Related papers: A validated model of serum anti-Mullerian hormone …
The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related…
The measurement of ovarian volume has been shown to be a useful indirect indicator of the ovarian reserve in women of reproductive age, in the diagnosis and management of a number of disorders of puberty and adult reproductive function, and…
Many sexually mature females suffer from premenstrual syndrome (PMS), but effective coping methods for PMS are limited due to the complexity of symptoms and unclear pathogenesis. Awareness has shown promise in alleviating PMS symptoms but…
Great apes, the other living members of our hominid family, become decrepit before the age of forty and rarely outlive their fertile years. In contrast, women - even in high mortality hunter-gatherer populations - usually remain healthy and…
Women are at increased risk of bone loss during the menopausal transition; in fact, nearly 50\% of women's lifetime bone loss occurs during this time. The longitudinal relationships between estradiol (E2) and follicle-stimulating hormone…
During each ovarian cycle, only a definite number of follicles ovulate, while the others undergo a degeneration process called atresia. We have designed a multi-scale mathematical model where ovulation and atresia result from a hormonal…
Objective: To examine the moderation effects of hormonal factors on the associations between vascular risk factors and white matter hyperintensities (WMH) in men and women, separately. Methods: WMH were automatically segmented and…
Objectives: To examine sex differences in the associations between vascular risk factors and 6-year changes in the volume of white matter hyperintensities (WMH), and between changes in WMH volumes and changes in cognitive performance, in a…
Globular clusters encode the hierarchical assembly history of the Milky Way and the physics of multiple stellar populations. Using homogeneous stellar parameters for 69 Galactic globular clusters derived while modelling multiple…
Background:Adverse reproductive history is a multisystemic risk factor, but evidence is constrained by isolated outcome studies, limited adjustment, and non-interpretable algorithmic models. We re-frame the estimand from prediction to…
Machine learning (ML) has shown great promise for revolutionizing a number of areas, including healthcare. However, it is also facing a reproducibility crisis, especially in medicine. ML models that are carefully constructed from and…
We investigated the possibility of producing helium enhanced stars in globular clusters by accreting polluted matter during the pre-main sequence phase. We followed the evolution of two different classes of pre-main sequence accreting…
Men and women differ in specific cognitive abilities and in the expression of several neuropsychiatric conditions. Such findings could be attributed to sex hormones, brain differences, as well as a number of environmental variables.…
Menopause fundamentally reshapes female physiology, yet current understanding is limited by small longitudinal cohorts that characterize it as a gradual transition. Large-scale biomedical datasets remain underutilized because the age of the…
Age-specific fertility rates (ASFRs) provide the most extensive record of reproductive change, but their aggregate nature obscures the individual-level behavioral mechanisms that drive fertility trends. To bridge this micro-macro divide, we…
Macroscopic, phenomenological models have proven useful as concise framings of our understandings in fields from statistical physics to economics to biology. Constructing a phenomenological model for development would provide a framework…
A source provides status updates to monitors through a network with state defined by a continuous-time finite Markov chain. An age of information (AoI) metric is used to characterize timeliness by the vector of ages tracked by the monitors.…
BACKGROUND: Atrial fibrillation (AF), the most common arrhythmia, is linked to high morbidity and mortality. In a fast-evolving AF rhythm control treatment era, predicting AF recurrence after its onset may be crucial to achieve the optimal…
The grandmother hypothesis is the most influential account of the evolution of menopause in humans, but other theories warrant investigation. Here I use simulations to investigate two theories that ground the evolution of menopause in…
Breast cancer incidence rises with age and peaks across the menopausal transition, yet why some postmenopausal lobules persist, and why that persistence predicts cancer risk, remains unresolved. Incomplete age-related lobular involution is…