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In this paper, we have studied epidemiological models for Ebola infection using nonlinear ordinary differential equations and optimal control theory. We considered optimal control analysis of SIR and SEIR models for the deadly Ebola…

Dynamical Systems · Mathematics 2019-08-23 E. Okyere , J. D. Ankamah , A. K. Hunkpe , D. Mensah

In this paper, we propose two novel immunization strategies, i.e., combined immunization and duplex immunization, for SIS model in directed scale-free networks, and obtain the epidemic thresholds for them with linear and nonlinear…

Physics and Society · Physics 2018-06-05 Wei Shi , Junbo Jia , Pan Yang , Xinchu Fu

Taking precautions before or during the start of a virus outbreak can heavily reduce the number of infected. The question which individuals should be immunized in order to mitigate the impact of the virus on the rest of population has…

Social and Information Networks · Computer Science 2013-03-06 V. V. Kashirin , L. J. Dijkstra

This paper describes an agent-based model of epidemics dynamics. This model is willingly simplified, as its goal is not to predict the evolution of the epidemics, but to explain the underlying mechanisms in an interactive way. This model…

Multiagent Systems · Computer Science 2024-04-16 Carole Adam , Helene Arduin

Massive vaccination against pandemics such as Coronavirus SARS-CoV-2 presents several complexities. The criteria to assess public health policies are fundamental to distribute vaccines in an effective way in order to avoid as many…

Optimization and Control · Mathematics 2023-12-01 José Luis Sainz-Pardo , José Valero

Herd immunity is shaped not only by the infection capacity of a spreading epidemic or the contact structure of the hosting population, but also by how and under what circumstances individuals acquire immunity. Immunization strategies may…

Physics and Society · Physics 2026-02-20 Sámuel G. Balogh , Gergely Ódor , Márton Karsai

This paper focuses on the feedback global stabilization and observer construction for a sterile insect technique model. The Sterile Insect Technique (SIT) is one of the most ecological methods for controlling insect pests responsible for…

Dynamical Systems · Mathematics 2024-12-13 Kala Agbo Bidi

We examine here the effects of recurrent vaccination and waning immunity on the establishment of an endemic equilibrium in a population. An individual-based model that incorporates memory effects for transmission rate during infection and…

Populations and Evolution · Quantitative Biology 2024-11-22 Félix Foutel-Rodier , Arthur Charpentier , Hélène Guérin

We present a data-driven optimal control approach which integrates the reported partial data with the epidemic dynamics for COVID-19. We use a basic Susceptible-Exposed-Infectious-Recovered (SEIR) model, the model parameters are…

Optimization and Control · Mathematics 2020-12-22 Hailiang Liu , Xuping Tian

This work focuses on optimal controls of a class of stochastic SIS epidemic models under regime switching. By assuming that a decision maker can either influence the infectivity period or isolate infected individuals, our aim is to minimize…

Optimization and Control · Mathematics 2021-01-12 Ky Tran , George Yin

When the body gets infected by a pathogen or receives a vaccine dose, the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery/vaccination the host might become susceptible again.…

Populations and Evolution · Quantitative Biology 2015-01-15 Maria Vittoria Barbarossa , Gergely Röst

Motivated by our intention to use SIR-type epidemiological models in the context of dynamic networks as provided by large-scale highly interacting inhomogeneous human crowds, we investigate in this framework possibilities to reduce the…

Statistical Mechanics · Physics 2021-03-16 Matteo Colangeli , Adrian Muntean

In this paper we study a susceptible infectious recovered (SIR) model with asymptomatic patients, contact tracing and isolation on a configuration network. Using degree based approximation, we derive a system of differential equations for…

Social and Information Networks · Computer Science 2022-12-20 Duan-Shin Lee , Ting-Zhe Liu , Ruhui Zhang , Cheng-Shang Chang

We study the influence of the rate of the attainment of herd immunity (HI), in the absence of an approved vaccine, on the vulnerable population. We essentially ask the question: how hard the evolution towards the desired herd immunity could…

Populations and Evolution · Quantitative Biology 2020-06-01 Sayantan Mondal , Saumyak Mukherjee , Biman Bagchi

Social distancing has been enacted in order to mitigate the spread of COVID-19. Like many authors, we adopt the classic epidemic SIR model, where the infection rate is the control variable. Its differential flatness property yields ele…

Systems and Control · Electrical Eng. & Systems 2022-10-05 Michel Fliess , Cédric Join , Alberto d'Onofrio

There are few adapted SIR models in the literature that combine vaccination and logistic growth. In this article, we study bifurcations of a SIR model where the class of Susceptible individuals grows logistically and has been subject to…

Dynamical Systems · Mathematics 2023-04-26 João P. S. Maurício de Carvalho , Alexandre A. Rodrigues

Until a vaccine or therapy is found against the SARS-CoV-2 coronavirus, reaching herd immunity appears to be the only mid-term option. However, if the number of infected individuals decreases and eventually fades only beyond this threshold,…

Optimization and Control · Mathematics 2020-06-11 Pierre-Alexandre Bliman , Michel Duprez , Yannick Privat , Nicolas Vauchelet

Incorporating vaccination into mathematical models appears deceptively simple: models integrate vaccine-derived protections, such as reduced susceptibility to infection, using parameters informed by empirical estimates of vaccine efficacy…

Populations and Evolution · Quantitative Biology 2026-05-19 Casey E. Middleton , Oliver Eales , James M. McCaw , Freya M. Shearer

We propose a network behavioral-feedback Susceptible-Infected-Recovered (SIR) epidemic model in which the interaction matrix describing the infection rates across subpopulations depends in feedback on the current epidemic state. This model…

Dynamical Systems · Mathematics 2025-07-08 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani

The non-population conserving SIR (SIR-NC) model to describe the spread of infections in a community is proposed and studied. Unlike the standard SIR model, SIR-NC does not assume population conservation. Although similar in form to the…

Optimization and Control · Mathematics 2020-11-06 Vivek S. Borkar , D. Manjunath