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A large-scale deep model pre-trained on massive labeled or unlabeled data transfers well to downstream tasks. Linear evaluation freezes parameters in the pre-trained model and trains a linear classifier separately, which is efficient and…

Machine Learning · Computer Science 2023-05-30 Chenyu Zheng , Guoqiang Wu , Fan Bao , Yue Cao , Chongxuan Li , Jun Zhu

Genome sequencing is the basis for many modern biological and medicinal studies. With recent technological advances, metagenomics has become a problem of interest. This problem entails the analysis and reconstruction of multiple DNA…

Probability · Mathematics 2022-01-14 Marlee Herring

We study pattern matching problems on two major representations of uncertain sequences used in molecular biology: weighted sequences (also known as position weight matrices, PWM) and profiles (i.e., scoring matrices). In the simple version,…

Data Structures and Algorithms · Computer Science 2016-07-12 Tomasz Kociumaka , Solon P. Pissis , Jakub Radoszewski

Out-of-distribution generalization capabilities of sequence-to-sequence models can be studied from the lens of two crucial forms of generalization: length generalization -- the ability to generalize to longer sequences than ones seen during…

Machine Learning · Computer Science 2025-05-29 Kartik Ahuja , Amin Mansouri

Motivation: Gene selection has become a common task in most gene expression studies. The objective of such research is often to identify the smallest possible set of genes that can still achieve good predictive performance. The problem of…

This paper studies the sample complexity of searching over multiple populations. We consider a large number of populations, each corresponding to either distribution P0 or P1. The goal of the search problem studied here is to find one…

Information Theory · Computer Science 2016-11-17 Matthew L. Malloy , Gongguo Tang , Robert D. Nowak

We investigate the performance of large language models on repetitive deterministic prediction tasks and study how the sequence accuracy rate scales with output length. Each such task involves repeating the same operation n times. Examples…

Artificial Intelligence · Computer Science 2025-11-25 Wanda Hou , Leon Zhou , Hong-Ye Hu , Yubei Chen , Yi-Zhuang You , Xiao-Liang Qi

Recently, several classifiers that combine primary tumor data, like gene expression data, and secondary data sources, such as protein-protein interaction networks, have been proposed for predicting outcome in breast cancer. In these…

Machine Learning · Computer Science 2013-10-15 C. Staiger , S. Cadot , R. Kooter , M. Dittrich , T. Mueller , G. W. Klau , L. F. A. Wessels

Purpose: This study aimed to enhance protein sequence classification using natural language processing (NLP) techniques while addressing the impact of sequence similarity on model performance. We compared various machine learning and deep…

Quantitative Methods · Quantitative Biology 2025-05-26 Huma Perveen , Julie Weeds

This work quantifies the risk of training data leakage from LLMs (Large Language Models) using sequence-level probabilities. Computing extraction probabilities for individual sequences provides finer-grained information than has been…

Computation and Language · Computer Science 2025-04-17 Trishita Tiwari , G. Edward Suh

In this paper, we address the problem of identifying protein functionality using the information contained in its aminoacid sequence. We propose a method to define sequence similarity relationships that can be used as input for…

Applications · Statistics 2007-11-12 A. G. Flesia , R. Fraiman , F. G. Leonardi

Text classification is one of the most widely studied tasks in natural language processing. Motivated by the principle of compositionality, large multilayer neural network models have been employed for this task in an attempt to effectively…

Computation and Language · Computer Science 2018-08-07 Devendra Singh Sachan , Manzil Zaheer , Ruslan Salakhutdinov

Numbers and numerical vectors account for a large portion of data. However, recently the amount of string data generated has increased dramatically. Consequently, classifying string data is a common problem in many fields. The most widely…

Machine Learning · Statistics 2016-02-24 Hitoshi Koyano , Morihiro Hayashida , Tatsuya Akutsu

Sequence-to-Sequence models were introduced to tackle many real-life problems like machine translation, summarization, image captioning, etc. The standard optimization algorithms are mainly based on example-to-example matching like maximum…

Computation and Language · Computer Science 2018-09-05 Wenhu Chen , Guanlin Li , Shujie Liu , Zhirui Zhang , Mu Li , Ming Zhou

Recursive processing in sentence comprehension is considered a hallmark of human linguistic abilities. However, its underlying neural mechanisms remain largely unknown. We studied whether a modern artificial neural network trained with…

Computation and Language · Computer Science 2021-05-04 Yair Lakretz , Dieuwke Hupkes , Alessandra Vergallito , Marco Marelli , Marco Baroni , Stanislas Dehaene

Identifying computational mechanisms for memorization and retrieval of data is a long-standing problem at the intersection of machine learning and neuroscience. Our main finding is that standard overparameterized deep neural networks…

Machine Learning · Computer Science 2022-05-25 Adityanarayanan Radhakrishnan , Mikhail Belkin , Caroline Uhler

Within psychology, neuroscience and artificial intelligence, there has been increasing interest in the proposal that the brain builds probabilistic models of sensory and linguistic input: that is, to infer a probabilistic model from a…

Machine Learning · Computer Science 2017-08-08 Paul M. B. Vitanyi , Nick Chater

Sequence-to-sequence learning with neural networks has become the de facto standard for sequence prediction tasks. This approach typically models the local distribution over the next word with a powerful neural network that can condition on…

Computation and Language · Computer Science 2021-11-17 Yoon Kim

Classification is an important task in many fields including biomedical research and machine learning. Traditionally, a classification rule is constructed based a bunch of labeled data. Recently, due to technological innovation and…

Methodology · Statistics 2014-06-19 Jing Wang , Eunsik Park , Yuan-chin Ivan Chang

We describe extensive numerical experiments assessing and quantifying how classifier performance depends on the quality of the training data, a frequently neglected component of the analysis of classifiers. More specifically, in the…

Machine Learning · Computer Science 2026-02-26 Alan F. Karr , Regina Ruane
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