors typically defined as DNA variants, or single nucleotide polymorphisms (SNPs). Up to now, most…
The detection of cardiovascular diseases (CVD) using machine learning techniques represents a significant advancement in medical diagnostics, aiming to enhance early detection, accuracy, and efficiency. This study explores a comparative…
We study a diagnostic strategy which is based on the anticipation of the diagnostic process by simulation of the dynamical process starting from the initial findings. We show that such a strategy could result in more accurate diagnoses…
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with human traits or diseases in the past decade. Nevertheless, much of the heritability of many traits is still unaccounted for. Commonly used…
The combination of big data and deep learning is a world-shattering technology that can greatly impact any objective if used properly. With the availability of a large volume of health care datasets and progressions in deep learning…
Missing genotypes can affect the efficacy of machine learning approaches to identify the risk genetic variants of common diseases and traits. The problem occurs when genotypic data are collected from different experiments with different DNA…
DNA microarrays are a relatively new technology that can simultaneously measure the expression level of thousands of genes. They have become an important tool for a wide variety of biological experiments. One of the most common goals of DNA…
Introduction: Feature selection and gene set analysis are of increasing interest in bioinformatics. While these two approaches have been developed for different purposes, we describe how some gene set analysis methods can be used to conduct…
The COVID-19 pandemic has significantly increased the incidence of post-infection cardiovascular events, particularly myocardial infarction, in individuals over 40. While the underlying mechanisms remain elusive, this study employs a hybrid…
Standard logistic regression analysis of case-control data has low power to detect gene-environment interactions, but until recently it was the only method that could be used on complex polygenic data for which parametric distributional…
Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. MR is being widely used in epidemiology and other related areas of population science. In…