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Microarrays have been developed that tile the entire nonrepetitive genomes of many different organisms, allowing for the unbiased mapping of active transcription regions or protein binding sites across the entire genome. These tiling array…

Applications · Statistics 2009-10-13 W. Evan Johnson , X. Shirley Liu , Jun S. Liu

This project aims to break down large pathology images into small tiles and then cluster those tiles into distinct groups without the knowledge of true labels, our analysis shows how difficult certain aspects of clustering tumorous and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Mostafa Ibrahim , Kevin Bryson

Gene expression is a complex phenomenon involving numerous interlinked variables, and studying these variables to control expression is essential in bioengineering and biomanufacturing. While cloning techniques for achieving plasmid…

Quantitative Methods · Quantitative Biology 2025-01-30 Khushank Singhal , Harry Adamson , Thomas Baer , Howard Salis , Melik Demirel

Biological systems, from cells to organisms, must respond to the ever changing environment in order to survive and function. This is not a simple task given the often random nature of the signals they receive, as well as the intrinsically…

Quantitative Methods · Quantitative Biology 2015-07-09 Aleksandra M. Walczak

Unsupervised clustering, also known as natural clustering, stands for the classification of data according to their similarities. Here we study this problem from the perspective of complex networks. Mapping the description of data…

Data Analysis, Statistics and Probability · Physics 2012-08-22 Clara Granell , Sergio Gomez , Alex Arenas

Despite the success and popularity of oligonucleotide arrays as a high-throughput technique for measuring mRNA expression levels, quantitative calibration studies have until now been limited. The main reason is that suitable data was not…

Biological Physics · Physics 2007-05-23 Felix Naef , Nicholas D. Socci , Marcelo Magnasco

Unsupervised machine learning, and in particular data clustering, is a powerful approach for the analysis of datasets and identification of characteristic features occurring throughout a dataset. It is gaining popularity across scientific…

Mesoscale and Nanoscale Physics · Physics 2021-03-23 Maria El Abbassi , Jan Overbeck , Oliver Braun , Michel Calame , Herre S. J. van der Zant , Mickael L. Perrin

The goal of this paper is to discover a set of discriminative patches which can serve as a fully unsupervised mid-level visual representation. The desired patches need to satisfy two requirements: 1) to be representative, they need to occur…

Computer Vision and Pattern Recognition · Computer Science 2012-08-21 Saurabh Singh , Abhinav Gupta , Alexei A. Efros

Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiplechromosomes. The measured probes are by themselves less interesting…

Applications · Statistics 2016-11-16 John Nagorski , Genevera I. Allen

Active learning generally involves querying the most representative samples for human labeling, which has been widely studied in many fields such as image classification and object detection. However, its potential has not been explored in…

Computer Vision and Pattern Recognition · Computer Science 2020-12-10 Jun Wang , Shaoguo Wen , Kaixing Chen , Jianghua Yu , Xin Zhou , Peng Gao , Changsheng Li , Guotong Xie

Segmentation of very large images is a common problem in microscopy, medical imaging or remote sensing. The problem is usually addressed by sliding window inference, which can theoretically lead to seamlessly stitched predictions. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Elena Buglakova , Anwai Archit , Edoardo D'Imprima , Julia Mahamid , Constantin Pape , Anna Kreshuk

Unsupervised feature selection aims to identify a compact subset of features that captures the intrinsic structure of data without supervised label. Most existing studies evaluate the performance of methods using the single-label dataset…

Machine Learning · Computer Science 2026-02-10 Gyu-Il Kim , Dae-Won Kim , Jaesung Lee

We consider the unsupervised learning problem of assigning labels to unlabeled data. A naive approach is to use clustering methods, but this works well only when data is properly clustered and each cluster corresponds to an underlying…

Machine Learning · Computer Science 2013-05-02 Marthinus Christoffel du Plessis , Masashi Sugiyama

Approaching new data can be quite deterrent; you do not know how your categories of interest are realized in it, commonly, there is no labeled data at hand, and the performance of domain adaptation methods is unsatisfactory. Aiming to…

Computation and Language · Computer Science 2020-10-20 Eyal Shnarch , Leshem Choshen , Guy Moshkowich , Noam Slonim , Ranit Aharonov

The study of topological bandstructures is an active area of research in condensed matter physics and beyond. Here, we combine recent progress in this field with developments in machine-learning, another rising topic of interest.…

Mesoscale and Nanoscale Physics · Physics 2020-06-03 Mathias S. Scheurer , Robert-Jan Slager

Unsupervised patient stratification is essential for disease subtype discovery, yet, despite growing evidence of molecular heterogeneity of non-oncological diseases, popular methods are benchmarked primarily using cancers with mutually…

Classification is one of the most popular and widely used supervised learning tasks, which categorizes objects into predefined classes based on known knowledge. Classification has been an important research topic in machine learning and…

Machine Learning · Computer Science 2015-03-13 Jian-Ping Mei , Chee-Keong Kwoh , Peng Yang , Xiao-Li Li

A gene expression compendium is a heterogeneous collection of gene expression experiments assembled from data collected for diverse purposes. The widely varied experimental conditions and genetic backgrounds across samples creates a…

Quantitative Methods · Quantitative Biology 2022-03-29 Alexandra J. Lee , Taylor Reiter , Georgia Doing , Julia Oh , Deborah A. Hogan , Casey S. Greene

Time series constitute a challenging data type for machine learning algorithms, due to their highly variable lengths and sparse labeling in practice. In this paper, we tackle this challenge by proposing an unsupervised method to learn…

Machine Learning · Computer Science 2020-01-06 Jean-Yves Franceschi , Aymeric Dieuleveut , Martin Jaggi

Few-shot node classification is tasked to provide accurate predictions for nodes from novel classes with only few representative labeled nodes. This problem has drawn tremendous attention for its projection to prevailing real-world…

Machine Learning · Computer Science 2022-12-13 Zhen Tan , Song Wang , Kaize Ding , Jundong Li , Huan Liu
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