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We consider a realization of the XOR logic gate in a system involving two competing biocatalytic reactions, for which the logic-1 output is defined by these two processes causing a change in the optically detected signal. A model is…

Soft Condensed Matter · Physics 2010-11-09 Vladimir Privman , Jian Zhou , Jan Halamek , Evgeny Katz

We report the first systematic study of designed two-input biochemical systems as information processing gates with favorable noise-transmission properties accomplished by modifying the gate's response from convex shape to sigmoid in both…

Biological Physics · Physics 2013-11-05 Saira Bakshi , Oleksandr Zavalov , Jan Halamek , Vladimir Privman , Evgeny Katz

In this work we demonstrate both experimentally and theoretically that the analog noise generation by a single enzymatic logic gate can be dramatically reduced to yield gate operation with virtually no input noise amplification. This is…

Molecular Networks · Quantitative Biology 2010-10-12 Dmitriy Melnikov , Guinevere Strack , Marcos Pita , Vladimir Privman , Evgeny Katz

We review enzymatic systems which involve biocatalytic reactions utilized for information processing (biocomputing). Extensive ongoing research in biocomputing, mimicking Boolean logic gates has been motivated by potential applications in…

Biological Physics · Physics 2010-10-12 Evgeny Katz , Vladimir Privman

The first realization of a biomolecular OR gate function with double-sigmoid response (sigmoid in both inputs) is reported. Two chemical inputs activate the enzymatic gate processes resulting in the output signal: chromogen oxidation, which…

Molecular Networks · Quantitative Biology 2013-05-08 Oleksandr Zavalov , Vera Bocharova , Vladimir Privman , Evgeny Katz

Computing based on biochemical processes is a newest rapidly developing field of unconventional information and signal processing. In this paper we present results of our research in the field of biochemical computing and summarize the…

Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemical logic gates based on enzymatic reactions, and a network of…

Molecular Networks · Quantitative Biology 2010-09-22 Mary A. Arugula , Jan Halamek , Evgeny Katz , Dmitriy Melnikov , Marcos Pita , Vladimir Privman , Guinevere Strack

Biochemical computing is an emerging field of unconventional computing that attempts to process information with biomolecules and biological objects using digital logic. In this work we survey filtering in general, in biochemical computing,…

The first realization of a designed, rather than natural, biochemical filter process is reported and analyzed as a promising network component for increasing the complexity of biomolecular logic systems. Key challenge in biochemical logic…

Biological Physics · Physics 2010-11-09 Vladimir Privman , Jan Halamek , Mary A. Arugula , Dmitriy Melnikov , Vera Bocharova , Evgeny Katz

We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output allowing to make the gate's response sigmoid in both inputs. New functional forms are…

Soft Condensed Matter · Physics 2013-11-05 Vladimir Privman , Brian E. Fratto , Oleksandr Zavalov , Jan Halamek , Evgeny Katz

We propose a new experimentally corroborated paradigm in which the functionality of the brain's logic-gates depends on the history of their activity, e.g. an OR-gate that turns into a XOR-gate over time. Our results are based on an…

Neurons and Cognition · Quantitative Biology 2015-06-15 Roni Vardi , Shoshana Guberman , Amir Goldental , Ido Kanter

We demonstrate how a genetic ring oscillator network with quorum sensing feedback can operate as a robust logic gate. Specifically we show how a range of logic functions, namely AND/NAND, OR/NOR and XOR/XNOR, can be realized by the system,…

Biological Physics · Physics 2014-04-14 Vidit Agrawal , Shivpal Singh Kang , Sudeshna Sinha

Electrode-immobilized glucose-6-phosphate dehydrogenase is used to catalyze an enzymatic reaction which carries out the AND logic gate. This logic function is considered here in the context of biocatalytic processes utilized for the…

Molecular Networks · Quantitative Biology 2010-10-12 Vladimir Privman , Valber Pedrosa , Dmitriy Melnikov , Marcos Pita , Aleksandr Simonian , Evgeny Katz

Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logic inputs are performed. These two systems are examples of…

We develop an approach aimed at optimizing the parameters of a network of biochemical logic gates for reduction of the "analog" noise buildup. Experiments for three coupled enzymatic AND gates are reported, illustrating our procedure.…

Molecular Networks · Quantitative Biology 2010-10-12 Vladimir Privman , Mary A. Arugula , Jan Halamek , Marcos Pita , Evgeny Katz

We report an experimental evaluation of the "input-output surface" for a biochemical AND gate. The obtained data are modeled within the rate-equation approach, with the aim to map out the gate function and cast it in the language of logic…

Molecular Networks · Quantitative Biology 2010-10-12 V. Privman , G. Strack , D. Solenov , M. Pita , E. Katz

We review models and approaches for error-control in order to prevent the buildup of noise when gates for digital chemical and biomolecular computing based on (bio)chemical reaction processes are utilized to realize stable, scalable…

Soft Condensed Matter · Physics 2011-02-15 Vladimir Privman

The dynamics of a quantum XOR gate operation in a two-qubit system being coupled to a bath of quantum harmonic oscillators is investigated. Upon applying the numerical quasiadiabatic propagator path integral method, we obtain the…

Condensed Matter · Physics 2008-01-29 Michael Thorwart , Peter Hänggi

Synthetic active colloidal systems are being studied extensively because of the diverse and often unusual phenomena these nonequilibrium systems manifest, and their potential applications in fields ranging from biology to material science.…

Soft Condensed Matter · Physics 2023-02-16 Jiang-Xing Chen , Jia-Qi Hu , Raymond Kapral

We present a scheme of XOR/XNOR logic gate, based on non phase-matched noncollinear second harmonic generation from a medium of suitable crystalline symmetry, Gallium nitride. The polarization of the noncollinear generated beam is a…

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