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State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…

Recently, imaging by microspheres and dielectric particle-lenses emerged as a simple solution to obtaining super-resolution images of nanoscale devices and structures. Calibrated resolution of ~{\lambda}/6 - {\lambda}/8 has been…

Optics · Physics 2021-08-26 Zengbo Wang , Boris Luk'yanchuk

Optical superresolution microscopy is an important field, where nonlinear optical processes or prior information is used to defeat the classical diffraction limit of light. Quantum correlation microscopy uses photon arrival statistics from…

Optics · Physics 2023-10-13 Jaret J. Vasquez-Lozano , Shuo Li , Andrew D. Greentree

Fluorescence imaging is an essential diagnostic tool in many fields, but diffraction-limited optical imaging at depth is limited by scattering. Here, we present a method based on multiple random illuminations, combined with a computational…

Optics · Physics 2026-03-30 Lei Zhu , Tengfei Wu , Bernhard Rauer , Hilton B. de Aguiar , Sylvain Gigan

Speckle patterns have been widely used in imaging techniques such as ghost imaging, dynamic speckle illumination microscopy, structured illumination microscopy, and photoacoustic fluctuation imaging. Recent advances in the ability to…

Optics · Physics 2021-05-28 Nicholas Bender , Mengyuan Sun , Hasan Yilmaz , Joerg Bewersdorf , Hui Cao

Fluorescence microscopy is indispensable in nanoscience and biological sciences. The versatility of labeling target structures with fluorescent dyes permits to visualize structure and function at a subcellular resolution with a wide field…

Resolving signals with closely spaced frequencies is central to applications in communications, spectroscopy and sensing. Recent results have shown that quantum sensing protocols can exhibit superresolution, the ability to discriminate…

Quantum Physics · Physics 2026-02-13 Joseph T. Iosue , Paraj Titum , Taohan Lin , Clare Lau , Leigh M. Norris

Existing super-resolution methods of optical imaging hold a solid place as an application in natural sciences, but many new developments allow for beating the diffraction limit in a more subtle way. One of the recently explored strategies…

Quantum Physics · Physics 2022-02-08 Mateusz Mazelanik , Adam Leszczyński , Michał Parniak

Far-field super-resolution fluorescence microscopy has been rapidly developed for applications ranging from cell biology to nanomaterials. However, it remains a significant challenge to achieve super-resolution imaging at depth in opaque…

Optics · Physics 2024-05-01 Tengfei Wu , YoonSeok Baek , Fei Xia , Sylvain Gigan , Hilton B. de Aguiar

We investigate the fundamental limit of biological quantum electron microscopy, which is designed to go beyond the shot noise limit. Inelastic scattering is expected to be the main obstacle in this setting, especially for thick specimens of…

Quantum Physics · Physics 2022-09-14 Hiroshi Okamoto

Super-resolution microscopy is rapidly gaining importance as an analytical tool in the life sciences. A compelling feature is the ability to label biological units of interest with fluorescent markers in living cells and to observe them…

Quantum imaging is emerging as a transformative approach for biomedical applications, applying nonclassical properties of light, such as entanglement, squeezing, and quantum correlations, to overcome fundamental limits of conventional…

For more than a century, the diffraction limit has defined the resolution achievable by passive optical imaging systems. Although some resolution improvement can be gained through classical data processing of the image, it is limited by the…

Quantum Physics · Physics 2026-05-12 A. I. Lvovsky , Michael R. Grace , Saikat Guha , Mankei Tsang , Gerardo Adesso , Nicolas Treps

The diffraction of light imposes a fundamental limit on the resolution of light microscopes. This limit can be circumvented by creating and exploiting independent behaviors of the sample at length scales below the diffraction limit. In…

Biological Physics · Physics 2024-06-19 Mohamadreza Fazel , Michael J. Wester

Super-resolution microscopy overcomes the diffraction limit of conventional light microscopy in spatial resolution. By providing novel spatial or spatio-temporal information on biological processes at nanometer resolution with molecular…

Biological Physics · Physics 2021-11-10 Tianjie Yang , Yaoru Luo , Wei Ji , Ge Yang

Visualizing the details of different cellular structures is of great importance to elucidate cellular functions. However, it is challenging to obtain high quality images of different structures directly due to complex cellular environments.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-01 Yi Liu , Hao Yuan , Zhengyang Wang , Shuiwang Ji

To overcome the limit of diffraction while achieving the superresolution technique, solid immersion lenses are the key optical elements for data storage and nanophotonics applications. Recent demonstrations have shown how different…

Optics · Physics 2026-02-24 Subhankar Roy , Jianping Hu , M Ummal Momeen

The contrast of an image can be degraded by the presence of background light and sensor noise. To overcome this degradation, quantum illumination protocols have been theorised (Science 321 (2008), Physics Review Letters 101 (2008)) that…

Quantum Physics · Physics 2021-09-21 Thomas Gregory , Paul-Antoine Moreau , Ermes Toninelli , Miles J. Padgett

We propose a technique to obtain sub-wavelength resolution in quantum imaging with potentially 100% contrast using incoherent light. Our method requires neither path-entangled number states nor multi-photon absorption. The scheme makes use…

Quantum Physics · Physics 2009-11-13 C. Thiel , T. Bastin , J. Martin , E. Solano , J. von Zanthier , G. S. Agarwal

Despite advances in low-light level detection, single-photon methods such as photon correlation have rarely been used in the context of imaging. The few demonstrations, for example of sub-diffraction limited imaging utilizing quantum…

Optics · Physics 2017-03-14 Yonatan Israel , Ron Tenne , Dan Oron , Yaron Silberberg