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In this work we have investigated the evolutionary dynamics of a generalist pathogen, e.g. a virus population, that evolves towards specialisation in an environment with multiple host types. We have particularly explored under which…

Dynamical Systems · Mathematics 2020-06-24 Anel Nurtay , Matthew G. Hennessy , Lluís Alsedà , Santiago F. Elena , Josep Sardanyés

Multipartite viruses replicate through a puzzling evolutionary strategy. Their genome is segmented into two or more parts, and encapsidated in separate particles that appear to propagate independently. Completing the replication cycle,…

Physics and Society · Physics 2019-03-26 Eugenio Valdano , Susanna Manrubia , Sergio Gómez , Alex Arenas

The evolution of various competing cell types in tissues, and the resulting persistent tissue population, is studied numerically and analytically in a particle-based model of active tissues. Mutations change the properties of cells in…

Populations and Evolution · Quantitative Biology 2024-06-03 Tobias Büscher , Nirmalendu Ganai , Gerhard Gompper , Jens Elgeti

Clonal interference, competition between multiple co-occurring beneficial mutations, has a major role in adaptation of asexual populations. We provide a simple individual based stochastic model of clonal interference taking into account a…

Probability · Mathematics 2015-05-19 Sylvain Billiard , Charline Smadi

The outcome of competition among species is influenced by the spatial distribution of species and effects such as demographic stochasticity, immigration fluxes, and the existence of preferred habitats. We introduce an individual-based model…

Populations and Evolution · Quantitative Biology 2010-07-19 Simone Pigolotti , Massimo Cencini

The design of protocols to suppress the propagation of viral infections is an enduring enterprise, especially hindered by limited knowledge of the mechanisms through which extinction of infection propagation comes about. We here report on a…

Populations and Evolution · Quantitative Biology 2015-02-18 Jose A. Cuesta , Jacobo Aguirre , Jose A. Capitan , Susanna C. Manrubia

Laboratory experiments with bacterial colonies, under well-controlled conditions often lead to evolutionary diversification, where at least two ecotypes emerge from an initially monomorphic population. Empirical evidence suggests that such…

Populations and Evolution · Quantitative Biology 2024-11-06 Roberto Corral López , Samir Suweis , Sandro Azaele , Miguel A. Muñoz

In this paper we propose a Moran model that describes the population dynamics of two types: While the first type has a selective advantage during reproduction, the second type can avoid replacement during reproduction with some positive…

Populations and Evolution · Quantitative Biology 2026-03-02 Jochen Blath , Baptiste Le Duigou , András Tóbiás

Given an endogenous timescale set by invasion in a constant environment, we introduced periodic temporal variation in competitive superiority by alternating the species' propagation rates. By manipulating habitat size and introduction rate,…

Populations and Evolution · Quantitative Biology 2011-05-10 Lauren O'Malley , G. Korniss , Sai Satya Praveen Mungara , Thomas Caraco

We perform individual-based Monte Carlo simulations in a community consisting of two predator species competing for a single prey species, with the purpose of studying biodiversity stabilization in this simple model system. Predators are…

Populations and Evolution · Quantitative Biology 2018-07-11 Sheng Chen , Ulrich Dobramysl , Uwe C. Täuber

Here we study the effects of adopting different strategies against different opponent instead of adopting the same strategy against all of them in the prisoner dilemma structured in well-mixed populations. We consider an evolutionary…

Physics and Society · Physics 2015-05-14 Lucas Wardil , Jafferson K. L. da Silva

Prion and prion-like molecules are a type of self replicating aggregate protein that have been implicated in a variety of neurodegenerative diseases. Over recent decades the molecular dynamics of prions have been characterized both…

Populations and Evolution · Quantitative Biology 2022-07-06 Saul Acevedo , Alexander J. Stewart

We propose a physical theory underlying the temporal evolution of competing virus variants that relies on the existence of (quasi) fixed points capturing the large time scale invariance of the dynamics. To motivate our result we first…

Populations and Evolution · Quantitative Biology 2022-03-23 Giacomo Cacciapaglia , Corentin Cot , Adele de Hoffer , Stefan Hohenegger , Francesco Sannino , Shahram Vatani

Biological and social systems are structured at multiple scales, and the incentives of individuals who interact in a group may diverge from the collective incentive of the group as a whole. Mechanisms to resolve this tension are responsible…

Populations and Evolution · Quantitative Biology 2023-05-31 Daniel B. Cooney , Simon A. Levin , Yoichiro Mori , Joshua B. Plotkin

Environment plays a fundamental role in the competition for resources, and hence in the evolution of populations. Here, we study a well-mixed, finite population consisting of two strains competing for the limited resources provided by an…

Populations and Evolution · Quantitative Biology 2017-10-16 Karl Wienand , Erwin Frey , Mauro Mobilia

We are interested in modeling some two-level population dynamics, resulting from the interplay of ecological interactions and phenotypic variation of individuals (or hosts) and the evolution of cells (or parasites) of two types living in…

Probability · Mathematics 2011-01-21 Sylvie Méléard , Sylvie Roelly

Character evolution that affects ecological community interactions often occurs contemporaneously with temporal changes in population size, potentially altering the very nature of those dynamics. Such eco-evolutionary processes may be most…

Populations and Evolution · Quantitative Biology 2012-06-12 Laura E. Jones , Lutz Becks , Stephen P. Ellner , Nelson G. Hairston , Takehito Yoshida , Gregor F. Fussmann

Microbial communities harbor extensive fine-scale diversity: closely-related strains of the same species coexist alongside many distantly-related taxa. Yet strain coexistence remains poorly understood, largely because most studies neglect…

Populations and Evolution · Quantitative Biology 2026-03-17 Naven Narayanan Venkatanarayanan , Akshit Goyal

We use a multitype continuous time Markov branching process model to describe the dynamics of the spread of parasites of two types that can mutate into each other in a common host population. Instead of using a single virulence…

Probability · Mathematics 2011-09-02 Konstantin Borovkov , Robert Day , Timothy Rice

Competition between individuals drives the evolution of whole species. Although the fittest individuals survive the longest and produce the most offspring, in some circumstances the resulting species may not be optimally fit. Here, using…

Populations and Evolution · Quantitative Biology 2015-09-24 Tim Rogers , Alan J. McKane