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Typically used as a tool for Monte Carlo simulation of high energy physics experiments, GEANT4 is increasingly being employed for the simulation of complex radiotherapy treatments. Often the specification of components within a clinical…

Medical Physics · Physics 2011-05-06 Christopher M Poole , Iwan Cornelius , Jamie V Trapp , Christian M Langton

We investigate the feasibility of high performance scientific computation using cloud computers as an alternative to traditional computational tools. The availability of these large, virtualized pools of compute resources raises the…

Materials Science · Physics 2009-01-05 J. J. Rehr , J. P. Gardner , M. Prange , L. Svec , F. Vila

The claim that Monte Carlo is the most accurate method is a case of misattributed credit. This claim is based on experience with advanced systems MCNPX, Geant4 and EGS. These systems achieve remarkable performance because they use most…

Medical Physics · Physics 2026-03-13 Oleg N Vassiliev , Radhe Mohan

Skin dose in radiotherapy is a key issue for reducing patient side effects, but dose calculations in this high-gradient region remains a challenge. To support radiation therapists and medical physicist in their decisions, a computational…

Purpose: Monte Carlo methods are considered the gold standard for dosimetric computations in radiotherapy. Their execution time is however still an obstacle to the routine use of Monte Carlo packages in a clinical setting. To address this…

Medical Physics · Physics 2015-03-17 Sami Hissoiny , Hugo Bouchard , Benoît Ozell , Philippe Després

This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customization and precision. As adaptive radiotherapy and other…

Medical Physics · Physics 2024-04-24 Jason Holmes , Hongying Feng , Lian Zhang , Michael Fix , Steve B. Jiang , Wei Liu

Background: Accurate and fast dose calculation is essential for optimizing carbon ion therapy. Existing machine learning (ML) models have been developed for other radiotherapy modalities. They use patient data with uniform CT imaging…

Cloud computing is a powerful new technology that is widely used in the business world. Recently, we have been investigating the benefits it offers to scientific computing. We have used three workflow applications to compare the performance…

Instrumentation and Methods for Astrophysics · Physics 2015-03-17 G. Bruce Berriman , Ewa Deelman , Gideon Juve , Moira Regelson , Peter Plavchan

Purpose: Very fast Monte Carlo (MC) simulations of proton transport have been implemented recently on GPUs. However, these usually use simplified models for non-elastic (NE) proton-nucleus interactions. Our primary goal is to build a…

Medical Physics · Physics 2015-06-11 H. Wan Chan Tseung , J. Ma , C. Beltran

Cloud providers sell their idle capacity on markets through an auction-like mechanism to increase their return on investment. The instances sold in this way are called spot instances. In spite that spot instances are usually 90% cheaper…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-03-08 Chenhao Qu , Rodrigo N. Calheiros , Rajkumar Buyya

Quantum many-body systems (QMBs) are some of the most challenging physical systems to simulate numerically. Methods involving approximations for tensor network (TN) contractions have proven to be viable alternatives to algorithms such as…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-01-14 Justin A. Reyes , Eduardo R. Mucciolo , Dan Marinescu

We introduce a novel learning framework for accelerated Monte Carlo (MC) dose calculation termed Energy-Shifting. This approach leverages deep learning to synthesize highly complex polyenergetic dose distributions directly from simple…

Next generation online and real-time adaptive radiotherapy workflows require precise particle transport simulations in sub-second times, which is unfeasible with current analytical pencil beam algorithms (PBA) or stochastic Monte Carlo (MC)…

Medical Physics · Physics 2022-02-08 Oscar Pastor-Serrano , Zoltán Perkó

Due to the massive size of the neural network models and training datasets used in machine learning today, it is imperative to distribute stochastic gradient descent (SGD) by splitting up tasks such as gradient evaluation across multiple…

Machine Learning · Computer Science 2020-03-13 Xiaoxi Zhang , Jianyu Wang , Gauri Joshi , Carlee Joe-Wong

The simulation of radioactive decays is a common task in Monte-Carlo systems such as Geant4. Usually, a system either uses an approach focusing on the simulations of every individual decay or an approach which simulates a large number of…

We present a case study of a cloud-based computational workflow for processing large astronomical data sets from the Murchison Widefield Array (MWA) cosmology experiment. Cloud computing is well-suited to large-scale, episodic computation…

Instrumentation and Methods for Astrophysics · Physics 2021-03-04 Ruby Byrne , Daniel Jacobs

Online adaptive radiation therapy (ART) is an attractive concept that promises the ability to deliver an optimal treatment in response to the inter-fraction variability in patient anatomy. However, it has yet to be realized due to technical…

Medical Physics · Physics 2015-05-14 Xuejun Gu , Dongju Choi , Chunhua Men , Hubert Pan , Amitava Majumdar , Steve B. Jiang

The diverse near-Earth radiation environment due to cosmic rays and solar radiation has direct impact on human civilization. In the present and upcoming era of increasing air transfer, it is important to have precise idea of radiation dose…

Medical Physics · Physics 2021-12-16 Abhijit Roy , Ritabrata Sarkar , Choonsik Lee

A Geant4 based simulation tool has been developed to perform Monte Carlo modelling of a 6 MV VarianTM iX clinac. The computer aided design interface of Geant4 was used to accurately model the LINAC components, including the Millenium…

We present Generative Monte Carlo (GMC), a novel paradigm for particle transport simulation that integrates generative artificial intelligence directly into the stochastic solution of the linear Boltzmann equation. By reformulating the…

Computational Physics · Physics 2025-12-17 Joseph A. Farmer , Aidan Murray , Johannes Krotz , Ryan G. McClarren