Related papers: Neural Dynamics in Parkinsonian Brain:The Boundary…
Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic…
Low-dimensional yet rich dynamics often emerge in the brain. Examples include oscillations and chaotic dynamics during sleep, epilepsy, and voluntary movement. However, a general mechanism for the emergence of low dimensional dynamics…
Cortical activity in-vivo displays relaxational time scales much longer than the membrane time constant of the neurons or the deactivation time of ionotropic synaptic conductances. The mechanisms responsible for such slow dynamics are not…
The cognitive functions of human and non-human primates rely on the dynamic interplay of distributed neural assemblies. As such, it seems unlikely that cognition can be supported by macroscopic brain dynamics at the proximity of…
Synchronization phenomena are pervasive in biology. In neuronal networks, the mechanisms of synchronization have been extensively studied from both physiological and computational viewpoints. The functional role of synchronization has also…
Information processing in the brain is coordinated by the dynamic activity of neurons and neural populations at a range of spatiotemporal scales. These dynamics, captured in the form of electrophysiological recordings and neuroimaging, show…
The dynamics of three mutually coupled cortical neurons with time delays in the coupling are explored numerically and analytically. The neurons are coupled in a line, with the middle neuron sending a somewhat stronger projection to the…
We show that the unavoidable increase in neuronal response latency to ongoing stimulation serves as a nonuniform gradual stretching of neuronal circuit delay loops and emerges as an essential mechanism in the formation of various types of…
Neuronal oscillations are closely related to the symptoms of Parkinson's disease (PD). In this study, we explore how random fluctuations (or "stochastic inputs") affect these oscillations in brain states, which reflect the collective…
The presence of noise in non linear dynamical systems can play a constructive role, increasing the degree of order and coherence or evoking improvements in the performance of the system. An example of this positive influence in a biological…
Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained…
Neural synchrony in the brain at rest is usually variable and intermittent, thus intervals of predominantly synchronized activity are interrupted by intervals of desynchronized activity. Prior studies suggested that this temporal structure…
Dynamical balance of excitation and inhibition is usually invoked to explain the irregular low firing activity observed in the cortex. We propose a robust nonlinear balancing mechanism for a random network of spiking neurons, which works…
In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of…
Synchronization is studied in a spatially-distributed network of weekly-coupled, excitatory neurons of Hodgkin-Huxley type. All neurons are coupled to each other synaptically with a fixed time delay and a coupling strength inversely…
In neurosciences, the brain processes information via the firing patterns of connected neurons operating across a spectrum of frequencies. To better understand the effects of these frequencies in the neuron dynamics, we have simulated a…
Highly correlated brain dynamics produces synchronized states with no behavioral value, while weakly correlated dynamics prevent information flow. In between these states, the unique dynamical features of the critical state endow the brain…
The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to…
The synchronized activity of neuronal populations can lead to pathological over-synchronization in conditions such as epilepsy and Parkinson disease. Such states can be desynchronized by brief electrical pulses. But when the underlying…
Human cognition emerges from coordinated spiking dynamics in distributed neural circuits, where information is encoded via both firing rates and precise spike timing determined by brain rhythms. Inspired by this notion, we propose a…