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This work is devoted to the investigation of the most probable transition time between metastable states for stochastic dynamical systems. Such a system is modeled by a stochastic differential equation with non-vanishing Brownian noise, and…

Mathematical Physics · Physics 2021-08-11 Yuanfei Huang , Ying Chao , Wei Wei , Jinqiao Duan

This paper is concerned with transition paths within the framework of the overdamped Langevin dynamics model of chemical reactions. We aim to give an efficient description of typical transition paths in the small temperature regime. We…

Probability · Mathematics 2017-06-27 Yulong Lu , Andrew M. Stuart , Hendrik Weber

We investigate a quantitative network of gene expression dynamics describing the competence development in Bacillus subtilis. First, we introduce an Onsager-Machlup approach to quantify the most probable transition pathway for both…

Molecular Networks · Quantitative Biology 2022-04-27 Jianyu Hu , Xiaoli Chen , Jinqiao Duan

The time evolution of many physical, chemical, and biological systems can be modelled by stochastic transitions between the minima of the potential energy surface describing the system of interest. We show that in cases where there are two…

Statistical Mechanics · Physics 2024-09-11 S. P. Fitzgerald , A. Bailey Hass , G. Díaz Leines , A. J. Archer

The predictive ability of stochastic chemical reactions is currently limited by the lack of closed form solutions to the governing chemical master equation. To overcome this limitation, this paper proposes a computational method capable of…

Quantitative Methods · Quantitative Biology 2019-01-08 Yuta Sakurai , Yutaka Hori

The most probable transition paths of a stochastic dynamical system are the global minimizers of the Onsager-Machlup action functional and can be described by a necessary but not sufficient condition, the Euler-Lagrange equation (a…

Mathematical Physics · Physics 2023-12-07 Yuanfei Huang , Qiao Huang , Jinqiao Duan

The present manuscript gives a theoretical description of the first-order phase transition in a cell fluid model with a modified Morse potential and additional repulsive interaction. In the framework of the grand canonical ensemble, the…

Statistical Mechanics · Physics 2019-12-03 M. P. Kozlovskii , O. A. Dobush

In this study, we investigate the transition path of a free active Brownian particle (ABP) on a two-dimensional plane between two given states. The extremum conditions for the most probable path connecting the two states are derived using…

Statistical Mechanics · Physics 2024-05-20 Kento Yasuda , Kenta Ishimoto

First-order nonequilibrium phase transitions observed in active matter, fluid dynamics, biology, climate science, and other systems with irreversible dynamics are challenging to analyze because they cannot be inferred from a simple free…

Statistical Mechanics · Physics 2022-06-06 Ruben Zakine , Eric Vanden-Eijnden

This work is devoted to deriving the Onsager-Machlup function for a class of stochastic dynamical systems under (non-Gaussian) Levy noise as well as (Gaussian) Brownian noise, and examining the corresponding most probable paths. This…

Mathematical Physics · Physics 2020-01-08 Ying Chao , Jinqiao Duan

This paper investigates bifurcation phenomena and stability of most probable transition paths (MPTPs) in stochastic dynamical systems through a combined variational and spectral flow approach. Within the Onsager-Machlup framework, MPTPs are…

Dynamical Systems · Mathematics 2025-08-13 Jinqiao Duan , Zhihao Zhao

Given two metastable states A and B of a biomolecular system, the problem is to calculate the likely paths of the transition from A to B. Such a calculation is more informative and more manageable if done for a reduced set of collective…

Computational Physics · Physics 2010-11-13 Ruijun Zhao , Juanfang Shen , Robert D. Skeel

The Onsager--Machlup action functional is an important concept in statistical mechanics and thermodynamics to describe the probability of fluctuations in nonequilibrium systems. It provides a powerful tool for analyzing and predicting the…

Probability · Mathematics 2024-12-03 Yuanfei Huang , Xiang Zhou , Jinqiao Duan

We consider diffusion-like paths that are explored by a particle moving via a conservative force while being in thermal equilibrium with its surroundings. To probe rare transitions, we use the Onsager-Machlup (OM) functional as a path…

Statistical Mechanics · Physics 2016-01-01 Patrick Malsom , Frank Pinski

Many natural systems exhibit tipping points where changing environmental conditions spark a sudden shift to a new and sometimes quite different state. Global climate change is often associated with the stability of marine carbon stocks. We…

Dynamical Systems · Mathematics 2024-06-19 Jianyu Chen , Jianyu Hu , Wei Wei , Jinqiao Duan

We study a micro and macroscopic model for chemical reactions with feedback between reactions and temperature of the solute. The first result concerns the quasipotential as the large-deviation rate of the microscopic invariant measure. The…

Mathematical Physics · Physics 2021-11-25 D. R. Michiel Renger

A phase transition of gas-liquid type with an upper critical point is examined which arises in a model of charges of one sign on compensating background (OCP). The phase transition parameters are dependent on the detailed assumptions about…

Plasma Physics · Physics 2009-01-23 Igor Iosilevskiy

This paper establishes an indirect approximation theorem for the most probable transition pathway of a stochastic interacting particle system in the mean-field framework. This paper studied the problem of indirect approximation of the most…

Dynamical Systems · Mathematics 2026-05-27 Jianyu Chen , Ting Gao , Galina Strelkova , Jinqiao Duan

The emergence of transition phenomena between metastable states induced by noise plays a fundamental role in a broad range of nonlinear systems. The computation of the most probable paths is a key issue to understand the mechanism of…

Dynamical Systems · Mathematics 2021-01-27 Yang Li , Jinqiao Duan , Xianbin Liu

A path information is defined in connection with the different possible paths of chaotic system moving in its phase space between two cells. On the basis of the assumption that the paths are differentiated by their actions, we show that the…

Statistical Mechanics · Physics 2015-06-24 Qiuping A. Wang
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