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Regulatory networks (RNs) are a well-accepted modelling formalism in computational systems biology. The control of RNs is currently receiving a lot of attention because it provides a computational basis for cell reprogramming -- an…

Systems and Control · Electrical Eng. & Systems 2022-03-01 Luboš Brim , Samuel Pastva , David Šafránek , Eva Šmijáková

Boolean networks are discrete dynamical systems for modeling regulation and signaling in living cells. We investigate a particular class of Boolean functions with inhibiting inputs exerting a veto (forced zero) on the output. We give…

Molecular Networks · Quantitative Biology 2014-09-05 Haleh Ebadi , Konstantin Klemm

A novel method for estimating Bayesian network (BN) parameters from data is presented which provides improved performance on test data. Previous research has shown the value of representing conditional probability distributions (CPDs) via…

Machine Learning · Computer Science 2013-01-14 Geoff A. Jarrad

The network inference problem arises in biological research when one needs to quantitatively choose the best protein-interaction model for explaining a phenotype. The diverse nature of the data and nonlinear dynamics pose significant…

Molecular Networks · Quantitative Biology 2025-12-22 Guy Karlebach

Bayesian networks (BN) are directed acyclic graphical (DAG) models that have been adopted into many fields for their strengths in transparency, interpretability, probabilistic reasoning, and causal modeling. Given a set of data, one hurdle…

Artificial Intelligence · Computer Science 2023-05-19 Christian D. Blakely

A Boolean network (BN) with $n$ components is a discrete dynamical system described by the successive iterations of a function $f:\{0,1\}^n \to \{0,1\}^n$. This model finds applications in biology, where fixed points play a central role.…

Combinatorics · Mathematics 2022-02-10 Florian Bridoux , Amélia Durbec , Kévin Perrot , Adrien Richard

Traditional models of wormlike chains in shear flows at finite temperature approximate the equation of motion via finite difference discretization (bead and rod models). We introduce here a new method based on a spectral representation in…

Soft Condensed Matter · Physics 2007-05-23 Chris H. Wiggins , Alberto Montesi , Matteo Pasquali

We evaluate the probability that a Boolean network returns to an attractor after perturbing h nodes. We find that the return probability as function of h can display a variety of different behaviours, which yields insights into the…

Statistical Mechanics · Physics 2010-07-02 C. Fretter , B. Drossel

A conjunctive Boolean network (CBN) is a finite state dynamical system, whose variables take values from a binary set, and the value update rule for each variable is a Boolean function consisting only of logic AND operations. We investigate…

Dynamical Systems · Mathematics 2019-07-11 Xudong Chen , Zuguang Gao , Tamer Başar

We study the equilibrium properties of an Ising model on a disordered random network where the disorder can be quenched or annealed. The network consists of four-fold coordinated sites connected via variable length one-dimensional chains.…

Statistical Mechanics · Physics 2015-06-22 Abdul N. Malmi-Kakkada , Oriol T. Valls , Chandan Dasgupta

In this paper, we propose a generalization of the Batch Normalization (BN) algorithm, diminishing batch normalization (DBN), where we update the BN parameters in a diminishing moving average way. BN is very effective in accelerating the…

Machine Learning · Computer Science 2019-02-20 Yintai Ma , Diego Klabjan

A Boolean network is a discrete dynamical system operating on vectors of Boolean variables. The action of a Boolean network can be conveniently expressed as a system of Boolean update functions, computing the new values for each component…

Formal Languages and Automata Theory · Computer Science 2023-03-02 Artiom Alhazov , Vincent Ferrari-Dominguez , Rudolf Freund , Nicolas Glade , Sergiu Ivanov

We report a detailed computational study by Brownian Dynamics simulations of the structure and dynamics of a liquid of patchy particles which develops an amorphous tetrahedral network upon decreasing temperature. The highly directional…

Soft Condensed Matter · Physics 2016-12-02 Sandalo Roldan-Vargas , Lorenzo Rovigatti , Francesco Sciortino

Boolean network models have gained popularity in computational systems biology over the last dozen years. Many of these networks use canalizing Boolean functions, which has led to increased interest in the study of these functions. The…

Discrete Mathematics · Computer Science 2015-04-29 Qijun He , Matthew Macauley

Understanding the characteristics of neural networks is important but difficult due to their complex structures and behaviors. Some previous work proposes to transform neural networks into equivalent Boolean expressions and apply…

Machine Learning · Computer Science 2023-06-09 Yiping Tang , Kohei Hatano , Eiji Takimoto

Threshold networks are used as models for neural or gene regulatory networks. They show a rich dynamical behaviour with a transition between a frozen and a chaotic phase. We investigate the phase diagram of randomly connected threshold…

Statistical Mechanics · Physics 2009-11-13 Agnes Szejka , Tamara Mihaljev , Barbara Drossel

This paper describes and discusses Bayesian Neural Network (BNN). The paper showcases a few different applications of them for classification and regression problems. BNNs are comprised of a Probabilistic Model and a Neural Network. The…

Machine Learning · Computer Science 2018-01-31 Vikram Mullachery , Aniruddh Khera , Amir Husain

Transport phenomena in spatially periodic systems far from thermal equilibrium are considered. The main emphasize is put on directed transport in so-called Brownian motors (ratchets), i.e. a dissipative dynamics in the presence of thermal…

Statistical Mechanics · Physics 2009-10-31 Peter Reimann

Despite the large quantity of information available, thorough researches in various biological databases are still needed in order to reconstruct and understand the steps that lead to known or new phenomena. By using protein-protein…

Molecular Networks · Quantitative Biology 2014-12-03 Alberto Calderone

The study of the interplay between the structure and dynamics of complex multilevel systems is a pressing challenge nowadays. In this paper, we use a semi-annealed approximation to study the stability properties of Random Boolean Networks…

Physics and Society · Physics 2012-10-31 Emanuele Cozzo , Alex Arenas , Yamir Moreno