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The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

This report discusses the application of neural networks (NNs) as small segments of the brain. The networks representing the biological connectome are altered both spatially and temporally. The degradation techniques applied here are…

Neurons and Cognition · Quantitative Biology 2020-08-04 Jacob Adamczyk

I address here the question of the mutual interplay of strong correlations and disorder in the system. I consider random version of the Hubbard model. Diagonal randomness is introduced {\it via} random on-site energies and treated by the…

Disordered Systems and Neural Networks · Physics 2007-05-23 Karol I. Wysokinski

Alzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying…

Neurons and Cognition · Quantitative Biology 2025-04-09 Irina Kareva

Inpainting has recently emerged as a valuable and interesting technology to employ in the analysis of medical imaging data, in particular brain MRI. A wide variety of methodologies for inpainting MRI have been proposed and demonstrated on…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Sergey Kuznetsov , Sanduni Pinnawala , Peter A. Wijeratne , Ivor J. A. Simpson

Handwriting is significantly affected by neurological disorders (ND) such as Parkinson's disease (PD) and Alzheimer's disease (AD). Prior works have analyzed handwriting tasks using feature-based approaches or computer-vision techniques,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Gabrielle Chavez , Laureano Moro-Velazquez , Ankur Butala , Najim Dehak , Thomas Thebaud

As the global burden of Alzheimer's disease (AD) continues to grow, early and accurate detection has become increasingly critical, especially in regions with limited access to advanced diagnostic tools. We propose BRAINS (Biomedical…

Machine Learning · Computer Science 2025-11-05 Rajan Das Gupta , Md Kishor Morol , Nafiz Fahad , Md Tanzib Hosain , Sumaya Binte Zilani Choya , Md Jakir Hossen

In recent years many methods have been developed to understand the internal workings of neural networks, often by describing the function of individual neurons in the model. However, these methods typically only focus on explaining the very…

Machine Learning · Computer Science 2024-05-14 Tuomas Oikarinen , Tsui-Wei Weng

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system, characterized by the appearance of focal lesions in the white and gray matter that topographically correlate with an individual…

Computer Vision and Pattern Recognition · Computer Science 2022-01-31 Yang Ma , Chaoyi Zhang , Mariano Cabezas , Yang Song , Zihao Tang , Dongnan Liu , Weidong Cai , Michael Barnett , Chenyu Wang

Spin-memory loss (SML) of electrons traversing ferromagnetic-metal/heavy-metal (FM/HM), FM/normal-metal (FM/NM) and HM/NM interfaces is a fundamental phenomenon that must be invoked to explain consistently large number of spintronic…

Mesoscale and Nanoscale Physics · Physics 2017-12-20 Kapildeb Dolui , Branislav K. Nikolic

A number of life threatening neuro-degenerative disorders had degraded the quality of life for the older generation in particular. Dementia is one such symptom which may lead to a severe condition called Alzheimer's disease if not detected…

Neural and Evolutionary Computing · Computer Science 2024-02-01 Anuvab Sen , Udayon Sen , Subhabrata Roy

Understanding treatment effect heterogeneity is vital to many scientific fields because the same treatment may affect different individuals differently. Quantile regression provides a natural framework for modeling such heterogeneity. We…

Methodology · Statistics 2023-07-12 Alexander Giessing , Jingshen Wang

People with Multiple Sclerosis (MS) complain of problems with hand dexterity and cognitive fatigue. However, in many cases, impairments are subtle and difficult to detect. Functional near-infrared spectroscopy (fNIRS) is a non-invasive…

Machine Learning · Computer Science 2025-09-29 Sadman Saumik Islam , Bruna Dalcin Baldasso , Davide Cattaneo , Xianta Jiang , Michelle Ploughman

Clinical neuroimaging data is naturally hierarchical. Different magnetic resonance imaging (MRI) sequences within a series, different slices covering the head, and different regions within each slice all confer different information. In…

Image and Video Processing · Electrical Eng. & Systems 2024-01-18 David A. Wood

Many neurological diseases are characterized by gradual deterioration of brain structure and function. Large longitudinal MRI datasets have revealed such deterioration, in part, by applying machine and deep learning to predict diagnosis. A…

Image and Video Processing · Electrical Eng. & Systems 2021-05-27 Jiahong Ouyang , Qingyu Zhao , Edith V Sullivan , Adolf Pfefferbaum , Susan F. Tapert , Ehsan Adeli , Kilian M Pohl

Alzheimer's disease is the most common cause of dementia, yet difficult to accurately diagnose without the use of invasive techniques, particularly at the beginning of the disease. This work addresses the classification and analysis of…

Computer Vision and Pattern Recognition · Computer Science 2017-12-06 Wellington Pinheiro dos Santos , Ricardo Emmanuel de Souza , Ascendino Flávio Dias e Silva , Plínio Batista dos Santos Filho

Functional connections in the brain are frequently represented by weighted networks, with nodes representing locations in the brain, and edges representing the strength of connectivity between these locations. One challenge in analyzing…

Applications · Statistics 2022-09-28 Yura Kim , Daniel Kessler , Elizaveta Levina

When transmitting polarised light through histological brain sections, different types of diattenuation (polarisation-dependent attenuation of light) can be observed: In some brain regions, the light is minimally attenuated when it is…

Medical Physics · Physics 2019-02-22 Miriam Menzel , Markus Axer , Katrin Amunts , Hans De Raedt , Kristel Michielsen

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative

Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process involving inflammation, tissue damage, and tissue repair, all…