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We study by simulation the effect of the diffusive motion of repressor molecules on the noise in mRNA and protein levels in the case of a repressed gene. We find that spatial fluctuations due to diffusion can drastically enhance the noise…

Molecular Networks · Quantitative Biology 2007-05-23 Jeroen S. van Zon , Marco J. Morelli , Sorin Tanase-Nicola , Pieter Rein ten Wolde

The occurrence of phase fluctuations due to thermal excitations in Bose-Einstein condensates (BECs) is studied for a variety of temperatures and trap geometries. We observe the statistical nature of the appearence of phase fluctuations and…

Although mechanical properties of DNA are well characterized at the kilo base-pair range, a number of recent experiments have suggested that DNA is more flexible at shorter length scales, which correspond to the regime that is crucial for…

Biomolecules · Quantitative Biology 2015-06-11 Agnes Noy , Ramin Golestanian

A theory for thermomechanical behavior of homogeneous DNA at thermal equilibrium predicts critical temperatures for denaturation under torque and stretch, phase diagrams for stable B--DNA, supercoiling, optimally stable torque, and the…

Soft Condensed Matter · Physics 2015-05-27 Cristiano Nisoli , A. R. Bishop

Direct numerical simulations (DNS) of turbulent channel flows up to $Re_{\tau} \approx 1000$ are conducted to investigate the three-dimensional (consisting of streamwise wavenumber, spanwise wavenumber and frequency) spectrum of wall…

Fluid Dynamics · Physics 2022-03-14 Bowen Yang , Zixuan Yang

We propose a model for the fluctuation dynamics of the local denaturation zones (bubbles) in double-stranded DNA. In our formulation, the DNA strand is model as a one dimensional Rouse chain confined at both the ends. The bubble is formed…

Soft Condensed Matter · Physics 2014-06-25 Rajarshi Chakrabarti

Protein folding is a universal process, very fast and accurate, which works consistently (as it should be) in a wide range of physiological conditions. The present work is based on three premises, namely: ($i$) folding reaction is a process…

Biological Physics · Physics 2015-05-20 J. P. Dal Molin , M. A. A. da Silva , A. Caliri

The spatial organization of DNA involves DNA loop extrusion and the formation of protein-DNA condensates. While the significance of each process is increasingly recognized, their interplay remains unexplored. Using molecular dynamics…

Biological Physics · Physics 2025-01-31 Ryota Takaki , Yahor Savich , Jan Brugués , Frank Jülicher

The thermodynamical properties of heterogeneous DNA sequences are computed by path integral techniques applied to a nonlinear model Hamiltonian. The base pairs relative displacements are interpreted as time dependent paths whose amplitudes…

Statistical Mechanics · Physics 2010-05-12 Marco Zoli

We report quantitative experimental results for the intensity of noise-induced fluctuations below the critical temperature difference $\Delta T_c$ for Rayleigh-B\'enard convection. The structure factor of the fluctuating convection rolls is…

patt-sol · Physics 2009-10-28 Mingming Wu , Guenter Ahlers , David S. Cannell

Bacteria meticulously regulate their intracellular ion concentrations and create ionic concentration gradients across the bacterial membrane. These ionic concentration gradients provide free energy for many cellular processes and are…

Applied Physics · Physics 2022-07-05 Yichao Yang , Hagen Gress , Kamil L. Ekinci

We probe non-equilibrium properties of an active bacterial bath through measurements of correlations of passive tracer particles and the response function of a driven, optically trapped tracer. These measurements demonstrate violation of…

Soft Condensed Matter · Physics 2009-11-13 D. T. N. Chen , A. W. C. Lau , L. A. Hough , M. F. Islam , M. Goulian , T. C. Lubensky , A. G. Yodh

We explore how thermal fluctuations affect the mechanics of thin amorphous spherical shells. In flat membranes with a shear modulus, thermal fluctuations increase the bending rigidity and reduce the in-plane elastic moduli in a…

Soft Condensed Matter · Physics 2017-01-18 Andrej Kosmrlj , David R. Nelson

We study the fluctuational dynamics of a tagged base-pair in double stranded DNA. We calculate the drift force which acts on the tagged base-pair using a potential model that describes interactions at base pairs level and use it to…

Soft Condensed Matter · Physics 2011-06-28 Shikha Srivastava , Yashwant Singh

Hydrated proteins undergo a transition in the deeply supercooled regime, which is attributed to rapid changes in hydration water and protein structural dynamics. Here, we investigate the nanoscale stress relaxation in hydrated lysozyme…

An important question in the physics of superconducting nanostructures is the role of thermal fluctuations on superconductivity in the zero-dimensional limit. Here, we probe the evolution of superconductivity as a function of temperature…

Mesoscale and Nanoscale Physics · Physics 2011-09-13 Ivan Brihuega , Antonio M. Garcia-Garcia , Pedro Ribeiro , Miguel M. Ugeda , Christian H. Michaelis , Sangita Bose , Klaus Kern

We study the dynamics of a single trapped probe surrounded by self-propelled active particles in two dimensions. In the limit of large size separation, we perform an adiabatic elimination of the small active particles to obtain an effective…

Soft Condensed Matter · Physics 2023-07-21 Ashreya Jayaram , Thomas Speck

A system of a solvated canonical B-DNA of 12 base pairs with the specified sequence is initially equilibrated in a state of zero external force $f$ acting on it. After equilibration, a switching experiment is performed over the system by…

Soft Condensed Matter · Physics 2025-08-12 S. Siva Nasarayya Chari , Prabal K. Maiti

The paper deals with the two-state (opening-closing of base pairs) model used to describe the fluctuation dynamics of a single bubble formation. We present an exact solution for the discrete and finite size version of the model that…

Soft Condensed Matter · Physics 2009-11-10 D. J. Bicout , E. Kats

Enhanced dynamical fluctuations of RNAs, facilitated by a network of water molecules with strong interactions with RNA, are suspected to be critical in their ability to respond to a variety of cellular signals. Using atomically detailed…

Biomolecules · Quantitative Biology 2015-01-15 Jeseong Yoon , Jong-Chin Lin , Changbong Hyeon , D. Thirumalai
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