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There are many ways to represent a molecule as input to a machine learning model and each is associated with loss and retention of certain kinds of information. In the interest of preserving three-dimensional spatial information, including…

Machine Learning · Computer Science 2019-12-11 Jocelyn Sunseri , David Ryan Koes

In this paper we describe an autotuning tool for optimization of OpenMP applications on highly multicore and multithreaded architectures. Our work was motivated by in-depth performance analysis of scientific applications and synthetic…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-01-17 Jakub Katarzyński , Maciej Cytowski

Exploiting the full computational power of always deeper hierarchical multiprocessor machines requires a very careful distribution of threads and data among the underlying non-uniform architecture. The emergence of multi-core chips and NUMA…

Programming Languages · Computer Science 2007-06-15 Samuel Thibault , François Broquedis , Brice Goglin , Raymond Namyst , Pierre-André Wacrenier

Quantization is a critical technique for accelerating LLM inference by reducing memory footprint and improving computational efficiency. Among various schemes, 4-bit weight and 8-bit activation quantization (W4A8) offers a strong balance…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-03 Huanqi Hu , Bowen Xiao , Shixuan Sun , Jianian Yin , Zhexi Zhang , Xiang Luo , Chengquan Jiang , Weiqi Xu , Xiaoying Jia , Xin Liu , Minyi Guo

The fragmented landscape of quantum computer benchmarks, characterized by system-specific tools and inconsistent evaluation methodologies, hinders reliable cross-platform performance assessment. We introduce Metriq, an open-source…

Modern software packages have become increasingly complex with millions of lines of code and references to many external libraries. Redundant operations are a common performance limiter in these code bases. Missed compiler optimization…

Performance · Computer Science 2019-02-15 Pengfei Su , Shasha Wen , Hailong Yang , Milind Chabbi , Xu Liu

We carry out a comparative performance study of multi-core CPUs, GPUs and Intel Xeon Phi (Many Integrated Core - MIC) with a microscopy image analysis application. We experimentally evaluate the performance of computing devices on core…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-05-15 George Teodoro , Tahsin Kurc , Guilherme Andrade , Jun Kong , Renato Ferreira , Joel Saltz

Serving large language models (LLMs) efficiently remains challenging due to the high memory and latency overhead of key-value (KV) cache access during autoregressive decoding. We present \textbf{TinyServe}, a lightweight and extensible…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-17 Dong Liu , Yanxuan Yu

Tick is a statistical learning library for Python~3, with a particular emphasis on time-dependent models, such as point processes, and tools for generalized linear models and survival analysis. The core of the library is an optimization…

Machine Learning · Statistics 2018-03-16 Emmanuel Bacry , Martin Bompaire , Stéphane Gaïffas , Soren Poulsen

Multi-threaded programs are expected to improve responsiveness and conserve resources by dividing an application process into multiple threads for concurrent processing. However, due to scheduling and the interaction of multiple threads,…

Software Engineering · Computer Science 2024-09-26 Takumi Murata , Hiroaki Hashiura

Modern computing systems are limited in performance by the memory bandwidth available to processors, a problem known as the memory wall. Processing-in-Memory (PIM) promises to substantially improve this problem by moving processing closer…

Cryptography and Security · Computer Science 2025-04-24 Sahar Ghoflsaz Ghinani , Jingyao Zhang , Elaheh Sadredini

We present a performance model for bandwidth limited loop kernels which is founded on the analysis of modern cache based microarchitectures. This model allows an accurate performance prediction and evaluation for existing instruction codes.…

Performance · Computer Science 2009-05-07 Jan Treibig , Georg Hager

Ensuring that software performance does not degrade after a code change is paramount. A solution is to regularly execute software microbenchmarks, a performance testing technique similar to (functional) unit tests, which, however, often…

Software Engineering · Computer Science 2024-04-19 Christoph Laaber , Tao Yue , Shaukat Ali

Over the past few years, there has been an increased interest in including FPGAs in data centers and high-performance computing clusters along with GPUs and other accelerators. As a result, it has become increasingly important to have a…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-14 Mostafa Eghbali Zarch , Reece Neff , Michela Becchi

In the presence of accelerated fault rates, which are projected to be the norm on future exascale systems, it will become increasingly difficult for high-performance computing (HPC) applications to accomplish useful computation. Due to the…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-01-19 Saurabh Hukerikar , Keita Teranishi , Pedro C. Diniz , Robert F. Lucas

Typically, a memory request from a processor may need to go through many intermediate interconnect routers, directory node, owner node, etc before it is finally serviced. Current multiprocessors do not give preference to any particular…

Hardware Architecture · Computer Science 2016-06-21 Sandeep Navada , Anil Krishna

Analytic performance models are essential for understanding the performance characteristics of loop kernels, which consume a major part of CPU cycles in computational science. Starting from a validated performance model one can infer the…

Performance · Computer Science 2015-11-06 Julian Hammer , Georg Hager , Jan Eitzinger , Gerhard Wellein

Proxy-apps, or mini-apps, are simple self-contained benchmark codes with performance-relevant kernels extracted from real applications. Initially used to facilitate software-hardware co-design, they are a crucial ingredient for serious…

Computational Physics · Physics 2022-07-28 Rafael Ravedutti Lucio Machado , Jan Eitzinger , Harald Köstler , Gerhard Wellein

Similarity search in high-dimentional spaces is a pivotal operation found a variety of database applications. Recently, there has been an increase interest in similarity search for online content-based multimedia services. Those services,…

Multimedia · Computer Science 2012-09-04 George Teodoro , Eduardo Valle , Nathan Mariano , Ricardo Torres , Wagner Meira , Joel H. Saltz

Modern workloads are demanding increasingly larger memory capacity. Compute Express Link (CXL)-based memory tiering has emerged as a promising solution for addressing this problem by utilizing traditional DRAM alongside slow-tier CXL memory…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-04 Kevin Song , Jiacheng Yang , Zixuan Wang , Jishen Zhao , Sihang Liu , Gennady Pekhimenko