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We illustrate the main features of a recently proposed method based on ensemble density functional theory to divide rigorously a complex molecular system into its parts [M.H. Cohen and A. Wasserman, J. Phys. Chem. A 111, 2229 (2007)]. The…

Other Condensed Matter · Physics 2016-09-28 Morrel H. Cohen , Adam Wasserman , Kieron Burke

The study of immune cellular composition has been of great scientific interest in immunology because of the generation of multiple large-scale data. From the statistical point of view, such immune cellular data should be treated as…

Applications · Statistics 2022-04-22 Jinkyung Yoo , Zequn Sun , Michael Greenacre , Qin Ma , Dongjun Chung , Young Min Kim

Counting statistics of charge transfers in a point contact interacting with an arbitrary quantum system is studied. The theory for the charge specific density matrix is developed, allowing the evaluation of the probability of the outcome of…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 J. Rammer , A. L. Shelankov , J. Wabnig

Linear response theory describes quantum measurement with an arbitrary detector weakly coupled to a measured system. This description produces generic quantitative relation characterizing the detector that is analogous to the…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 D. V. Averin

An interesting inference drawn by some Covid-19 epidemiological models is that there exists a proportion of the population who are not susceptible to infection -- even at the start of the current pandemic. This paper introduces a model of…

Quantitative Methods · Quantitative Biology 2020-09-18 Thomas Parr , Anjali Bhat , Peter Zeidman , Aimee Goel , Alexander J. Billig , Rosalyn Moran , Karl J. Friston

Nonlinear density response theory is revisited focusing on the harmonically perturbed finite temperature uniform electron gas. Within the non-interacting limit, brute force quantum kinetic theory calculations for the quadratic, cubic,…

Quantum Gases · Physics 2023-05-23 Panagiotis Tolias , Tobias Dornheim , Zhandos A. Moldabekov , Jan Vorberger

I propose a general quantum hypothesis testing theory that enables one to test hypotheses about any aspect of a physical system, including its dynamics, based on a series of observations. For example, the hypotheses can be about the…

Quantum Physics · Physics 2012-04-30 Mankei Tsang

Based on our earlier works [Phys. Rev. B 75, 195127 (2007) & J. Chem. Phys. 128, 234703 (2008)], we propose a formally exact and numerically convenient approach to simulate time-dependent quantum transport from first-principles. The…

Chemical Physics · Physics 2015-05-18 Xiao Zheng , GuanHua Chen , Yan Mo , SiuKong Koo , Heng Tian , ChiYung Yam , YiJing Yan

Serology testing can identify past infection by quantifying the immune response of an infected individual providing important public health guidance. Individual immune responses are time-dependent, which is reflected in antibody…

Quantitative Methods · Quantitative Biology 2022-08-04 Prajakta Bedekar , Anthony J. Kearsley , Paul N. Patrone

Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to challenging problems of modern computing…

Cell Behavior · Quantitative Biology 2017-05-24 Alexandre de Castro , Carlos Frederico Fronza , Domingos Alves

The recently established resource theory of quantum coherence allows for a quantitative understanding of the superposition principle, with applications reaching from quantum computing to quantum biology. While different quantifiers of…

A nonparametric Bayesian approach is developed to determine quantum potentials from empirical data for quantum systems at finite temperature. The approach combines the likelihood model of quantum mechanics with a priori information over…

Statistical Mechanics · Physics 2009-10-31 J. C. Lemm , J. Uhlig , A. Weiguny

It is proposed that using both self-non-self and danger theories give a better understanding of how the immune system works. It is proposed that comparing immune system to police force is useful in this case since police responds both to…

Populations and Evolution · Quantitative Biology 2008-01-08 E. Ahmed , A. H. Hashish

The physical interpretation of the functioning of the adaptive immune system, which has been thoroughly characterized on genetic and molecular levels, provides a unique opportunity to define an adaptive self-organizing biological system in…

Molecular Networks · Quantitative Biology 2023-05-19 Jozsef Prechl

Count data frequently arises in biomedical applications, such as the length of hospital stay. However, their discrete nature poses significant challenges for appropriately modeling conditional quantiles, which are crucial for understanding…

Methodology · Statistics 2025-07-28 Yuta Yamauchi , Genya Kobayashi , Shonosuke Sugasawa

This paper addresses patient heterogeneity associated with prediction problems in biomedical applications. We propose a systematic hypothesis testing approach to determine the existence of patient subgroup structure and the number of…

Methodology · Statistics 2021-01-08 Xu Gao , Weining Shen , Jing Ning , Ziding Feng , Jianhua Hu

The aim of this work is to try to bridge over theoretical immunology and disordered statistical mechanics. Our long term hope is to contribute to the development of a quantitative theoretical immunology from which practical applications may…

Disordered Systems and Neural Networks · Physics 2015-05-18 Adriano Barra , Elena Agliari

In this work we focus on a recently introduced method [1] to construct the external potential $v$ that, for a given initial state, produces a prescribed time-dependent density in an interacting quantum many-body system. We show how this…

Quantum Physics · Physics 2014-12-12 S. E. B. Nielsen , M. Ruggenthaler , R. van Leeuwen

The development of therapeutic antibodies heavily relies on accurate predictions of how antigens will interact with antibodies. Existing computational methods in antibody design often overlook crucial conformational changes that antigens…

Quantitative Methods · Quantitative Biology 2025-03-05 Cheng Tan , Yijie Zhang , Zhangyang Gao , Yufei Huang , Haitao Lin , Lirong Wu , Fandi Wu , Mathieu Blanchette , Stan. Z. Li

The response of particle density to a dilation of a periodic potential in an insulator, with or without a fixed background potential or a magnetic field, is shown to be quantized. A similar phenomenon occurs in a quantum Hall system, where…

Condensed Matter · Physics 2009-10-22 Q. Niu