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The production processes of proteins in prokaryotic cells are investigated. Most of the mathematical models in the literature study the production of {\em one} fixed type of proteins. When several classes of proteins are considered, an…

Quantitative Methods · Quantitative Biology 2014-11-07 Vincent Fromion , Emanuele Leoncini , Philippe Robert

In this article a generalized mathematical model describing the interactions between malignant tumour and immune system with discrete time delay incorporated into the system is considered. Time delay represents the time required to generate…

Tissues and Organs · Quantitative Biology 2015-11-05 Monika Joanna Piotrowska

Quasi steady state assumptions are often used to simplify complex systems of ordinary differential equations in modelling of biochemical processes. The simplified system is designed to have the same qualitative properties as the original…

Dynamical Systems · Mathematics 2013-12-11 Tomáš Vejchodský

In opinion dynamics, time delays in agent-to-agent interactions are ubiquitous, which can substantially disrupt the dynamical processes rooted in agents' opinion exchange, decision-making, and feedback mechanisms. However, a thorough…

Optimization and Control · Mathematics 2025-01-22 Lingling Yao , Aming Li

Many socio-economic and biological processes can be modeled as systems of interacting individuals. The behaviour of such systems can be often described within game-theoretic models. In these lecture notes, we introduce fundamental concepts…

Populations and Evolution · Quantitative Biology 2013-05-30 Jacek Miekisz

The theory of slow manifolds is an important tool in the study of deterministic dynamical systems, giving a practical method by which to reduce the number of relevant degrees of freedom in a model, thereby often resulting in a considerable…

Statistical Mechanics · Physics 2013-07-01 George W A Constable , Alan J McKane , Tim Rogers

In order to fulfill cell proliferation and differentiation through cellular hierarchy, stem cells can undergo either asymmetric or symmetric divisions. Recent studies pay special attention to the effect of different modes of stem cell…

Populations and Evolution · Quantitative Biology 2020-10-08 Zhijie Wu , Yuman Wang , Kun Wang , Da Zhou

Biochemical reaction networks are subjected to large fluctuations attributable to small molecule numbers, yet underlie reliable biological functions. Most theoretical approaches describe them as purely deterministic or stochastic dynamical…

Molecular Networks · Quantitative Biology 2013-06-11 Jingkui Wang , Marc Lefranc , Quentin Thommen

Real-world systems can be strongly influenced by time delays occurring in self-coupling interactions, due to unavoidable finite signal propagation velocities. When the delays become significantly long, complicated high-dimensional phenomena…

Chaotic Dynamics · Physics 2022-06-08 Serhiy Yanchuk , Giovanni Giacomelli

Modeling stochasticity in gene regulatory networks is an important and complex problem in molecular systems biology. To elucidate intrinsic noise, several modeling strategies such as the Gillespie algorithm have been used successfully. This…

Molecular Networks · Quantitative Biology 2013-01-18 David Murrugarra , Alan Veliz-Cuba , Boris Aguilar , Seda Arat , Reinhard Laubenbacher

At an unmanaged intersection, it is important to understand how much traffic delay may be caused as a result of microscopic vehicle interactions. Conventional traffic simulations that explicitly track these interactions are time-consuming.…

Multiagent Systems · Computer Science 2018-06-08 Changliu Liu , Mykel J. Kochenderfer

We study the stability of unstable steady states in scalar retarded time-delayed systems subjected to a variable-delay feedback control. The important aspect of such a control problem is that time-delayed systems are already…

Chaotic Dynamics · Physics 2010-07-08 Aleksandar Gjurchinovski , Viktor Urumov

The Poisson distribution is the probability distribution of the number of independent events in a given period of time. Although the Poisson distribution appears ubiquitously in various stochastic dynamics of gene expression, both as…

Statistical Mechanics · Physics 2024-10-02 Julian Lee

Delays are ubiquitous in modern hybrid systems, which exhibit both continuous and discrete dynamical behaviors. Induced by signal transmission, conversion, the nature of plants, and so on, delays may appear either in the continuous…

Systems and Control · Electrical Eng. & Systems 2021-03-23 Yunjun Bai , Ting Gan , Li Jiao , Bican Xia , Bai Xue , Naijun Zhan

Response delay is an inherent and essential part of human actions. In the context of human balance control, the response delay is traditionally modeled using the formalism of delay-differential equations, which adopts the approximation of…

Neurons and Cognition · Quantitative Biology 2018-08-22 Takashi Suzuki , Ihor Lubashevsky , Arkady Zgonnikov

Systems whose time evolutions are entirely deterministic can nevertheless be studied probabilistically, i.e. in terms of the evolution of probability distributions rather than individual trajectories. This approach is central to the…

Dynamical Systems · Mathematics 2019-09-06 S. Richard Taylor

Technologically driven transport systems are characterized by a networked structure connecting operation centers and by a dynamics ruled by pre-established schedules. Schedules impose serious constraints on the timing of the operations,…

Physics and Society · Physics 2013-01-30 Pablo Fleurquin , Jose J. Ramasco , Victor M. Eguiluz

This paper deals with partially-observed optimal control problems for the state governed by stochastic differential equation with delay. We develop a stochastic maximum principle for this kind of optimal control problems using a variational…

Optimization and Control · Mathematics 2020-10-15 Shuaiqi Zhang , Xun Li , Jie Xiong

Recently, a first step was made by the authors towards a systematic investigation of the effect of reaction-step-size noise - uncertainty in the step size of the reaction - on the dynamics of stochastic populations. This was done by…

Statistical Mechanics · Physics 2016-12-21 Shay Be'er , Michael Assaf

For cellular biochemical reaction systems where the numbers of molecules is small, significant noise is associated with chemical reaction events. This molecular noise can give rise to behavior that is very different from the predictions of…

Molecular Networks · Quantitative Biology 2009-11-13 Matthew Scott , Terence Hwa , Brian Ingalls