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The construction of a reaction network containing all relevant intermediates and elementary reactions is necessary for the accurate description of chemical processes. In the case of a complex chemical reaction (involving, for instance, many…

Chemical Physics · Physics 2017-12-19 Gregor N. Simm , Markus Reiher

The use of external restraints is ubiquitous in advanced molecular simulation techniques. In general, restraints serve to reduce the configurational space that is available for sampling, thereby reducing the computational demands associated…

Granular matter takes many paths to pack. Gentle compression, compaction or repetitive tapping can happen in natural and industrial processes. The path influences the packing microstructure, and thus macroscale properties, particularly for…

Soft Condensed Matter · Physics 2023-10-26 A. P. Santos , Ishan Srivastava , Leonardo E. Silbert , Jeremy B. Lechman , Gary S. Grest

Tensor networks have historically proven to be of great utility in providing compressed representations of wave functions that can be used for calculation of eigenstates. Recently, it has been shown that a variety of these networks can be…

Quantum Physics · Physics 2024-06-25 Amartya Bose

In this work, we present a workspace-based planning framework, which though using redundant workspace key-points to represent robot states, can take advantage of the interpretable geometric information to derive good quality collision-free…

Robotics · Computer Science 2022-06-17 Weifu Wang , Ping Li

Reaction rate equations are ordinary differential equations that are frequently used to describe deterministic chemical kinetics at the macroscopic scale. At the microscopic scale, the chemical kinetics is stochastic and can be captured by…

Soft Condensed Matter · Physics 2021-05-12 Ariana Torres-Knoop , Ivan Kryven

Techniques for simulating molecules whose conformations satisfy constraints are presented. A method for selecting appropriate moves in Monte Carlo simulations is given. The resulting moves not only obey the constraints but also maintain…

Computational Physics · Physics 2007-05-23 Charles F. F. Karney , Jason E. Ferrara

This study presents a benchmark for evaluating action-constrained reinforcement learning (RL) algorithms. In action-constrained RL, each action taken by the learning system must comply with certain constraints. These constraints are crucial…

Machine Learning · Computer Science 2023-06-30 Kazumi Kasaura , Shuwa Miura , Tadashi Kozuno , Ryo Yonetani , Kenta Hoshino , Yohei Hosoe

We propose a reinforcement learning based method to identify important configurations that connect reactant and product states along chemical reaction paths. By shooting multiple trajectories from these configurations, we can generate an…

Chemical Physics · Physics 2023-05-30 Senwei Liang , Aditya N. Singh , Yuanran Zhu , David T. Limmer , Chao Yang

We consider the application of Kramers theory to the microscopic calculation of rates of conformational transitions of macromolecules. The main difficulty in such an approach is to locate the transition state in a huge configuration space.…

Biomolecules · Quantitative Biology 2008-09-02 Marcello Sega , Pietro Faccioli , Francesco Pederiva , Henri Orland

Perimeter control maintains high traffic efficiency within protected regions by controlling transfer flows among regions to ensure that their traffic densities are below critical values. Existing approaches can be categorized as either…

Machine Learning · Computer Science 2023-06-01 Xiaocan Li , Ray Coden Mercurius , Ayal Taitler , Xiaoyu Wang , Mohammad Noaeen , Scott Sanner , Baher Abdulhai

We propose a general approach to directly implement rate constraints on the discretization mesh for all collocation methods, for both state and input variables. Unlike conventional approaches that may lead to singular control arcs, the…

Optimization and Control · Mathematics 2021-12-16 Yuanbo Nie , Eric Kerrigan

The non-Markovian nature of polymer motions is accounted for in folding kinetics, using frequency-dependent friction. Folding, like many other problems in the physics of disordered systems, involves barrier crossing on a correlated energy…

Statistical Mechanics · Physics 2009-10-30 Steven S. Plotkin , Peter G. Wolynes

We consider the interacting Bose gas in the thermodynamic limit in a large box in $\R^d$ at positive temperature $1/\beta\in(0,\infty)$ with particle density $\sim\rho\in(0,\infty)$. We follow a path-integral approach and adopt from \cite…

Probability · Mathematics 2026-04-17 Wolfgang König

We discuss chemical reaction networks and metabolic pathways based on stoichiometric network analysis, and introduce deformed toric ideal constraints by the algebraic geometrical approach. This paper concerns steady state flux of chemical…

Molecular Networks · Quantitative Biology 2013-04-24 Masamichi Sato , Kenji Fukumizu

In this work we address the problem of finding feasible policies for Constrained Markov Decision Processes under probability one constraints. We argue that stationary policies are not sufficient for solving this problem, and that a rich…

Machine Learning · Computer Science 2023-02-14 Agustin Castellano , Hancheng Min , Juan Bazerque , Enrique Mallada

We present a novel method for learning hybrid force/position control from demonstration. We learn a dynamic constraint frame aligned to the direction of desired force using Cartesian Dynamic Movement Primitives. In contrast to approaches…

Robotics · Computer Science 2022-05-05 Adam Conkey , Tucker Hermans

Behavior Trees (BTs) provide a structured and reactive framework for decision-making, commonly used to switch between sub-controllers based on environmental conditions. Reinforcement Learning (RL), on the other hand, can learn near-optimal…

Artificial Intelligence · Computer Science 2026-02-12 Finn Rietz , Mart Kartašev , Petter Ögren , Johannes A. Stork

We provide a rigorous definition of free-energy transduction and its efficiency in arbitrary -- linear or nonlinear -- open chemical reaction networks (CRNs) operating at steady state. Our method is based on the knowledge of the…

Molecular Networks · Quantitative Biology 2022-06-15 Artur Wachtel , Riccardo Rao , Massimiliano Esposito

Transition State Theory is a central cornerstone in reaction dynamics. Its key step is the identification of a dividing surface that is crossed only once by all reactive trajectories. This assumption is often badly violated, especially when…

Chemical Physics · Physics 2015-05-07 F. Revuelta , Thomas Bartsch , R. M. Benito , F. Borondo
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