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We apply an information theoretic treatment of action potential time series measured with microelectrode arrays to estimate the connectivity of mammalian neuronal cell assemblies grown {\it in vitro}. We infer connectivity between two…

Neurons and Cognition · Quantitative Biology 2007-05-23 Luis M. A. Bettencourt , Greg J. Stephens , Michael I. Ham , Guenter W. Gross

Understanding individual cortical development is essential for identifying deviations linked to neurodevelopmental disorders. However, current normative modelling frameworks struggle to capture fine-scale anatomical details due to their…

Quantitative Methods · Quantitative Biology 2025-08-14 Nashira Baena , Mariana da Silva , Irina Grigorescu , Aakash Saboo , Saga Masui , Jaques-Donald Tournier , Emma C. Robinson

In the study of biological networks, one of the major challenges is to understand the relationships between network structure and dynamics. In this paper, we model in vitro cortical neuronal cultures as stochastic dynamical systems and…

Neurons and Cognition · Quantitative Biology 2022-05-04 Chumin Sun , K. C. Lin , C. Y. Yeung , Emily S. C. Ching , Yu-Ting Huang , Pik-Yin Lai , C. K. Chan

The spiking activity of principal cells in mammalian hippocampus encodes an internalized neuronal representation of the ambient space---a cognitive map. Once learned, such a map enables the animal to navigate a given environment for a long…

Neurons and Cognition · Quantitative Biology 2017-10-10 Andrey Babichev , Dmitriy Morozov , Yuri Dabaghian

Cell movement in the early phase of C. elegans development is regulated by a highly complex process in which a set of rules and connections are formulated at distinct scales. Previous efforts have shown that agent-based, multi-scale…

Quantitative Methods · Quantitative Biology 2018-05-11 Zi Wang , Dali Wang , Chengcheng Li , Yichi Xu , Husheng Li , Zhirong Bao

Gastrulation, namely cell internalization, is a significant milestone during the development of metazoans from worm to human, which generates multiple embryonic layers with distinct cell fates and spatial organizations. Although many…

Cell Behavior · Quantitative Biology 2022-01-17 Jiao Miao , Guoye Guan , Chao Tang

Understanding the nature of the changes exhibited by evolving neuronal dynamics from high-dimensional activity data is essential for advancing neuroscience, particularly in the study of neuronal network development and the pathophysiology…

Neurons and Cognition · Quantitative Biology 2025-03-03 Ho Fai Po , Akke Mats Houben , Anna-Christina Haeb , Yordan P. Raykov , Daniel Tornero , Jordi Soriano , David Saad

During development, the mammalian brain differentiates into specialized regions with distinct functional abilities. While many factors contribute to functional specialization, we explore the effect of neuronal density on the development of…

Neurons and Cognition · Quantitative Biology 2010-04-14 Michael I. Ham , Vadas Gintautas , Marko A. Rodriguez , Ryan A. Bennett , Cara L. Santa Maria , Luis M. A. Bettencourt

Evolution and its intelligence element present thrill and challenges in its exploration. Yet, how species have memory, retrieve them and maintain continuity are the fundamental questions. Most of the phenomenon can only be hypothesised by…

Neurons and Cognition · Quantitative Biology 2024-07-09 Anil Kumar Sharma , Asha Sharma

In this paper we study the spontaneous development of symmetries in the early layers of a Convolutional Neural Network (CNN) during learning on natural images. Our architecture is built in such a way to mimic the early stages of biological…

Neurons and Cognition · Quantitative Biology 2021-04-20 Federico Bertoni , Noemi Montobbio , Alessandro Sarti , Giovanna Citti

Synchronization plays a key role in information processing in neuronal networks. Response of specific groups of neurons are triggered by external stimuli, such as visual, tactile or olfactory inputs. Neurons, however, can be divided into…

Adaptation and Self-Organizing Systems · Physics 2020-03-02 Carolina A. Moreira , Marcus A. M. de Aguiar

Animal locomotion is often subject to constraints arising from anatomical/physiological asymmetries. We use the nematode C.~elegans as a minimal model system to ask whether such constraints might shape locomotion patterns optimized during…

Neurons and Cognition · Quantitative Biology 2024-01-17 W. Mathijs Rozemuller , Steffen Werner , Antonio Carlos Costa , Liam O'Shaughnessy , Greg J. Stephens , Thomas S. Shimizu

This paper describes how realistic neuromorphic networks can have their connectivity fully characterized in analytical fashion. By assuming that all neurons have the same shape and are regularly distributed along the two-dimensional…

Disordered Systems and Neural Networks · Physics 2007-05-23 Luciano da Fontoura Costa , Marconi Soares Barbosa

Traditional approaches to classify the political bias of news articles have failed to generate accurate, generalizable results. Existing networks premised on CNNs and DNNs lack a model to identify and extrapolate subtle indicators of bias…

Neural and Evolutionary Computing · Computer Science 2022-07-27 Agastya Sridharan , Natarajan S

Building on evidence of structural parallels between brain networks and the cosmic web [1], we apply AI-based geometric analysis to cultured neuronal networks. Isolated neurons self-organize into dendritic lattices shaped by reproducible…

Neurons and Cognition · Quantitative Biology 2025-10-14 Wolfgang Kurz , Danny Baranes

Characterizing time-evolving networks is a challenging task, but it is crucial for understanding the dynamic behavior of complex systems such as the brain. For instance, how spatial networks of functional connectivity in the brain evolve…

Applications · Statistics 2021-01-27 Marie Roald , Suchita Bhinge , Chunying Jia , Vince Calhoun , Tülay Adalı , Evrim Acar

Spatial networks, in which nodes and edges are embedded in space, play a vital role in the study of complex systems. For example, many social networks attach geo-location information to each user, allowing the study of not only topological…

Social and Information Networks · Computer Science 2014-03-05 Nicholas D. Larusso , Brian E. Ruttenberg , Ambuj Singh

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

Finding an optimal correspondence between point sets is a common task in computer vision. Existing techniques assume relatively simple relationships among points and do not guarantee an optimal match. We introduce an algorithm capable of…

Computer Vision and Pattern Recognition · Computer Science 2023-01-11 Andrew Lauziere , Ryan Christensen , Hari Shroff , Radu Balan

Many neural systems display cascading behavior characterized by uninterrupted sequences of neuronal firing. This gap precludes an understanding of how variations in network structure manifest in neural dynamics and either support or impinge…

Neurons and Cognition · Quantitative Biology 2019-11-12 Harang Ju , Jason Z. Kim , Danielle S. Bassett