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In multiobjective optimization, the result of an optimization algorithm is a set of efficient solutions from which the decision maker selects one. It is common that not all the efficient solutions can be computed in a short time and the…

Neural and Evolutionary Computing · Computer Science 2024-03-20 Miguel Ángel Domínguez-Ríos , Francisco Chicano , Enrique Alba

Pareto optimization via evolutionary multi-objective algorithms has been shown to efficiently solve constrained monotone submodular functions. Traditionally when solving multiple problems, the algorithm is run for each problem separately.…

Neural and Evolutionary Computing · Computer Science 2026-04-17 Liam Wigney , Frank Neumann

The discovery of therapeutic molecules is fundamentally a multi-objective optimization problem. One formulation of the problem is to identify molecules that simultaneously exhibit strong binding affinity for a target protein, minimal…

Quantitative Methods · Quantitative Biology 2023-10-17 Jenna C. Fromer , David E. Graff , Connor W. Coley

Chemotherapy is one of the primary modalities of cancer treatment. Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens. One way to alleviate this burden and…

Optimization and Control · Mathematics 2021-11-04 Temitayo Ajayi , Seyedmohammadhossein Hosseinian , Andrew J. Schaefer , Clifton D. Fuller

Multiobjective optimization plays an increasingly important role in modern applications, where several criteria are often of equal importance. The task in multiobjective optimization and multiobjective optimal control is therefore to…

In this paper, we propose a variable metric method for unconstrained multiobjective optimization problems (MOPs). First, a sequence of points is generated using different positive definite matrices in the generic framework. It is proved…

Optimization and Control · Mathematics 2022-07-18 Jian Chen , Gaoxi Li , Xinmin Yang

Resource constrained project scheduling is an important combinatorial optimisation problem with many practical applications. With complex requirements such as precedence constraints, limited resources, and finance-based objectives, finding…

Neural and Evolutionary Computing · Computer Science 2022-10-21 Dhananjay R. Thiruvady , Su Nguyen , Christian Blum , Andreas T. Ernst

We propose a novel optimization framework for computing the medial axis transform that simultaneously preserves the medial structure and ensures high medial mesh quality. The medial structure, consisting of interconnected sheets, seams, and…

Graphics · Computer Science 2025-10-14 Ningna Wang , Rui Xu , Yibo Yin , Zichun Zhong , Taku Komura , Wenping Wang , Xiaohu Guo

This paper presents a low-overhead optimizer for the ubiquitous sparse matrix-vector multiplication (SpMV) kernel. Architectural diversity among different processors together with structural diversity among different sparse matrices lead to…

Performance · Computer Science 2017-11-16 Athena Elafrou , Georgios Goumas , Nektarios Koziris

We present a novel application of Tensor Network methods in cancer treatment as a potential tool to solve the dose optimization problem in radiotherapy. In particular, the Intensity-Modulated Radiation Therapy (IMRT) technique - that allows…

Medical Physics · Physics 2021-08-11 Samuele Cavinato , Timo Felser , Marco Fusella , Marta Paiusco , Simone Montangero

Artificial intelligence-based radiation therapy (RT) planning has the potential to reduce planning time and inter-planner variability, improving efficiency and consistency in clinical workflows. Most existing automated approaches rely on…

Iterative solutions of sparse linear systems and sparse eigenvalue problems have a fundamental role in vital fields of scientific research and engineering. The crucial computing kernel for such iterative solutions is the multiplication of a…

Data Structures and Algorithms · Computer Science 2022-12-16 Thaha Mohammed , Rashid Mehmood

Energy minimization has been an intensely studied core problem in computer vision. With growing image sizes (2D and 3D), it is now highly desirable to run energy minimization algorithms in parallel. But many existing algorithms, in…

Computer Vision and Pattern Recognition · Computer Science 2015-03-06 K. S. Sesh Kumar , Alvaro Barbero , Stefanie Jegelka , Suvrit Sra , Francis Bach

We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a…

Medical Physics · Physics 2022-07-28 Florian Barkmann , Yair Censor , Niklas Wahl

Purpose: To demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy. Methods: Recently, a fast and accurate Graphics Processor Unit…

Medical Physics · Physics 2016-10-11 H. Wan Chan Tseung , J. Ma , C. R. Kreofsky , D. Ma , C. Beltran

We present an algorithm for planning trajectories that avoid obstacles and satisfy key-door precedence specifications expressed with a fragment of signal temporal logic. Our method includes a novel exact convex partitioning of the obstacle…

Systems and Control · Electrical Eng. & Systems 2026-04-02 Shilin You , Gael Luna , Juned Shaikh , David Gostin , Yu Xiang , Justin Koeln , Tyler Summers

The rapid development of virtual network architecture makes it possible for wireless network to be widely used. With the popularity of artificial intelligence (AI) industry in daily life, efficient resource allocation of wireless network…

Networking and Internet Architecture · Computer Science 2022-02-07 Chao Wang , Tao Dong , Youxiang Duan , Qifeng Sun , Peiying Zhang

The Project Optimus initiative by the FDA's Oncology Center of Excellence is widely viewed as a groundbreaking effort to change the $\textit{status quo}$ of conventional dose-finding strategies in oncology. Unlike in other therapeutic areas…

Applications · Statistics 2023-04-14 Zhenghao Jiang , Gu Mi , Ji Lin , Christelle Lorenzato , Yuan Ji

We propose a surrogate-assisted reference vector adaptation (SRVA) method to solve expensive multi- and many-objective optimization problems with various Pareto front shapes. SRVA is coupled with a multi-objective Bayesian optimization…

Machine Learning · Computer Science 2021-10-12 Nobuo Namura

Optimization problems with set-valued objective functions arise in contexts such as multi-stage optimization with vector-valued objectives. The aim is to identify an optimizer -- a feasible point with an optimal objective value -- based on…

Optimization and Control · Mathematics 2024-09-27 Andreas Löhne
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