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The recent discovery of universal principles underlying many complex networks occurring across a wide range of length scales in the biological world has spurred physicists in trying to understand such features using techniques from…

Biological Physics · Physics 2015-05-13 Sitabhra Sinha

This paper studies a constrained optimization problem over networked systems with an undirected and connected communication topology. The algorithm proposed in this work utilizes singular perturbation, dynamic average consensus, and saddle…

Optimization and Control · Mathematics 2017-10-24 Phuong Huu Hoang , Hyo-Sung Ahn

Many physical and biological systems can be studied using complex network theory, a new statistical physics understanding of graph theory. The recent application of complex network theory to the study of functional brain networks generated…

Neurons and Cognition · Quantitative Biology 2014-06-17 D. Papo , M. Zanin , J. A. Pineda-Pardo , S. Boccaletti , J. M. Buldú

In a recent paper, it has been suggested that the controllability of a diffusively coupled complex network, subject to localized feedback loops at some of its vertices, can be assessed by means of a Master Stability Function approach, where…

Disordered Systems and Neural Networks · Physics 2007-08-09 Francesco Sorrentino

Biological networks provide insight into the complex organization of biological processes in a cell at the system level. They are an effective tool for understanding the comprehensive map of functional interactions, finding the functional…

Molecular Networks · Quantitative Biology 2017-09-14 Somaye Hashemifar

Dynamical networks are powerful tools for modeling a broad range of complex systems, including financial markets, brains, and ecosystems. They encode how the basic elements (nodes) of these systems interact altogether (via links) and evolve…

Physics and Society · Physics 2019-03-13 Edward Laurence , Nicolas Doyon , Louis J Dubé , Patrick Desrosiers

Regulatory networks describe the interactions between molecular or cellular regulators, like transcription factors and genes in gene regulatory networks, kinases and their receptors in signalling networks, or neurons in neural networks. A…

Molecular Networks · Quantitative Biology 2022-12-29 Niklas Bonacker , Johannes Berg

Two different types of directed networks are investigated, transcriptional regulation networks and neural networks. The directed network structure are studied and also shown to reflect the different processes taking place on the networks.…

Disordered Systems and Neural Networks · Physics 2016-08-16 Andreas Grönlund

Cellular response to a perturbation is the result of a dynamic system of biological variables linked in a complex network. A major challenge in drug and disease studies is identifying the key factors of a biological network that are…

Applications · Statistics 2014-09-02 Lisa M. Pham , Luis Carvalho , Scott Schaus , Eric D. Kolaczyk

Observability and controllability are essential concepts to the design of predictive observer models and feedback controllers of networked systems. For example, noncontrollable mathematical models of real systems have subspaces that…

Neurons and Cognition · Quantitative Biology 2018-04-18 Andrew J. Whalen , Sean N. Brennan , Timothy D. Sauer , Steven J. Schiff

Network systems consist of subsystems and their interconnections, and provide a powerful framework for analysis, modeling and control of complex systems. However, subsystems may have high-dimensional dynamics, and the amount and nature of…

Optimization and Control · Mathematics 2020-12-07 Xiaodong Cheng , Jacquelien M. A. Scherpen

Rhythmic activities that alternate between coherent and incoherent phases are ubiquitous in chemical, ecological, climate, or neural systems. Despite their importance, general mechanisms for their emergence are little understood. In order…

Adaptation and Self-Organizing Systems · Physics 2022-06-01 Max Thiele , Rico Berner , Peter A. Tass , Eckehard Schöll , Serhiy Yanchuk

Recently, self-sustained oscillations in complex networks consisting of nonoscillatory nodes (network oscillators) have attracted great interest in diverse natural and social fields. Due to complexity of network behaviors, little is known…

Adaptation and Self-Organizing Systems · Physics 2011-03-29 Xuhong Liao , Weiming Ye , Xiaodong Huang , Qinzhi Xia , Xuhui Huang , Pengfei Li , Yu Qian , Xiaoqing Huang , Gang Hu

In this paper, controllability of undirected networked systems with {diffusively coupled subsystems} is considered, where each subsystem is of {identically {\emph{fixed}}} general high-order single-input-multi-output dynamics. The…

Systems and Control · Electrical Eng. & Systems 2020-04-21 Yuan Zhang , Yuanqing Xia , Han Gao , Guangchen Zhang

The complexity of the cells can be described and understood by a number of networks such as protein-protein interaction, cytoskeletal, organelle, signalling, gene transcription and metabolic networks. All these networks are highly dynamic…

Molecular Networks · Quantitative Biology 2007-07-26 Mate S. Szalay , Istvan A. Kovacs , Tamas Korcsmaros , Csaba Bode , Peter Csermely

This article determines and characterizes the minimal number of actuators needed to ensure structural controllability of a linear system under structural alterations that can severe the connection between any two states. We assume that…

Systems and Control · Computer Science 2017-03-23 Priyanka Dey , Niranjan Balachandran , Debasish Chatterjee

This paper presents an unusual view of interference wireless networks based on complex system thinking. To proceed with this analysis, a literature review of the different applications of complex systems is firstly presented to illustrate…

Information Theory · Computer Science 2013-03-13 Pedro H. J. Nardelli , Paulo Cardieri , William A. Kretzschmar , Matti Latva-aho

Traditional approaches to understanding the brain's resilience to neuropathology have identified neurophysiological variables, often described as brain or cognitive 'reserve,' associated with better outcomes. However, mechanisms of function…

Neurons and Cognition · Quantitative Biology 2017-01-18 John D. Medaglia , Fabio Pasqualetti , Roy H. Hamilton , Sharon L. Thompson-Schill , Danielle S. Bassett

Much of contemporary systems biology owes its success to the abstraction of a network, the idea that diverse kinds of molecular, cellular, and organismal species and interactions can be modeled as relational nodes and edges in a graph of…

Molecular Networks · Quantitative Biology 2017-05-26 Joseph L. Natale , David Hofmann , Damian G. Hernández , Ilya Nemenman

Social science studies dealing with control in networks typically resort to heuristics or describing the static control distribution. Optimal policies, however, require interventions that optimize control over a socioeconomic network…

Social and Information Networks · Computer Science 2021-08-24 Jannes Nys , Milan van den Heuvel , Koen Schoors , Bruno Merlevede