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The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean…

Molecular Networks · Quantitative Biology 2009-11-10 Stuart Kauffman , Carsten Peterson , Björn Samuelsson , Carl Troein

Gene regulatory networks (GRNs) play a central role in cellular decision-making. Understanding their structure and how it impacts their dynamics constitutes thus a fundamental biological question. GRNs are frequently modeled as Boolean…

Molecular Networks · Quantitative Biology 2024-01-19 Claus Kadelka , Taras-Michael Butrie , Evan Hilton , Jack Kinseth , Addison Schmidt , Haris Serdarevic

An automata network (AN) is a finite graph where each node holds a state from a finite alphabet and is equipped with a local map defining the evolution of the state of the node depending on its neighbors. The global dynamics of the network…

Computational Complexity · Computer Science 2021-05-19 Martín Ríos Wilson , Guillaume Theyssier

This paper presents a unified framework for analyzing the input-output behavior of discrete time complex networks viewed as open systems. Importantly, we focus on systems that are inherently modeled in discrete time-such as opinion…

Physics and Society · Physics 2025-11-25 Amirhossein Nazerian , MAlbor Asllani , Melvyn Tyloo , Francesco Sorrentino

Boolean networks at the critical point have been a matter of debate for many years as, e.g., scaling of number of attractor with system size. Recently it was found that this number scales superpolynomially with system size, contrary to a…

Disordered Systems and Neural Networks · Physics 2009-11-10 Konstantin Klemm , Stefan Bornholdt

Chaos control in Random Boolean networks is implemented by freezing part of the network to drive it from chaotic to ordered phase. However, controlled nodes are only viewed as passive blocks to prevent perturbation spread. This paper…

Cellular Automata and Lattice Gases · Physics 2015-05-20 Nan Jiang , Shijian Chen

We introduce simple models of genetic regulatory networks and we proceed to the mathematical analysis of their dynamics. The models are discrete time dynamical systems generated by piecewise affine contracting mappings whose variables…

Dynamical Systems · Mathematics 2007-05-23 Ricardo Coutinho , Bastien Fernandez , Ricardo Lima , Arnaud Meyroneinc

We provide the first classification of different types of Random Boolean Networks (RBNs). We study the differences of RBNs depending on the degree of synchronicity and determinism of their updating scheme. For doing so, we first define…

Computational Complexity · Computer Science 2007-05-23 Carlos Gershenson

Graphlet counting is an important problem as it has numerous applications in several fields, including social network analysis, biological network analysis, transaction network analysis, etc. Most of the practical networks are dynamic. A…

Data Structures and Algorithms · Computer Science 2023-08-29 Hriday G , Pranav Saikiran Sista , Apurba Das

The co-evolution of network topology and dynamics is studied in an evolutionary Boolean network model that is a simple model of gene regulatory network. We find that a critical state emerges spontaneously resulting from interplay between…

Statistical Mechanics · Physics 2007-05-23 Min Liu , Kevin E. Bassler

It has been shown that uniform as well as non-uniform cellular automata (CA) can be evolved to perform certain computational tasks. Random Boolean networks are a generalization of two-state cellular automata, where the interconnection…

Disordered Systems and Neural Networks · Physics 2007-05-23 Bertrand Mesot , Christof Teuscher

In this report, we present a formal approach that addresses the problem of emergence of phase transitions in stochastic and attractive nonlinear threshold Boolean automata networks. Nonlinear networks considered are informally defined on…

Discrete Mathematics · Computer Science 2010-11-23 Jacques Demongeot , Sylvain Sené

Boolean networks can be viewed as functions on the set of binary strings of a given length, described via logical rules. They were introduced as dynamic models into biology, in particular as logical models of intracellular regulatory…

Dynamical Systems · Mathematics 2025-04-16 J. García Galofre , M. Pérez Millán , A. Galarza Rial , R. Laubenbacher , A. Dickenstein

The dynamical organization in the presence of noise of a Boolean neural network with random connections is analyzed. For low levels of noise, the system reaches a stationary state in which the majority of its elements acquire the same…

Disordered Systems and Neural Networks · Physics 2007-05-23 Cristian Huepe , Maximino Aldana

We propose the use of Deterministic Generalized Asynchronous Random Boolean Networks [Gershenson, 2002] as models of contextual deterministic discrete dynamical systems. We show that changes in the context have drastic effects on the global…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Carlos Gershenson , Jan Broekaert , Diederik Aerts

In this paper, we propose a new self-triggered consensus algorithm in networks of multi-agents. Different from existing works, which are based on the observation of states, here, each agent determines its next update time based on its…

Optimization and Control · Mathematics 2015-01-30 Bo Liu , Wenlian Lu , Licheng Jiao , Tianping Chen

This paper addresses the problem of finding cycles in the state transition graphs of synchronous Boolean networks. Synchronous Boolean networks are a class of deterministic finite state machines which are used for the modeling of gene…

Molecular Networks · Quantitative Biology 2009-01-29 Elena Dubrova , Maxim Teslenko

Dynamic gene-regulatory networks are complex since the number of potential components involved in the system is very large. Estimating dynamic networks is an important task because they compromise valuable information about interactions…

Methodology · Statistics 2012-05-15 Antonino Abbruzzo , Ernst Wit

Many biological systems, such as metabolic pathways, exhibit bistability behavior: these biological systems exhibit two distinct stable states with switching between the two stable states controlled by certain conditions. Since…

Quantitative Methods · Quantitative Biology 2013-07-04 Yi Ming Zou

The aim of this paper is to analyze a class of consensus algorithms with finite-time or fixed-time convergence for dynamic networks formed by agents with first-order dynamics. In particular, in the analyzed class a single evaluation of a…

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