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A bioinformatics platform is introduced aimed at identifying models of disease-specific pathways, as well as a set of network measures that can quantify changes in terms of global structure or single link disruptions.The approach integrates…

Molecular Networks · Quantitative Biology 2012-01-17 A. Barla , S. Riccadonna , S. Masecchia , M. Squillario , M. Filosi , G. Jurman , C. Furlanello

This article offers a 3-parameter model of testing, with 1) the difference between the ability level of the examinee and item difficulty; 2) the examinee discrimination and 3) the item discrimination as model parameters.

Machine Learning · Computer Science 2007-05-23 Kromer Victor

Multivariate normal mixtures provide a flexible model for high-dimensional data. They are widely used in statistical genetics, statistical finance, and other disciplines. Due to the unboundedness of the likelihood function, classical…

Statistics Theory · Mathematics 2008-05-27 Jiahua Chen , Xianming Tan

Model inadequacy and measurement uncertainty are two of the most confounding aspects of inference and prediction in quantitative sciences. The process of scientific inference (the inverse problem) and prediction (the forward problem)…

Data Analysis, Statistics and Probability · Physics 2017-11-30 Amir Shahmoradi

We propose a parametrization of the lepton mixing matrix in terms of an expansion in powers of the deviations of the reactor, solar and atmospheric mixing angles from their tri-bimaximal values. We show that unitarity triangles and neutrino…

High Energy Physics - Phenomenology · Physics 2008-11-26 S. F. King

In this paper we show how nuisance parameter marginalized posteriors can be inferred directly from simulations in a likelihood-free setting, without having to jointly infer the higher-dimensional interesting and nuisance parameter posterior…

Cosmology and Nongalactic Astrophysics · Physics 2019-07-17 Justin Alsing , Benjamin Wandelt

Linear mixed-effects models are widely used in analyzing clustered or repeated measures data. We propose a quasi-likelihood approach for estimation and inference of the unknown parameters in linear mixed-effects models with high-dimensional…

Methodology · Statistics 2021-03-10 Sai Li , Tony T. Cai , Hongzhe Li

A discussion is presented of the manner in which uncertainties in parton distributions and related quantities are determined. One of the central problems is the criteria used to judge what variation of the parameters describing a set of…

High Energy Physics - Phenomenology · Physics 2008-11-26 R. S. Thorne , H. Boettcher , A. M. Cooper-Sarkar , B. Reisert , V. Shekelyan , W. J. Stirling , D. R. Stump , A. Vogt

In this article, the problem of identifying the source term in transport processes given by a complete parabolic equation is studied mathematically from noisy measurements taken at an arbitrary fixed time. The problem is solved analytically…

Analysis of PDEs · Mathematics 2024-08-12 Guillermo Federico Umbricht , Diana Rubio

A major challenge in sparsity pattern estimation is that small modes are difficult to detect in the presence of noise. This problem is alleviated if one can observe samples from multiple realizations of the nonzero values for the same…

Information Theory · Computer Science 2011-07-29 Galen Reeves , Michael Gastpar

We introduce several methods for assessing sensitivity to unmeasured confounding in marginal structural models; importantly we allow treatments to be discrete or continuous, static or time-varying. We consider three sensitivity models: a…

Methodology · Statistics 2022-10-12 Matteo Bonvini , Edward Kennedy , Valerie Ventura , Larry Wasserman

We study the spectral density of factor models of multivariate time series. By making use of the Random Matrix Theory we analytically quantify the effect of noise dressing on the spectral density due to the finiteness of the sample. We…

Statistical Mechanics · Physics 2007-05-23 Fabrizio Lillo , Rosario N. Mantegna

Important advances have recently been achieved in developing procedures yielding uniformly valid inference for a low dimensional causal parameter when high-dimensional nuisance models must be estimated. In this paper, we review the…

Statistics Theory · Mathematics 2025-09-08 Niloofar Moosavi , Jenny Häggström , Xavier de Luna

Calibration is nowadays one of the most important processes involved in the extraction of valuable data from measurements. The current availability of an optimum data cube measured from a heterogeneous set of instruments and surveys relies…

Instrumentation and Methods for Astrophysics · Physics 2012-08-13 Maria Jose Marquez

This paper discusses a general framework for smoothing parameter estimation for models with regular likelihoods constructed in terms of unknown smooth functions of covariates. Gaussian random effects and parametric terms may also be…

Methodology · Statistics 2016-05-10 Simon N. Wood , Natalya Pya , Benjamin Säfken

We propose a theory of unimodal maps perturbed by an heteroscedastic Markov chain noise and experiencing another heteroscedastic noise due to uncertain observation. We address and treat the filtering problem showing that by collecting more…

Statistics Theory · Mathematics 2024-11-26 Fabrizio Lillo , Stefano Marmi , Matteo Tanzi , Sandro Vaienti

Interpreting data with mathematical models is an important aspect of real-world industrial and applied mathematical modeling. Often we are interested to understand the extent to which a particular set of data informs and constrains model…

Methodology · Statistics 2025-03-06 Matthew J Simpson , Ruth E Baker

Limit distributions of likelihood ratio statistics are well-known to be discontinuous in the presence of nuisance parameters at the boundary of the parameter space, which lead to size distortions when standard critical values are used for…

Econometrics · Economics 2025-07-29 Giuseppe Cavaliere , Adam McCloskey , Rasmus S. Pedersen , Anders Rahbek

In some high-dimensional and semiparametric inference problems involving two populations, the parameter of interest can be characterized by two-sample U-statistics involving some nuisance parameters. In this work we first extend the…

Methodology · Statistics 2024-02-02 Yuchen Chen , Jing Lei

Nonlinear dynamical systems, ranging from insect populations to lasers and chemical reactions, might exhibit sensitivity to small perturbations in their control parameters, resulting in uncertainties on the predictability of tunning…

Chaotic Dynamics · Physics 2014-03-10 E. S. Medeiros , I. L. Caldas , M. S. Baptista
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