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Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the first of a…

Quantitative Methods · Quantitative Biology 2018-08-21 Fabrice Delbary , Sara Garbarino , Valentina Vivaldi

The classical Hospitals/Residents problem (HR) models the assignment of junior doctors to hospitals based on their preferences over one another. In an instance of this problem, a stable matching M is sought which ensures that no blocking…

Data Structures and Algorithms · Computer Science 2013-08-21 Augustine Kwanashie , David F. Manlove

Effective education in radiotherapy plan quality review requires a robust, regularly updated set of examples and the flexibility to demonstrate multiple possible planning approaches and their consequences. However, the current clinic-based…

Radiation therapy is considered to be one of important treatment protocols for cancers. Radiation therapy employs several beams of ionizing radiation to kill cancer tumors, but such irradiation also causes damage to normal tissues.…

Optimization and Control · Mathematics 2016-12-06 Shogo Kishimoto , Makoto Yamashita

The modern workflow for radiation therapy treatment planning involves mathematical optimization to determine optimal treatment machine parameters for each patient case. The optimization problems can be computationally expensive, requiring…

Mathematical Software · Computer Science 2023-05-30 Felix Liu , Måns I. Andersson , Albin Fredriksson , Stefano Markidis

Skin cancer is a common problem in Australia and indeed around the world. Within the domain of e-Health, there appears to be no satisfactory clinical software that follows the flow of a normal skin cancer examination. This paper introduces…

Computers and Society · Computer Science 2018-08-20 Ahmed D. Alharthi , Peter Busch , Stephen Smith

Radiation therapy has remained as one of the main cancer treatment modalities and a highly cost-effective single modality treatment of cancer care. Typical regimens for fractionated external beam radiotherapy comprise a constant dose…

Medical Physics · Physics 2022-04-19 Jose Alvarez , Kathleen M. Storey , Pavitra Kannan , Heyrim Cho

To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-planning algorithms. We designed an algorithm to automate the…

Reinforcement learning algorithms are gaining popularity in fields in which optimal scheduling is important, and oncology is not an exception. The complex and uncertain dynamics of cancer limit the performance of traditional model-based…

Machine Learning · Computer Science 2019-09-04 Jesus Tordesillas , Juncal Arbelaiz

The linear-quadratic (LQ) model to describe the survival of irradiated cells may be the most frequently used biomathematical model in radiotherapy. There has been an intense debate on the mechanistic origin of the LQ model. An interesting…

Medical Physics · Physics 2021-05-31 Sara Neira , Araceli Gago-Arias , Jacobo Guiu-Souto , Juan Pardo-Montero

Hadrontherapy is a novel technique of cancer radiation therapy which employs beams of charged hadrons, protons and carbon ions in particular. Due to their physical and radiobiological properties, they allow one to obtain a more conformal…

Medical Physics · Physics 2015-05-14 Saverio Braccini

The field of Clinical-Computational Nuclear Medicine is rapidly advancing, fueled by AI, tracer kinetic modeling, radiomics, and integrated informatics. These technologies improve imaging quality, automate lesion detection, and enable…

General description of an on-line procedure of calibration for IGRT (Image Guided Radiotherapy) is given. The algorithm allows to improve targeting cancer by estimating its position in space and suggests appropriate correction of the…

Medical Physics · Physics 2019-04-02 R. A. Kycia , Z. Tabor , A. Woszczyna , D. Kabat , M. Tulik , Z. Latała

Current clinical decision-making in oncology relies on averages of large patient populations to both assess tumor status and treatment outcomes. However, cancers exhibit an inherent evolving heterogeneity that requires an individual…

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

Many diseases, including cancer and chronic conditions, require extended treatment periods and long-term strategies. Machine learning and AI research focusing on electronic health records (EHRs) have emerged to address this need. Effective…

We consider a general difference-in-differences model in which the treatment variable of interest may be non-binary and its value may change in each period. It is generally difficult to estimate treatment parameters defined with the…

Econometrics · Economics 2023-05-30 Takahide Yanagi

Modern external beam cancer radiotherapy applies prescribed radiation doses to tumor targets while minimally affecting nearby vulnerable organs-at-risk (OARs). Creating a treatment plan is difficult and time-consuming with no guarantee of…

Medical Physics · Physics 2021-07-07 Lyndon Hibbard

This paper presents an advanced tumor segmentation framework for real-time MRI-guided radiotherapy, designed for the TrackRAD2025 challenge. Our method leverages the XMem model, a memory-augmented architecture, to segment tumors across long…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Pengchao Deng , Shengqi Chen

Stereotactic radiosurgery is an effective technique to treat brain tumors for which several inverse planning methods may be appropriate. We propose an integer programming model to simultaneous sector duration and isocenter optimization…